Browsing Center for Genomic Regulation (CRG) by Author "Kagerbauer, Birgit"

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Evidence for the biogenesis of more than 1,000 novel human microRNAs

Friedländer, Marc R.; Lizano González, Esther, 1974-; Houben, Anna J.; Bezdan, Daniela; Bañez Coronel, Mónica; Kudla, Grzegorz; Mateu Huertas, Elisabet, 1983-; Kagerbauer, Birgit; González Morilla, Justo; Chen, Kevin C; LeProust, Emily M; Martí Puig, Eulàlia; Estivill, Xavier, 1955- (BioMed Central, 2014)

Background: MicroRNAs (miRNAs) are established regulators of development, cell identity and disease. Although nearly two thousand human miRNA genes are known and new ones are continuously discovered, no attempt has been ...
Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.

Rué, Laura; Bañez Coronel, Mónica; Creus-Muncunill, Jordi; Giralt, Albert; Alcalá-Vida, Rafael; Mentxaka, Gartze; Kagerbauer, Birgit; Zomeño-Abellán, M. Teresa; Aranda, Zeus; Venturi, Veronica; Pérez-Navarro, Esther; Estivill, Xavier, 1955-; Martí, Eulàlia (American Society for Clinical Investigation, 2016)

Huntington's disease (HD) is a polyglutamine disorder caused by a CAG expansion in the Huntingtin (HTT) gene exon 1. This expansion encodes a mutant protein whose abnormal function is traditionally associated with HD ...

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