Browsing Center for Genomic Regulation (CRG) by Subject "X-ray crystallography"

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Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae

Vizarraga, David; Mazzolini, Rocco; Lluch-Senar, Maria 1982-; Aparicio, David (Nature Research, 2020)

Mycoplasma pneumoniae is a bacterial human pathogen that causes primary atypical pneumonia. M. pneumoniae motility and infectivity are mediated by the immunodominant proteins P1 and P40/P90, which form a transmembrane ...
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

Errasti-Murugarren, Ekaitz; Fort, Joana; Bartoccioni, Paola; Díaz, Lucía; Pardon, Els; Carpena, Xavier; Espino Guarch, Meritxell; Zorzano, Antonio; Ziegler, Christine; Steyaert, Jan; Fernández Recio, Juan; Fita, Ignacio; Palacín Mateo, Manuel (Nature Research, 2019)

L-amino acid transporters (LATs) play key roles in human physiology and are implicated in several human pathologies. LATs are asymmetric amino acid exchangers where the low apparent affinity cytoplasmic side controls the ...
The unravelling of the complex pattern of tyrosinase inhibition

Deri, Batel; Kanteev, Margarita; Goldfeder, Mor; Lecina, Daniel; Guallar i Tasies, Víctor; Adir, Noam; Fishman, Ayelet (Nature Publishing Group, 2016)

Tyrosinases are responsible for melanin formation in all life domains. Tyrosinase inhibitors are used for the prevention of severe skin diseases, in skin-whitening creams and to avoid fruit browning, however continued use ...

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