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Browsing Center for Genomic Regulation (CRG) by Subject "Factors de transcripció"

Browsing Center for Genomic Regulation (CRG) by Subject "Factors de transcripció"

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  • HDAC7 is a repressor of myeloid genes whose downregulation is required for transdifferentiation of pre-B cells into macrophages
    Barneda Zahonero, Bruna; Román González, Lidia; Collazo, Olga; Rafati, Haleh; Islam, Abul, 1978-; Bussmann, Lars; Di Tullio, Alessandro, 1982-; Andrés, Luisa De; Graf, T. (Thomas); López Bigas, Núria; Mahmoudi, Tokameh; Parra, Maribel (Public Library of Science (PLoS), 2013)
    B lymphopoiesis is the result of several cell-commitment, lineage-choice, and differentiation processes. Every differentiation step is characterized by the activation of a new, lineage-specific, genetic program and the ...
  • Long noncoding RNAs with enhancer-like function in human cells
    Orom, Ulf Andersson; Derrien, Thomas; Beringer, Malte; Gumireddy, Kiranmai; Gardini, Alessandro; Bussotti, Giovanni, 1983-; Lai, Fan; Zytnicki, Matthias; Notredame, Cedric; Huang, Qihong; Guigó Serra, Roderic; Shiekhattar, Ramin (Elsevier, 2010)
    While the long noncoding RNAs (ncRNAs) constitute a large portion of the mammalian transcriptome, their biological functions has remained elusive. A few long ncRNAs that have been studied in any detail silence gene expression ...
  • miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate
    Ji, Yun; Di Croce, Luciano; Gattinoni, Luca (Nature Research, 2019)
    T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8+ T cell antitumor function by restraining T cell senescence and functional exhaustion through ...
  • A novel common variant in DCST2 is associated with length in early life and height in adulthood
    van der Valk, Ralf J.P.; Guxens Junyent, Mònica; EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium; Bustamante Pineda, Mariona; Estivill, Xavier, 1955-; González Ruiz, Juan Ramón; Sunyer Deu, Jordi; Early Growth Genetics (EGG) Consortium (Oxford University Press, 2015)
    Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we ...

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