Browsing Center for Genomic Regulation (CRG) by Author "Sabeti, Pardis C."

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Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques

Santus, Luisa; Sopena Rios, Maria; García Pérez, Raquel, 1989-; Lin, Aaron E.; Adams, Gordon C.; Barnes, Kayla G.; Siddle, Katherine J.; Wohl, Shirlee; Reverter, Ferran; Rinn, John L.; Bennett, Richard S.; Hensley, Lisa E.; Sabeti, Pardis C.; Melé Messeguer, Marta, 1982- (Nature Research, 2023)

Long non-coding RNAs (lncRNAs) are involved in numerous biological processes and are pivotal mediators of the immune response, yet little is known about their properties at the single-cell level. Here, we generate a ...
The functional and evolutionary impacts of human-specific deletions in conserved elements

Xue, James R.; Mackay-Smith, Ava; Mouri, Kousuke; Fernandez Garcia, Meilin; Dong, Michael X.; Akers, Jared F.; Noble, Mark; Li, Xue; Zoonomia Consortium; Lindblad-Toh, Kerstin; Karlsson, Elinor K.; Noonan, James P.; Capellini, Terence D.; Brennand, Kristen J.; Tewhey, Ryan; Sabeti, Pardis C.; Reilly, Steven K. (American Association for the Advancement of Science (AAAS), 2023)

Conserved genomic sequences disrupted in humans may underlie uniquely human phenotypic traits. We identified and characterized 10,032 human-specific conserved deletions (hCONDELs). These short (average 2.56 base pairs) ...

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