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K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons

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dc.contributor.author Chow, Alan
dc.contributor.author Erisir, A.
dc.contributor.author Farb, C.
dc.contributor.author Nadal, M. S.
dc.contributor.author Ozaita Mintegui, Andrés, 1969-
dc.contributor.author Lau, David
dc.contributor.author Welker, E.
dc.contributor.author Rudy, Bernardo
dc.date.accessioned 2012-07-05T06:54:24Z
dc.date.available 2012-07-05T06:54:24Z
dc.date.issued 1999
dc.identifier.citation Chow A, Erisir A, Farb C, Nadal MS, Ozaita A, Lau D, Welker E, Rudy B. K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons. J Neurosci. 1999; 19(21): 9332-45. DOI 10.1523/jneurosci.19-21-09332.1999
dc.identifier.issn 0270-6474
dc.identifier.uri http://hdl.handle.net/10230/16673
dc.description.abstract Kv3.1 and Kv3.2 K+ channel proteins form similar voltage-gated K+ channels with unusual properties, including fast activation at voltages positive to −10 mV and very fast deactivation rates. These properties are thought to facilitate sustained high-frequency firing. Kv3.1 subunits are specifically found in fast-spiking, parvalbumin (PV)-containing cortical interneurons, and recent studies have provided support for a crucial role in the generation of the fast-spiking phenotype. Kv3.2 mRNAs are also found in a small subset of neocortical neurons, although the distribution of these neurons is different. We raised antibodies directed against Kv3.2 proteins and used dual-labeling methods to identify the neocortical neurons expressing Kv3.2 proteins and to determine their subcellular localization. Kv3.2 proteins are prominently expressed in patches in somatic and proximal dendritic membrane as well as in axons and presynaptic terminals of GABAergic interneurons. Kv3.2 subunits are found in all PV-containing neurons in deep cortical layers where they probably form heteromultimeric channels with Kv3.1 subunits. In contrast, in superficial layer PV-positive neurons Kv3.2 immunoreactivity is low, but Kv3.1 is still prominently expressed. Because Kv3.1 and Kv3.2 channels are differentially modulated by protein kinases, these results raise the possibility that the fast-spiking properties of superficial- and deep-layer PV neurons are differentially regulated by neuromodulators. Interestingly, Kv3.2 but not Kv3.1 proteins are also prominent in a subset of seemingly non-fast-spiking, somatostatin- and calbindin-containing interneurons, suggesting that the Kv3.1–Kv3.2 current type can have functions other than facilitating high-frequency firing.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Society for Neuroscience
dc.relation.ispartof J Neurosci. 1999; 19(21): 9332-45
dc.rights (c) 1999, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/19/21/9332
dc.subject.other Xarxes neuronals (Neurobiologia)
dc.subject.other Neurones -- Fisiologia
dc.title K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1523/jneurosci.19-21-09332.1999
dc.subject.keyword Voltage-gated K1 channels
dc.subject.keyword Kv3 subunits
dc.subject.keyword Fast spiking
dc.subject.keyword Inhibition
dc.subject.keyword GABA
dc.subject.keyword High-frequency firing
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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