Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Mantica, Federica; Iñiguez, Luis P.; Marquez, Yamile; Permanyer, Jon; Torres Méndez, Antonio; Cruz, Josefa; Franch-Marro, Xavier; Burguera, Demián; Martin, David; Irimia Martínez, Manuel (Nature Research, 2024)
    Regulation of gene expression is arguably the main mechanism underlying the phenotypic diversity of tissues within and between species. Here we assembled an extensive transcriptomic dataset covering 8 tissues across 20 ...
  • Ciampi, Ludovica; Serrano Pubull, Luis, 1982-; Irimia Martínez, Manuel (Wiley, 2024)
    Alternative Splicing (AS) programs serve as instructive signals of cell type specificity, particularly within the brain, which comprises dozens of molecularly and functionally distinct cell types. Among them, retinal ...
  • Sarkar, Soumyadeep; Ramos-Rodríguez, Mireia; Juan-Mateu, Jonàs; Pasquali, Lorenzo; Nakayasu, Ernesto S. (BioMed Central, 2024)
    Background: Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream ...
  • Theissinger, Kathrin; European Reference Genome Atlas Consortium (Elsevier, 2023)
    The availability of public genomic resources can greatly assist biodiversity assessment, conservation, and restoration efforts by providing evidence for scientifically informed management decisions. Here we survey the main ...
  • Moon, Katherine L.; Huson, Heather J.; Morrill, Kathleen; Wang, Ming-Shan; Li, Xue; Srikanth, Krishnamoorthy; Zoonomia Consortium; Lindblad-Toh, Kerstin; Svenson, Gavin J.; Karlsson, Elinor K.; Shapiro, Beth (American Association for the Advancement of Science (AAAS), 2023)
    We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 ...
  • Christmas, Matthew J.; Valenzuela, Alejandro; Marquès i Bonet, Tomàs, 1975-; Navarro i Cuartiellas, Arcadi, 1969-; Karlsson, Elinor K. (American Association for the Advancement of Science (AAAS), 2023)
    Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and alter disease risk. At least ...
  • Naranjo-Ortíz, Miguel A.; Brock, Matthias; Brunke, Sascha; Hube, Bernhard; Marcet Houben, Marina; Gabaldón Estevan, Juan Antonio, 1973- (Frontiers, 2016)
    Analysis of the growing number of available fully-sequenced genomes has shown that Horizontal Gene Transfer (HGT) in eukaryotes is more common than previously thought. It has been proposed that genes with certain functions ...
  • Nachshon, Aharon; Abu-Toamih Atamni, Hanifa Jalal; Steuerman, Yael; Sheikh-Hamed, Roa'a; Dorman, Alexandra; Mott, Richard; Dohm, Juliana C.; Lehrach, Hans; Sultan, Marc; Shamir, Ron; Sauer, Sascha; Himmelbauer, Heinz; Iraqi, Fuad A.; Gat-Viks, Irit (Frontiers, 2016)
    A central challenge in pharmaceutical research is to investigate genetic variation in response to drugs. The Collaborative Cross (CC) mouse reference population is a promising model for pharmacogenomic studies because of ...
  • Murakami, Tetsuro; Gaetano Tartaglia, Gian; George-Hyslop, Peter St (Cell Press, 2015)
    The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS and FTD remain controversial. We propose a model in which low-complexity (LC) domains of FUS drive its physiologically reversible assembly ...
  • Meijer, Harold J. G.; Mancuso, Francesco M.; Espadas, Guadalupe; Seidl, Michael F.; Chiva, Cristina; Govers, Francine; Sabidó Aguadé, Eduard, 1981- (American Society for Biochemistry and Molecular Biology (ASBMB), 2014)
    Oomycetes are filamentous organisms that cause notorious diseases, several of which have a high economic impact. Well known is Phytophthora infestans, the causal agent of potato late blight. Previously, in silico analyses ...
  • Wilder, Aryn P.; Supple, Megan A.; Subramanian, Ayshwarya; Mudide, Anish; Swofford, Ross; Serres-Armero, Aitor; Steiner, Cynthia; Koepfli, Klaus-Peter; Genereux, Diane P.; Karlsson, Elinor K.; Lindblad-Toh, Kerstin; Marquès i Bonet, Tomàs, 1975-; Muñoz-Fuentes, Violeta; Foley, Kathleen; Meyer, Wynn K.; Zoonomia Consortium; Ryder, Oliver A.; Shapiro, Beth (American Association for the Advancement of Science (AAAS), 2023)
    Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. In this study, we surveyed genetic ...
  • Kaplow, Irene M.; Lawler, Alyssa J.; Schäffer, Daniel E.; Srinivasan, Chaitanya; Sestili, Heather H.; Wirthlin, Morgan E.; Phan, BaDoi N.; Prasad, Kavya; Brown, Ashley; Zhang, Xiaomeng; Foley, Kathleen; Genereux, Diane P.; Zoonomia Consortium; Karlsson, Elinor K.; Lindblad-Toh, Kerstin; Meyer, Wynn K.; Pfenning, Andreas R. (American Association for the Advancement of Science (AAAS), 2023)
    Protein-coding differences between species often fail to explain phenotypic diversity, suggesting the involvement of genomic elements that regulate gene expression such as enhancers. Identifying associations between enhancers ...
  • Kirilenko, Bogdan M.; Munegowda, Chetan; Osipova, Ekaterina; Jebb, David; Sharma, Virag; Blumer, Moritz; Morales, Ariadna E.; Ahmed, Alexis-Walid; Kontopoulos, Dimitrios-Georgios; Hilgers, Leon; Lindblad-Toh, Kerstin; Karlsson, Elinor K.; Zoonomia Consortium; Hiller, Michael (American Association for the Advancement of Science (AAAS), 2023)
    Annotating coding genes and inferring orthologs are two classical challenges in genomics and evolutionary biology that have traditionally been approached separately, limiting scalability. We present TOGA (Tool to infer ...
  • Xue, James R.; Mackay-Smith, Ava; Mouri, Kousuke; Fernandez Garcia, Meilin; Dong, Michael X.; Akers, Jared F.; Noble, Mark; Li, Xue; Zoonomia Consortium; Lindblad-Toh, Kerstin; Karlsson, Elinor K.; Noonan, James P.; Capellini, Terence D.; Brennand, Kristen J.; Tewhey, Ryan; Sabeti, Pardis C.; Reilly, Steven K. (American Association for the Advancement of Science (AAAS), 2023)
    Conserved genomic sequences disrupted in humans may underlie uniquely human phenotypic traits. We identified and characterized 10,032 human-specific conserved deletions (hCONDELs). These short (average 2.56 base pairs) ...
  • Sullivan, Patrick F.; Zoonomia Consortium; Lindblad-Toh, Kerstin (American Association for the Advancement of Science (AAAS), 2023)
    Thousands of genomic regions have been associated with heritable human diseases, but attempts to elucidate biological mechanisms are impeded by an inability to discern which genomic positions are functionally important. ...
  • Baquero Pérez, Belinda; Yonchev, Ivaylo D.; Delgado-Tejedor, Anna; Medina, Rebeca; Puig-Torrents, Mireia; Sudbery, Ian; Begik, Oguzhan; Wilson, Stuart A.; Novoa, Eva Maria; Díez Antón, Juana, 1962- (Nature Research, 2024)
    Despite the nuclear localization of the m6A machinery, the genomes of multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively m6A-modified. However, these ...
  • Baune, Bernhard T.; Domínguez Barragán, Jorge; Donlo, Chus; Martínez de Lagrán Cabredo, María; Mayer, Miguel Ángel, 1960-; Perera Bel, Júlia; Sierra, Cesar; Sanz, Ferran; Dierssen, Mara (Frontiers, 2024)
    Major depressive disorder (MDD) is the most common psychiatric disease worldwide with a huge socio-economic impact. Pharmacotherapy represents the most common option among the first-line treatment choice; however, only ...
  • González-Casanova, Adrián; Miró Pina, Verónica; Schertzer, Emmanuel; Siri-Jégousse, Arno (Institute of Mathematical Statistics, 2024)
    In this work, we study general Dirichlet coalescents, which are a family of Ξ-coalecents constructed from i.i.d mass partitions, and are an extension of the symmetric coalescent. This class of models is motivated by ...
  • Fromont, Lauren A.; Moldes, Mauricio; Baudis, Michael; Brookes, Anthony J.; Navarro i Cuartiellas, Arcadi, 1969-; Rambla de Argila, Jordi (Public Library of Science (PLoS), 2024)
  • Masgrau Fortuny, Aina, 1986-; Battola, Andrea, 1987-; Sanmartín Olmo, Trinidad; Pryszcz, Leszek Piotr, 1985-; Gabaldón Estevan, Juan Antonio, 1973-; Mendoza, Manuel (Mendoza Palomares) (American Society for Cell Biology, 2017)
    Boi1 and Boi2 (Boi1/2) are budding yeast plasma membrane proteins that function in polarized growth, and in cytokinesis inhibition in response to chromosome bridges via the NoCut abscission checkpoint. How Boi1/2 act in ...

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