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Browsing Center for Genomic Regulation (CRG) by Subject "ADN -- Metilació"

Browsing Center for Genomic Regulation (CRG) by Subject "ADN -- Metilació"

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  • Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics
    Tierling, Sascha; Jürgens-Wemheuer, Wiebke M.; Leismann, Alea; Becker-Kettern, Julia; Scherer, Michael; Wrede, Arne; Breuskin, David; Urbschat, Steffi; Sippi, Christoph; Oertel, Joachim; Schulz-Schaeffer, Walter J.; Walter, Jörn (BioMed Central, 2022)
    Background: Promoter methylation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is an acknowledged predictive epigenetic marker in glioblastoma multiforme and anaplastic astrocytoma. Patients with ...
  • DeepMP: a deep learning tool to detect DNA base modifications on Nanopore sequencing data
    Bonet, Jose; Chen, Mandi; Dabad, Marc; Heath, Simon; Gonzalez-Perez, Abel; López Bigas, Núria; Lagergren, Jens (Oxford University Press, 2021)
    Motivation: DNA Methylation plays a key role in a variety of biological processes. Recently, Nanopore long-read sequencing has enabled direct detection of these modifications. As a consequence, a range of computational ...
  • E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
    Dahlet, Thomas; Truss, Matthias; Frede, Ute; Al Adhami, Hala; Bardet, Anaïs F.; Dumas, Michael; Vallet, Judith; Chicher, Johana; Hammann, Philippe; Kottnik, Sarah; Hansen, Peter; Luz, Uschi; Alvarez, Gonzalo; Auclair, Ghislain; Hecht, Jochen; Robinson, Peter N.; Hagemeier, Christian; Weber, Michael (Nature Research, 2021)
    In mouse development, long-term silencing by CpG island DNA methylation is specifically targeted to germline genes; however, the molecular mechanisms of this specificity remain unclear. Here, we demonstrate that the ...
  • Prenatal particulate air pollution and DNA methylation in newborns: an epigenome-wide meta-analysis
    Gruzieva, Olena; Kogevinas, Manolis; Ruiz, José L.; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Vrijheid, Martine; Hernandez-Ferrer, Carles, 1987-; Melén, Erik (National Institute of Environmental Health Sciences (NIEHS), 2019)
    BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed ...
  • Storage conditions and stability of global DNA methylation in placental tissue
    Vilahur Chiaraviglio, Nadia, 1982-; Baccarelli, Andrea A.; Bustamante Pineda, Mariona; Agramunt, Silvia; Byun, Hyang-Min; Fernandez, Mariana F.; Sunyer Deu, Jordi; Estivill, Xavier, 1955- (Future Medicine, 2013)
    AIM: The placenta is an informative and easily available tissue for many epidemiological studies. We analyzed the extent to which storage delay affects DNA methylation. MATERIAL & METHODS: Biopsies from two placentas were ...
  • The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
    Carreras-Gallo, Natàlia; Cáceres, Alejandro; Balagué-Dobón, Laura; Ruiz-Arenas, Carlos; Casas Sanahuja, Maribel; Maitre, Léa; Nieuwenhuijsen, Mark J.; Stratakis, Nikos; Urquiza, José M.; Bustamante Pineda, Mariona; Vrijheid, Martine; Pérez Jurado, Luis Alberto; Gonzalez, Juan Ramon (Nature Research, 2022)
    Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three ...

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