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Browsing Center for Genomic Regulation (CRG) by Subject "Single-cell RNA sequencing"

Browsing Center for Genomic Regulation (CRG) by Subject "Single-cell RNA sequencing"

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  • CRISPR activation enables high-fidelity reprogramming into human pluripotent stem cells
    Sokka, Joonas; Yoshihara, Masahito; Kvist, Jouni; Laiho, Laura; Warren, Andrew; Stadelmann, Christian; Jouhilahti, Eeva-Mari; Kilpinen, Helena; Balboa, Diego; Katayama, Shintaro; Kyttälä, Aija; Kere, Juha; Otonkoski, Timo; Weltner, Jere; Trokovic, Ras (Elsevier, 2022)
    Conventional reprogramming methods rely on the ectopic expression of transcription factors to reprogram somatic cells into induced pluripotent stem cells (iPSCs). The forced expression of transcription factors may lead to ...
  • scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
    Schäfer, Samuel; Smelik, Martin; Sysoev, Oleg; Zhao, Yelin; Eklund, Desiré; Lilja, Sandra; Gustafsson, Mika; Heyn, Holger; Julià, Antonio; Kovács, István A.; Loscalzo, Joseph; Marsal Barril, Sara; Zhang, Huan; Li, Xinxiu; Gawel, Danuta; Wang, Hui; Benson, Mikael (BioMed Central, 2024)
    Background: Ineffective drug treatment is a major problem for many patients with immune-mediated inflammatory diseases (IMIDs). Important reasons are the lack of systematic solutions for drug prioritisation and repurposing ...
  • Single-cell transcriptional changes in neurodegenerative diseases
    Ahmadi, Amirhossein; Gispert López, Juan Domingo; Navarro i Cuartiellas, Arcadi, 1969-; Vilor Tejedor, Natàlia, 1988-; Sadeghi, Iman (Elsevier, 2021)
    In recent decades, our understanding of the molecular changes involved in neurodegenerative diseases has been transformed. Single-cell RNA sequencing and single-nucleus RNA sequencing technologies have been applied to ...

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