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Browsing Center for Genomic Regulation (CRG) by Subject "Transcription factor"

Browsing Center for Genomic Regulation (CRG) by Subject "Transcription factor"

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  • Alternative transcriptional regulation in genome-reduced bacteria
    Miravet Verde, Samuel, 1992-; Lloréns Rico, Verónica, 1989-; Serrano Pubull, Luis, 1982- (Elsevier, 2017)
    Transcription is a core process of bacterial physiology, and as such it must be tightly controlled, so that bacterial cells maintain steady levels of each RNA molecule in homeostasis and modify them in response to ...
  • Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity
    Torcal Garcia, Guillem, 1991-; Kowenz-Leutz, Elisabeth; Tian, Tian V.; Klonizakis, Antonios; Lerner, Jonathan; Andrés Aguayo, Luisa de; Sapozhnikova, Valeriia; Berenguer, Clara; Plana Carmona, Marcos, 1993-; Vila-Casadesús, Maria; Bulteau, Romain; Francesconi, Mirko; Peiró Sales, Sandra; Mertins, Philipp; Zaret, Kenneth S.; Leutz, Achim; Graf, T. (Thomas) (eLife, 2023)
    Here, we describe how the speed of C/EBPα-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. The identification of a mutant of C/EBPα (C/EBPαR35A) that greatly ...
  • Stochastic particle unbinding modulates growth dynamics and size of transcription factor condensates in living cells
    Muñoz-Gil, Gorka; Romero-Aristizabal, Catalina; Mateos, Nicolas; Campelo, Felix; De Llobet, Lara Isabel; Beato, Miguel; Lewenstein, Maciej; Garcia-Parajo, Maria F.; Torreno-Pina, Juan A. (National Academy of Sciences, 2022)
    Liquid-liquid phase separation (LLPS) is emerging as a key physical principle for biological organization inside living cells, forming condensates that play important regulatory roles. Inside living nuclei, transcription ...
  • The transcription factor code: a beacon for histone methyltransferase docking
    Torcal Garcia, Guillem, 1991-; Graf, T. (Thomas) (Elsevier, 2021)
    Histone methylation is required for the establishment and maintenance of gene expression patterns that determine cellular identity, and its perturbation often leads to aberrant development and disease. Recruitment of histone ...

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