Browsing Center for Genomic Regulation (CRG) by Author "O'Connell, Mary J."

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Gene fusions derived by transcriptional readthrough are driven by segmental duplication in human

McCartney, Ann M.; Hyland, Edel M.; Cormican, Paul; Moran, Raymond J.; Webb, Andrew E.; Lee, Kate D.; Hernández Rodríguez, Jéssica, 1983-; Prado Martínez, Javier, 1987-; Creevey, Christopher J.; Aspden, Julie L.; McInerney, James O.; Marquès i Bonet, Tomàs, 1975-; O'Connell, Mary J. (Oxford University Press, 2019)

Gene fusion occurs when two or more individual genes with independent open reading frames becoming juxtaposed under the same open reading frame creating a new fused gene. A small number of gene fusions described in detail ...
Return to the sea, get huge, beat cancer: an analysis of cetacean genomes including an asssembly for the humpback whale (megaptera novaeangliae)

Tollis, Marc; Robbins, Jooke; Webb, Andrew E.; Kuderna, Lukas, 1989-; Caulin, Aleah F.; Garcia, Jacinda D.; Bèrubè, Martine; Pourmand, Nader; Marquès i Bonet, Tomàs, 1975-; O'Connell, Mary J.; Palsbøll, Per J.; Maley, Carlo C. (Oxford University Press, 2019)

Cetaceans are a clade of highly specialized aquatic mammals that include the largest animals that have ever lived. The largest whales can have ∼1,000× more cells than a human, with long lifespans, leaving them theoretically ...

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