Browsing Center for Genomic Regulation (CRG) by Author "Sadeghi, Iman"

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Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders

Sadeghi, Iman; Gispert López, Juan Domingo; Palumbo, Emilio; Muñoz-Aguirre, Manuel; Wucher, Valentin; D'Argenio, Valeria; Santpere Baró, Gabriel, 1981-; Navarro i Cuartiellas, Arcadi, 1969-; Guigó Serra, Roderic; Vilor Tejedor, Natàlia, 1988- (Elsevier, 2022)

Neurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain abnormalities. Large-scale collaborative efforts have tried to identify the genetic ...
DNA methylation signature as a biomarker of major neuropsychiatric disorders

Shirvani Farsani, Zeinab; Maloum, Zahra; Bagheri Hosseinabadi, Zahra; Vilor Tejedor, Natàlia, 1988-; Sadeghi, Iman; Sadeghi, Iman (Elsevier, 2021)

DNA methylation is a broadly-investigated epigenetic modification that has been considered as a heritable and reversible change. Previous findings have indicated that DNA methylation regulates gene expression in the central ...
Single-cell transcriptional changes in neurodegenerative diseases

Ahmadi, Amirhossein; Gispert López, Juan Domingo; Navarro i Cuartiellas, Arcadi, 1969-; Vilor Tejedor, Natàlia, 1988-; Sadeghi, Iman (Elsevier, 2021)

In recent decades, our understanding of the molecular changes involved in neurodegenerative diseases has been transformed. Single-cell RNA sequencing and single-nucleus RNA sequencing technologies have been applied to ...

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