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Browsing Center for Genomic Regulation (CRG) by Author "Mocavini, Ivano"

Browsing Center for Genomic Regulation (CRG) by Author "Mocavini, Ivano"

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  • Chammas, Paul, 1992-; Mocavini, Ivano; Di Croce, Luciano (Nature Research, 2020)
    Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex involved in the regulation of gene expression in metazoans. PRC2 is formed by a tetrameric core that endows the complex with histone methyltransferase ...
  • Mocavini, Ivano; Pippa, Simone; Licursi, Valerio; Paci, Paola; Trisciuoglio, Daniela; Mannironi, Cecilia; Presutti, Carlo; Negri, Rodolfo (Wiley Open Access, 2019)
    JARID1B/KDM5B histone demethylase's mRNA is markedly overexpressed in breast cancer tissues and cell lines and the protein has been shown to have a prominent role in cancer cell proliferation and DNA repair. However, the ...
  • Di Carlo, Valerio; Mocavini, Ivano; Di Croce, Luciano (Rockefeller University Press, 2019)
    Epigenetic mechanisms are crucial for sustaining cell type-specific transcription programs. Among the distinct factors, Polycomb group (PcG) proteins are major negative regulators of gene expression in mammals. These ...

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