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Biomechanical wall properties of human intracranial aneurysms resected following surgical clipping (IRRAs Project)

Mostra el registre parcial de l'element Costalat, V. Sánchez, M. Ambard, D. Thines, L. Lonjon, N. Nicoud, F. Brunel, H. Lejeune, J. P. Dufour, H. Bouillot, P. Lhaldky, J. P. Kouri, K. Segnarbieux, F. Mourage, C. A. Lobostein, K. Villa-Uriol, Maria-Cruz Zhang, Chong Frangi Caregnato, Alejandro Mercier, G. Bonafé, A. Sarry, L. Jourdan, F.
dc.contributor.other Universitat Pompeu Fabra 2012-07-09T09:58:47Z 2012-07-09T09:58:47Z 2011
dc.identifier.citation Costalat V, Sanchez M, Ambard D, Thines L, Lonjon N, Nicoud F, Brunel H, Lejeune JP, Dufour H, Bouillot P, Lhaldky J P, Kouri K, Segnarbieux F, Mourage CA, Lobostein K, Villa-Uriol MC, Zhang C, Frangi AF, Mercier G, Bonafé A, Sarry L, Jourdan F. Biomechanical wall properties of human intracranial aneurysms resected following surgical clipping (IRRAs Project). J Biomech. 2011; 44(15): 2685-2691. DOI: 10.1016/j.jbiomech.2011.07.026
dc.identifier.issn 0021-9290
dc.description.abstract Background and purpose: Individual rupture risk assessment of intracranial aneurysms is a major issue in the clinical management of asymptomatic aneurysms. Aneurysm rupture occurs when wall tension exceeds the strength limit of the wall tissue. At present, aneurysmal wall mechanics are poorly understood and thus, risk assessment involving mechanical properties is inexistent. Aneurysm computational hemodynamics studies make the assumption of rigid walls, an arguable simplification. We therefore aim to assess mechanical properties of ruptured and unruptured intracranial aneurysms in order to provide the foundation for future patient-specific aneurysmal risk assessment. This work also challenges some of the currently held hypotheses in computational flow hemodynamics research. Methods: A specific conservation protocol was applied to aneurysmal tissues following clipping and resection in order to preserve their mechanical properties. Sixteen intracranial aneurysms (11 female, 5 male) underwent mechanical uniaxial stress tests under physiological conditions, temperature, and saline isotonic solution. These represented 11 unruptured and 5 ruptured aneurysms. Stress/strain curves were then obtained for each sample, and a fitting algorithm was applied following a 3-parameter (C(10), C(01), C(11)) Mooney-Rivlin hyperelastic model. Each aneurysm was classified according to its biomechanical properties and (un)rupture status./nResults: Tissue testing demonstrated three main tissue classes: Soft, Rigid, and Intermediate. All unruptured aneurysms presented a more Rigid tissue than ruptured or pre-ruptured aneurysms within each gender subgroup. Wall thickness was not correlated to aneurysmal status (ruptured/unruptured). An Intermediate subgroup of unruptured aneurysms with softer tissue characteristic was identified and correlated with multiple documented risk factors of rupture. Conclusion: There is a significant modification in biomechanical properties between ruptured aneurysm, presenting a soft tissue and unruptured aneurysms, presenting a rigid material. This finding strongly supports the idea that a biomechanical risk factor based assessment should be utilized in the to improve the therapeutic decision making.
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Journal of Biomechanics. 2011; 44(15): 2685-2691
dc.rights (c) Elsevier (
dc.subject.other Aneurismes cerebrals
dc.subject.other Hemodinàmica
dc.title Biomechanical wall properties of human intracranial aneurysms resected following surgical clipping (IRRAs Project)
dc.type info:eu-repo/semantics/article
dc.subject.keyword Intracranial aneurysm
dc.subject.keyword Soft tissue
dc.subject.keyword Hyperelastic material
dc.subject.keyword Rupture risk
dc.subject.keyword Human specimen
dc.subject.keyword Uniaxial traction test
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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