Browsing Center for Genomic Regulation (CRG) by Subject "Kinases"

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Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations

Kuzmanic, Antonija; Sutto, Ludovico; Saladino, Giorgio; Nebreda, Ángel R.; Gervasio, Francesco L.; Orozco, Modesto (eLife, 2017)

p38α is a Ser/Thr protein kinase involved in a variety of cellular processes and pathological conditions, which makes it a promising pharmacological target. Although the activity of the enzyme is highly regulated, its ...
FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2

Jiménez-Izquierdo, Rafael; Morrugares, Rosario; Suanes-Cobos, Lucía; Correa-Sáez, Alejandro; Garrido-Rodríguez, Martín; Cerero-Tejero, Laura; Khan, Omar M.; Luna, Susana de la; Sancho, Rocío; Calzado, Marco A. (Springer, 2023)

FBXW7 is a member of the F-box protein family, which functions as the substrate recognition component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated ...

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