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Browsing Center for Genomic Regulation (CRG) by Subject "Transcription"

Browsing Center for Genomic Regulation (CRG) by Subject "Transcription"

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  • Yus, Eva; Yang, Jae-Seong; Sogues, Adrià; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2017)
    Quantitative analysis of the sequence determinants of transcription and translation regulation is relevant for systems and synthetic biology. To identify these determinants, researchers have developed different methods of ...
  • Reim, Alexander; Ackermann, Roland; Font Mateu, Jofre, 1977-; Kammel, Robert; Beato, Miguel; Nolte, Stefan; Mann, Matthias; Russmann, Christoph; Wierer, Michael, 1982- (Nature Research, 2020)
    Transcription factors (TFs) regulate target genes by specific interactions with DNA sequences. Detecting and understanding these interactions at the molecular level is of fundamental importance in biological and clinical ...
  • Villaverde, Alejandro F; Henriques, David; Smallbone, Kieran; Bongard, Sophia; Schmid, Joachim; Cicin Sain, Damjan; Crombach, Anton; Sáez Rodríguez, Julio; Mauch, Klaus; Balsa Canto, Eva; Mendes, Pedro; Jaeger, Johannes, 1973-; Banga, Julio R. (BioMed Central, 2015)
    Background: Dynamic modelling is one of the cornerstones of systems biology. Many research efforts are currently being invested in the development and exploitation of large-scale kinetic models. The associated problems of ...
  • Bauer, Moritz, 1987-; Payer, Bernhard; Filion, Guillaume (Wiley, 2022)
    The spatial organization of genomes is becoming increasingly understood. In mammals, where it is most investigated, this organization ties in with transcription, so an important research objective is to understand whether ...
  • Christou-Kent, Marie; Cuartero, Sergi; Garcia-Cabau, Carla; Ruehle, Julia; Naderi, Julian; Erber, Julia; Neguembor, Maria Victoria; Plana Carmona, Marcos, 1993-; Alcoverro-Bertran, Marc; Andrés Aguayo, Luisa de; Klonizakis, Antonios; Julià Vilella, Eric; Lynch, Cian J.; Serrano, Manuel; Hnisz, Denes; Salvatella, Xavier; Graf, T. (Thomas); Stik, Grégoire (Elsevier, 2023)
    Cell identity is orchestrated through an interplay between transcription factor (TF) action and genome architecture. The mechanisms used by TFs to shape three-dimensional (3D) genome organization remain incompletely ...
  • Robles-Rebollo, Irene; Cuartero, Sergi; Canellas-Socias, Adria; Wells, Sarah; Karimi, Mohammad M.; Mereu, Elisabetta; Chivu, Alexandra G.; Heyn, Holger; Whilding, Chad; Dormann, Dirk; Marguerat, Samuel; Rioja, Inmaculada; Prinjha, Rab K.; Stumpf, Michael P.H.; Fisher, Amanda G.; Merkenschlager, Matthias (Nature Research, 2022)
    Innate immune responses rely on inducible gene expression programmes which, in contrast to steady-state transcription, are highly dependent on cohesin. Here we address transcriptional parameters underlying this cohesin-dependence ...
  • Lin, Xin-Xuan; Sen, Ilke; Janssens, Georges E.; Zhou, Xin; Fonslow, Bryan R.; Edgar, Daniel; Stroustrup, Nicholas; Swoboda, Peter; Yates, John R.; Ruvkun, Gary; Riedel, Christian G. (Nature Research, 2018)
    The ability to perceive and respond to harmful conditions is crucial for the survival of any organism. The transcription factor DAF-16/FOXO is central to these responses, relaying distress signals into the expression of ...
  • Tilgner, Hagen, 1980-; Guigó Serra, Roderic (Taylor & Francis (Routledge), 2010)
    RNA plays a central role in the determination of the phenotype of the cell. The molecular mechanisms involved in primary RNA synthesis and subsequent post-processing are not completely understood, but there is increasing ...
  • Vives Usano, Marta, 1990-; Hernández-Ferrer, Carles; Maitre, Léa; Ruiz Arenas, Carlos, 1990-; Borràs, Eva; Casas Sanahuja, Maribel; Estivill, Xavier, 1955-; González, Juan Ramón; Sabidó Aguadé, Eduard, 1981-; Vrijheid, Martine; Bustamante Pineda, Mariona (BioMed Central, 2020)
    Background: The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite of this, the underlying molecular mechanisms of in utero and postnatal exposure to tobacco smoke are only ...
  • Di Vona, Chiara, 1981-; Barba Moreno, Laura, 1989-; Ferrari, Roberto; Luna, Susana de la (MDPI, 2023)
    Ribosomal proteins (RPs) are evolutionary conserved proteins that are essential for protein translation. RP expression must be tightly regulated to ensure the appropriate assembly of ribosomes and to respond to the growth ...
  • Gentsch, George E.; Spruce, Thomas; Owens, Nick D.L.; Smith, James (Nature Research, 2019)
    Embryonic development yields many different cell types in response to just a few families of inductive signals. The property of signal-receiving cells that determines how they respond to inductive signals is known as ...
  • Curado, Joao; Iannone, Camilla, 1984-; Tilgner, Hagen, 1980-; Valcárcel, J. (Juan); Guigó Serra, Roderic (BioMed Central, 2015)
    Background. Pre-mRNA splicing occurs mainly co-transcriptionally, and both nucleosome density and histone modifications have been proposed to play a role in splice site recognition and regulation. However, the extent and ...
  • Martínez-Moro, Álvaro; González-Brusi, Leopoldo; Lamas-Toranzo, Ismael; O'Callaghan, Elena; Esteve-Codina, Anna; Lonergan, Pat; Bermejo-Álvarez, Pablo (Wiley, 2022)
    Cumulus cells provide an interesting biological material to perform analyses to understand the molecular clues determining oocyte competence. The objective of this study was to analyze the transcriptional differences between ...
  • Neguembor, Maria Victoria; Martin, Laura; Castells García, Àlvaro, 1991-; Gómez García, Pablo; Vicario, Chiara; Carnevali, Davide; Abed, Jumana AlHaj; Granados, Alba; Sebastián Pérez, Rubén; Sottile, Francesco, 1988-; Solon, Jérôme; Wu, Chao-Ting; Lakadamyali, Melike; Cosma, Maria Pia, 1970- (Elsevier, 2021)
    The chromatin fiber folds into loops, but the mechanisms controlling loop extrusion are still poorly understood. Using super-resolution microscopy, we visualize that loops in intact nuclei are formed by a scaffold of cohesin ...
  • Martin, Laura; Neguembor, Maria Victoria; Cosma, Maria Pia, 1970- (Frontiers, 2023)
    One of the biggest paradoxes in biology is that human genome is roughly 2 m long, while the nucleus containing it is almost one million times smaller. To fit into the nucleus, DNA twists, bends and folds into several ...
  • Aloia, Luigi; Demajo Meseguer, Santiago, 1985-; Di Croce, Luciano (Taylor & Francis (Routledge), 2015)
    The Zuotin-related factor 1, ZRF1, has recently been identified as an epigenetic regulator of gene transcription in stem cells and cancer. During differentiation of human teratocarcinoma cells, ZRF1 promotes transcriptional ...

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