Browsing Center for Genomic Regulation (CRG) by Author "Babu, M. Madan"

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Conditional epistatic interaction maps reveal global functional rewiring of genome integrity pathways in escherichia coli

Kumar, Ashwani; Beloglazova, Natalia; Bundalovic-Torma, Cedoljub; Phanse, Sadhna; Deineko, Viktor; Gagarinova, Alla; Musso, Gabriel; Vlasblom, James; Lemak, Sofia; Hooshyar, Mohsen; Minic, Zoran; Wagih, Omar; Mosca, Roberto; Aloy, Patrick, 1972-; Golshani, Ashkan; Parkinson, John; Emili, Andrew; Yakunin, Alexander F.; Babu, M. Madan (Elsevier, 2016)

As antibiotic resistance is increasingly becoming a public health concern, an improved understanding of the bacterial DNA damage response (DDR), which is commonly targeted by antibiotics, could be of tremendous therapeutic ...
The fitness cost and benefit of phase-separated protein deposits

Sanchez de Groot, Natalia; Torrent, Marc; Ravarani, Charles N.J.; Trusina, Ala; Ventura, Salvador; Babu, M. Madan (Wiley-VCH Verlag, 2019)

Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane-less compartments for many cellular processes. What are the fitness ...

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