Browsing Center for Genomic Regulation (CRG) by Author "Walter, Jörn"

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Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics

Tierling, Sascha; Jürgens-Wemheuer, Wiebke M.; Leismann, Alea; Becker-Kettern, Julia; Scherer, Michael; Wrede, Arne; Breuskin, David; Urbschat, Steffi; Sippi, Christoph; Oertel, Joachim; Schulz-Schaeffer, Walter J.; Walter, Jörn (BioMed Central, 2022)

Background: Promoter methylation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is an acknowledged predictive epigenetic marker in glioblastoma multiforme and anaplastic astrocytoma. Patients with ...
Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR

Scherer, Michael; Gasparoni, Gilles; Rahmouni, Souad; Shashkova, Tatiana; Arnoux, Marion; Louis, Edward J.; Nostaeva, Arina; Avalos, Diana; Dermitzakis, Emmanuouil T.; Aulchenko, Yurii S.; Lengauer, Thomas; Lyons, Paul A.; Georges, Michel; Walter, Jörn (BioMed Central, 2021)

Background: Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for ...

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