Browsing Center for Genomic Regulation (CRG) by Subject "Somatic cell reprogramming"

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Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1

Vivori, Claudia, 1989-; Papasaikas, Panagiotis; Stadhouders, Ralph; Di Stefano, Bruno, 1984-; Ribó Rubio, Anna; Berenguer, Clara; Generoso, Serena Francesca, 1988-; Mallol, Anna; Sardina, Jose Luis; Payer, Bernhard; Graf, T. (Thomas); Valcárcel, J. (Juan) (BioMed Central, 2021)

Background: Somatic cell reprogramming is the process that allows differentiated cells to revert to a pluripotent state. In contrast to the extensively studied rewiring of epigenetic and transcriptional programs required ...
The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling

Plana-Carmona, Marcos; Stik, Grégoire; Bulteau, Romain; Segura-Morales, Carolina; Alcázar, Noelia; Wyatt, Christopher Douglas Robert, 1988-; Klonizakis, Antonios; Andrés Aguayo, Luisa de; Gasnier, Maxime; Tian, Tian V.; Torcal Garcia, Guillem, 1991-; Vila-Casadesús, Maria; Plachta, Nicolas; Serrano, Manuel; Francesconi, Mirko; Graf, T. (Thomas) (Elsevier, 2022)

IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how Il6 expression is regulated and whether it plays a role during embryo development remains unknown. ...

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