Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Pinto-Teixeira, Filipo; Muzzopappa, Mariana; Swoger, Jim; Mineo, Alessandro; Sharpe, James; López-Schier, Hernán (Frontiers, 2013)
    Direct videomicroscopic visualization of organ formation and regeneration in toto is a powerful strategy to study cellular processes that often cannot be replicated in vitro. Intravital imaging aims at quantifying changes ...
  • Pryszcz, Leszek Piotr, 1985-; Németh, Tibor; Saus Martínez, Ester; Ksiezopolska, Ewa; Hegedűsová, Eva; Nosek, Jozef; Wolfe, Kenneth H.; Gacser, Attila; Gabaldín Estevan, Juan Antonio, 1973- (Public Library of Science (PLoS), 2015)
    Candida metapsilosis is a rarely-isolated, opportunistic pathogen that belongs to a clade of pathogenic yeasts known as the C. parapsilosis sensu lato species complex. To gain insight into the recent evolution of C. ...
  • Percy, Andrew J.; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Borchers, Christoph H. (Elsevier, 2015)
    The reproducibility of plasma protein quantitation between laboratories and between instrument types was examined in a large-scale international study involving 16 laboratories and 19 LC–MS/MS platforms, using two kits ...
  • Titos Vivancos, Iris; Ivanova, Tsvetomira Georgieva, 1978-; Mendoza, Manuel (Mendoza Palomares) (Rockefeller University Press, 2014)
    To allow chromosome segregation, topoisomerase II (topo II) must resolve sister chromatid intertwines (SCI) formed during deoxynucleic acid (DNA) replication. How this process extends to the full genome is not well understood. ...
  • Supek, Fran; Lehner, Ben, 1978-; Hajkova, Petra; Warnecke, Tobias (Public Library of Science (PLoS), 2014)
    It has long been known that methylated cytosines deaminate at higher rates than unmodified cytosines and constitute mutational hotspots in mammalian genomes. The repertoire of naturally occurring cytosine modifications, ...
  • Storer, Mekayla, 1981-; Keyes, William M., 1973- (Taylor & Francis, 2014)
    Cellular senescence is an irreversible form of cell cycle arrest that has been linked to several pathological conditions. In particular, senescence can function as a tumor suppressor mechanism, but is also thought to ...
  • Stefos, Georgios C.; Soppa, Ulf; Dierssen Sotos, Mara; Becker, Walter (Public Library of Science (PLoS), 2013)
    Background. Plasminogen activator inhibitor 1 (PAI-1) is a key regulator of the plasminogen activation system. Although several lines of evidence support a significant role of PAI-1 in the brain, the regulation of its ...
  • Park, Solip; Lehner, Ben, 1978- (EMBO Press, 2013)
    Reduced activity of two genes in combination often has a more detrimental effect than expected. Such epistatic interactions not only occur when genes are mutated but also due to variation in gene expression, including among ...
  • Diensthuber, Gregor; Pryszcz, Leszek Piotr, 1985-; Llovera Nadal, Laia; Lucas, Morghan C.; Delgado-Tejedor, Anna; Cruciani, Sonia; Roignant, Jean-Yves; Begik, Oguzhan; Novoa, Eva Maria (Cold Spring Harbor Laboratory Press (CSHL Press), 2024)
    In recent years, nanopore direct RNA sequencing (DRS) became a valuable tool for studying the epitranscriptome, due to its ability to detect multiple modifications within the same full-length native RNA molecules. While ...
  • Massafret, Ot; Barragán, Montserrat; Álvarez-González, Lucía; Aran, Begoña; Martín-Mur, Beatriz; Esteve-Codina, Anna; Ruiz Herrera, Aurora; Ibáñez, Elena; Santaló, Josep (Elsevier, 2024)
    Human embryonic stem cells (hESCs) derived from blastocyst stage embryos present a primed state of pluripotency, whereas mouse ESCs (mESCs) display naïve pluripotency. Their unique characteristics make naïve hESCs more ...
  • Naderi, Julian; Magalhaes, Alexandre P.; Kibar, Gözde; Stik, Grégoire; Zhang, Yaotian; Mackowiak, Sebastian D.; Wieler, Hannah M.; Rossi, Francesca; Buschow, Rene; Christou-Kent, Marie; Alcoverro-Bertran, Marc; Graf, T. (Thomas); Vingron, Martin; Hnisz, Denes (Nature Research, 2024)
    Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is unclear. Here we provide evidence for an evolutionary trade-off between ...
  • Warmenhoven, Noëlle; Sánchez Benavides, Gonzalo; González Escalante, Armand; Milà Alomà, Marta; Shekari, Mahnaz; López Martos, David; Ortiz Romero, Paula, 1994-; Kollmorgen, Gwendlyn; Quijano Rubio, Clara; Minguillón, Carolina; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Palpatzis, Eleni; Ashton, Nicholas J.; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Grau-Rivera, Oriol; ALFA Study (Wiley, 2024)
    Introduction: We examined whether baseline glial markers soluble triggering receptor expressed on myeloid cell 2 (sTREM2), chitinase 3-like protein 1 (YKL-40), and glial fibrillary acidic protein (GFAP) in cerebrospinal ...
  • Ilic, Nikola; Maric, Nina; Maver, Ales; Armengol i Dulcet, Lluís; Kravljanac, Ruzica; Cirkovic, Jana; Krstic, Jovana; Radivojevic, Danijela; Cirkovic, Sanja; Ostojic, Slavica; Krasic, Stasa; Paripovic, Aleksandra; Vukomanovic, Vladislav; Peterlin, Borut; Maric, Gorica; Sarajlija, Adrijan (MDPI, 2024)
    This study delves into the diagnostic yield of whole-exome sequencing (WES) in pediatric patients presenting with developmental delay/intellectual disability (DD/ID), while also exploring the utility of Reverse Phenotyping ...
  • Pereira, Brooke A.; Lucas, Morghan C.; Timpson, Paul (American Association for the Advancement of Science (AAAS), 2024)
    Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome of the highly metastatic ...
  • Sandoval Velasco, Marcela; Martí Renom, Marc A.; Lieberman Aiden, Erez (Elsevier, 2024)
    Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides and aligning to genome assemblies from related, modern species. Here, we report that skin from a female woolly mammoth (†Mammuthus ...
  • Sarre, Luke A.; Kim, Iana V.; Ovchinnikov, Vladimir; Olivetta, Marine; Suga, Hiroshi; Dudin, Omaya; Sebé-Pedrós, Arnau; Mendoza, Alex de (American Association for the Advancement of Science (AAAS), 2024)
    5-Methylcytosine (5mC) is a widespread silencing mechanism that controls genomic parasites. In eukaryotes, 5mC has gained complex roles in gene regulation beyond parasite control, yet 5mC has also been lost in many lineages. ...
  • Flormann, Daniel; Kainka, Lucina; Montalvo, Gala; Rheinlaender, Johannes; Thalla, D.; Vesperini, Doriane; Pohland, M. O.; Kaub, K. H.; Schu, M.; Pezzano, Fabio; Ruprecht, Verena; Terriac, Emmanuel; Hawkins, Rhoda; Lautenschläger, Franziska (National Academy of Sciences, 2024)
    Cells exist in different phenotypes and can transition between them. A phenotype may be characterized by many different aspects. Here, we focus on the example of whether the cell is adhered or suspended and choose particular ...
  • Bustamante Pineda, Mariona; Balagué-Dobón, Laura; Casas Sanahuja, Maribel; Maitre, Léa; Nurtdinov, Ramil; González, Juan Ramón; Vrijheid, Martine (Elsevier, 2024)
    Introduction: Phthalates, or dieters of phthalic acid, are a ubiquitous type of plasticizer used in a variety of common consumer and industrial products. They act as endocrine disruptors and are associated with increased ...
  • Camilleri Robles, Carlos; Amador, Raziel; Tiebe, Marcel; Teleman, Aurelio A.; Serras, Florenci; Guigó Serra, Roderic; Corominas Guiu, Montserrat (Oxford University Press, 2024)
    The discovery of functional long non-coding RNAs (lncRNAs) changed their initial concept as transcriptional noise. LncRNAs have been identified as regulators of multiple biological processes, including chromatin structure, ...
  • Baquero Pérez, Belinda; Bortoletto, Enrico; Rosani, Umberto; Delgado-Tejedor, Anna; Medina, Rebeca; Novoa, Eva Maria; Venier, Paola; Díez Antón, Juana, 1962- (MDPI, 2024)
    The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus ...

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