Welcome to the UPF Digital Repository

Browsing Center for Genomic Regulation (CRG) by Author "Valcárcel, J. (Juan)"

Browsing Center for Genomic Regulation (CRG) by Author "Valcárcel, J. (Juan)"

Sort by: Order: Results:

  • Torres Méndez, Antonio; Bonnal, Sophie; Marquez, Yamile; Roth, Jonathan; Iglesias, Marta; Permanyer, Jon; Almudi, Isabel; O'Hanlon, Dave; Guitart, Tanit; Soller, Matthias; Gingras, Anne-Claude; Gebauer, Fátima; Rentzsch, Fabian; Blencowe, Benjamin J.; Valcárcel, J. (Juan); Irimia Martínez, Manuel (Nature Research, 2019)
    The mechanisms by which entire programmes of gene regulation emerged during evolution are poorly understood. Neuronal microexons represent the most conserved class of alternative splicing in vertebrates, and are critical ...
  • Guerra Moreno, Ángel; Valcárcel, J. (Juan) (Cold Spring Harbor Laboratory Press (CSHL Press), 2023)
    RNA helicases orchestrate proofreading mechanisms that facilitate accurate intron removal from pre-mRNAs. How these activities are recruited to spliceosome/pre-mRNA complexes remains poorly understood. In this issue of ...
  • Martín García, Elena, 1975-; Vivori, Claudia, 1989-; Rogalska, Malgorzata; Herrero-Vicente, Jorge; Valcárcel, J. (Juan) (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    The regulation of pre-mRNA processing has important consequences for cell division and the control of cancer cell proliferation, but the underlying molecular mechanisms remain poorly understood. We report that three splicing ...
  • Barberán-Soler, Sergio; Fontrodona, Laura; Ribó Rubio, Anna; Lamm, Ayelet T.; Iannone, Camilla, 1984-; Cerón, Julián; Lehner, Ben, 1978-; Valcárcel, J. (Juan) (Cell Press, 2014)
    Many eukaryotic genes contain embedded antisense transcripts and repetitive sequences of unknown function. We report that male germline-specific expression of an antisense transcript contained in an intron of C. elegans ...
  • Hartmann, Britta; Castelo Valdueza, Robert; Miñana Gómez, Belén; Peden, Erin; Blanchette, Marco; Rio, Donald C.; Singh, Ravinder; Valcárcel, J. (Juan) (Cold Spring Harbor Laboratory Press, 2011)
    In Drosophila melanogaster, female-specific expression of Sex-lethal (SXL) and Transformer (TRA) proteins controls sex-specific alternative splicing and/or translation of a handful of regulatory genes responsible for sexual ...
  • Vivori, Claudia, 1989-; Papasaikas, Panagiotis; Stadhouders, Ralph; Di Stefano, Bruno, 1984-; Ribó Rubio, Anna; Berenguer, Clara; Generoso, Serena Francesca, 1988-; Mallol, Anna; Sardina, Jose Luis; Payer, Bernhard; Graf, T. (Thomas); Valcárcel, J. (Juan) (BioMed Central, 2021)
    Background: Somatic cell reprogramming is the process that allows differentiated cells to revert to a pluripotent state. In contrast to the extensively studied rewiring of epigenetic and transcriptional programs required ...
  • Curado, Joao; Iannone, Camilla, 1984-; Tilgner, Hagen, 1980-; Valcárcel, J. (Juan); Guigó Serra, Roderic (BioMed Central, 2016)
    After the publication of this work [1] an error was noticed in Fig. 7. The panel‘h’ is missing from Fig. 7. Please see the corrected figure below. The publisher apologises for this error.
  • Carbonell Núñez, Caterina, 1987-; Ulsamer, Arnau; Vivori, Claudia, 1989-; Papasaikas, Panagiotis; Böttcher, René; Joaquin i Caudet, Manel; Miñana Gómez, Belén; Tejedor Vaquero, Juan Ramón, 1984-; Nadal Clanchet, Eulàlia de; Valcárcel, J. (Juan); Posas Garriga, Francesc (Elsevier, 2019)
    Alternative splicing is a prevalent mechanism of gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps ...
  • Papasaikas, Panagiotis; Tejedor Vaquero, Juan Ramón, 1984-; Vigevani, Luisa, 1985-; Valcárcel, J. (Juan) (Elsevier, 2015)
    Pre-mRNA splicing relies on the poorly understood dynamic interplay between >150 protein components of the spliceosome. The steps at which splicing can be regulated remain largely unknown. We systematically analyzed the ...
  • Tejedor Vaquero, Juan Ramón, 1984-; Papasaikas, Panagiotis; Valcárcel, J. (Juan) (Elsevier, 2015)
    Alternative splicing of Fas/CD95 exon 6 generates either a membrane-bound receptor that promotes, or a soluble isoform that inhibits, apoptosis. Using an automatized genome-wide siRNA screening for alternative splicing ...
  • Horiuchi, Keiko; Papasaikas, Panagiotis; Valcárcel, J. (Juan); Gutiérrez-Adán, Alfonso (Elsevier, 2018)
    The U2AF35-like ZRSR1 has been implicated in the recognition of 3' splice site during spliceosome assembly, but ZRSR1 knockout mice do not show abnormal phenotypes. To analyze ZRSR1 function and its precise role in RNA ...
  • Sebestyén, Endre; Singh, Babita, 1986-; Miñana Gómez, Belén; Pagès Pinós, Amadís; Mateo, Francesc; Pujana, Miguel Angel; Valcárcel, J. (Juan); Eyras Jiménez, Eduardo (Cold Spring Harbor Laboratory Press (CSHL Press), 2016)
    Alternative splicing is regulated by multiple RNA-binding proteins and influences the expression of most eukaryotic genes. However, the role of this process in human disease, and particularly in cancer, is only starting ...
  • Vigevani, Luisa, 1985-; Gohr, André; Webb, Thomas R.; Irimia Martínez, Manuel; Valcárcel, J. (Juan) (Nature Publishing Group, 2017)
    Several splicing-modulating compounds, including Sudemycins and Spliceostatin A, display anti-tumor properties. Combining transcriptome, bioinformatic and mutagenesis analyses, we delineate sequence determinants of the ...
  • Baeza Centurión, Pablo, 1989-; Miñana Gómez, Belén; Valcárcel, J. (Juan); Lehner, Ben, 1978- (eLife, 2020)
    Genetic analyses and systematic mutagenesis have revealed that synonymous, non-synonymous and intronic mutations frequently alter the inclusion levels of alternatively spliced exons, consistent with the concept that altered ...
  • Juan-Mateu, Jonàs; Bajew, Simon, 1994-; Miret-Cuesta, Marta; Íñiguez, Luis P.; Lopez-Pascual, Amaya; Bonnal, Sophie; Atla, Goutham; Bonàs-Guarch, Silvia; Ferrer, Jorge; Valcárcel, J. (Juan); Irimia Martínez, Manuel (Nature Research, 2023)
    Pancreatic islets control glucose homeostasis by the balanced secretion of insulin and other hormones, and their abnormal function causes diabetes or hypoglycaemia. Here we uncover a conserved programme of alternative ...
  • Curado, Joao; Iannone, Camilla, 1984-; Tilgner, Hagen, 1980-; Valcárcel, J. (Juan); Guigó Serra, Roderic (BioMed Central, 2015)
    Background. Pre-mRNA splicing occurs mainly co-transcriptionally, and both nucleosome density and histone modifications have been proposed to play a role in splice site recognition and regulation. However, the extent and ...
  • Bechara, Elias; Sebestyén, Endre; Bernardis, Isabella; Eyras Jiménez, Eduardo; Valcárcel, J. (Juan) (Elsevier, 2013)
    RBM5, a regulator of alternative splicing of apoptotic genes, and its highly homologous RBM6 and RBM10 are RNA-binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically ...
  • Paronetto, Maria Paola; Bernardis, Isabella; Volpe, Elisabetta; Bechara, Elias; Sebestyén, Endre; Eyras Jiménez, Eduardo; Valcárcel, J. (Juan) (Elsevier, 2014)
    The Ewing sarcoma protein EWS is an RNA and DNA binding protein implicated in transcription, pre-mRNA splicing, and DNA damage response. Using CLIP-seq, we identified EWS RNA binding sites in exonic regions near 5′ splice ...
  • Iannone, Camilla, 1984-; Pohl, Andy, 1979-; Papasaikas, Panagiotis; Soronellas, Daniel; Vicent, Guillermo Pablo; Beato, Miguel; Valcárcel, J. (Juan) (Cold Spring Harbor Laboratory Press, 2015)
    Splicing of mRNA precursors can occur cotranscriptionally and it has been proposed that chromatin structure influences splice site recognition and regulation. Here we have systematically explored potential links between ...
  • Gebauer, Fátima; Schwarzl, Thomas; Valcárcel, J. (Juan); Hentze, Matthias W. (Nature Research, 2020)
    RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their malfunction underlies the origin of many diseases. RBPs can recognize hundreds of transcripts and form extensive regulatory networks ...

Search DSpace


Advanced Search

Browse

My Account

In collaboration with Compliant to Partaking