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Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice

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dc.contributor.author Berrendero Díaz, Fernando, 1971-
dc.contributor.author Kieffer, Brigitte L.
dc.contributor.author Maldonado, Rafael, 1961-
dc.date.accessioned 2012-07-05T06:53:53Z
dc.date.available 2012-07-05T06:53:53Z
dc.date.issued 2002
dc.identifier.citation Berrendero, F.; Kieffer, B.L.; Maldonado, R. Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice. J. Neurosci. 2002; 22(24): 10935-40. DOI: 10.1523/JNEUROSCI.22-24-10935.2002
dc.identifier.issn 0270-6474
dc.identifier.uri http://hdl.handle.net/10230/16664
dc.description.abstract The involvement of μ-opioid receptors in different behavioral responses elicited by nicotine was explored by using μ-opioid receptor knock-out mice. The acute antinociceptive responses induced by nicotine in the tail-immersion and hot-plate tests were reduced in the mutant mice, whereas no difference between genotypes was observed in the locomotor responses. The rewarding effects induced by nicotine were then investigated using the conditioning place-preference paradigm. Nicotine produced rewarding responses in wild-type mice but failed to produce place preference in knock-out mice, indicating the inability of this drug to induce rewarding effects in the absence of μ-opioid receptors. Finally, the somatic expression of the nicotine withdrawal syndrome, precipitated in dependent mice by the injection of mecamylamine, was evaluated. Nicotine withdrawal was significantly attenuated in knock-out mutants when compared with wild-type mice. In summary, the present results show that μ-opioid receptors are involved in the rewarding responses induced by nicotine and participate in its antinociceptive responses and the expression of nicotine physical dependence.
dc.description.sponsorship This work has been supported by grants from Plan Nacional Sobre Drogas, European Communities BIOM ED2 (98-2227), Human Frontier Science Program Organization (RG0077/2000-B), Generalitat de Catalunya (Research Distinction), and Laboratorios Dr. Esteve
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Society for Neuroscience
dc.relation.ispartof J. Neurosci. 2002; 22(24): 10935-40
dc.rights © 2002, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/22/24/10935
dc.subject.other Nicotina -- Addicció
dc.subject.other Nicotina -- Efectes fisiològics
dc.subject.other Receptors nicotínics
dc.title Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1523/JNEUROSCI.22-24-10935.2002
dc.subject.keyword Nicotine
dc.subject.keyword Opioid
dc.subject.keyword Knock-out mice
dc.subject.keyword Withdrawal
dc.subject.keyword Conditioning place preference
dc.subject.keyword Reward
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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