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dc.contributor.author | Valverde Granados, Olga |
dc.contributor.author | Maldonado, Rafael, 1961- |
dc.contributor.author | Valjent, Emmanuel |
dc.contributor.author | Zimmer, Anne M. |
dc.contributor.author | Zimmer, Andreas |
dc.date.accessioned | 2012-07-05T06:54:19Z |
dc.date.available | 2012-07-05T06:54:19Z |
dc.date.issued | 2000 |
dc.identifier.citation | Valverde O, Maldonado R, Valjent E, Zimmer AM, Zimmer A. Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice. J Neurosci. 2000;20(24):9284-9. DOI: 10.1523/jneurosci.20-24-09284.2000 |
dc.identifier.issn | 0270-6474 |
dc.identifier.uri | http://hdl.handle.net/10230/16670 |
dc.description.abstract | The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol was reduced in mutant mice, whereas no difference between genotypes was observed in the effects induced on body temperature, locomotion, or ring catalepsy. During a chronic treatment with Delta9-tetrahydrocannabinol, the development of tolerance to the analgesic responses induced by this compound was slower in mice lacking enkephalin. In addition, cannabinoid withdrawal syndrome, precipitated in Delta9-tetrahydrocannabinol-dependent mice by the injection of SR141716A, was significantly attenuated in mutant mice. These results indicate that the endogenous enkephalinergic system is involved in the antinociceptive responses of Delta9-tetrahydrocannabinol and participates in the expression of cannabinoid abstinence. |
dc.description.sponsorship | This work was supported by European Commission Grant BIOM ED-2/98–2227 and Fondo de Investigaciones Sanitaria Grant 99/0624 (R.M.), Dr. Esteve S.A. Laboratories, and La Fondation des Treilles, and by a grant from the Land Nordrhein-Westfalen (Innovationsprogramm Forschung) (A.Z.). |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Society for Neuroscience |
dc.relation.ispartof | Journal of Neuroscience. 2000;20(24):9284-9 |
dc.rights | © 2000, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/20/24/9284 |
dc.subject.other | Cannabinoides -- Efectes fisiològics |
dc.subject.other | Cannabinoides -- Receptors |
dc.subject.other | Drogoaddicció -- Aspectes moleculars |
dc.title | Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1523/jneurosci.20-24-09284.2000 |
dc.subject.keyword | Cannabinoid |
dc.subject.keyword | Opioid |
dc.subject.keyword | Mice |
dc.subject.keyword | Mutation |
dc.subject.keyword | Withdrawal |
dc.subject.keyword | Addiction |
dc.subject.keyword | Tolerance |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |