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Browsing Center for Genomic Regulation (CRG) by Subject "JAK2"

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MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer

Alburquerque-Bejar, Juan J.; Navajas-Chocarro, Pablo; Saigi, Maria; Ferrero-Andrés, Ana; Morillas, Juan M.; Vilarrubi, Andrea; Gómez, Antonio; Mate, José Luís; Muñoz-Mármol, Ana M.; Romero, Octavio A.; Blecua, Pedro; Davalos, Veronica; Esteller, Manel; Pros, Eva; Llabata, Paula; Torres-Diz, Manuel; Esteve-Codina, Anna; Sánchez Céspedes, Montse (Elsevier, 2023)

Elucidating the adaptive mechanisms that prevent host immune response in cancer will help predict efficacy of anti-programmed death-1 (PD1)/L1 therapies. Here, we study the cell-intrinsic response of lung cancer (LC) to ...

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