Browsing Center for Genomic Regulation (CRG) by Subject "β-catenin"

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Canonical Wnt pathway controls mESC self-renewal through inhibition of spontaneous differentiation via β-catenin/TCF/LEF functions

Aulicino, Francesco, 1987-; Pedone, Elisa, 1985-; Sottile, Francesco, 1988-; Lluis Vinas, Frederic; Marucci, Lucia; Cosma, Maria Pia (Elsevier, 2020)

The Wnt/β-catenin signaling pathway is a key regulator of embryonic stem cell (ESC) self-renewal and differentiation. Constitutive activation of this pathway has been shown to increase mouse ESC (mESC) self-renewal and ...
β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia

García Hernández, Violeta; Arambilet, David; Guillén, Yolanda; Lobo-Jarne, Teresa; Maqueda, Maria; Gekas, Christos; González, Jessica; Iglesias, Arnau; Vega García, Nerea; Sentís Carreras, Inés 1990-; Trincado Alonso, Juan Luis, 1987-; Márquez-López, Ian; Heyn, Holger; Camós, Mireia; Espinosa Blay, Lluís; Bigas Salvans, Anna (Wiley, 2023)

Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the ...

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