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Genetic characterization of the ABO blood group in Neandertals

Mostra el registre parcial de l'element Lalueza Fox, Carles, 1965- Gigli, Elena, 1978- Rasilla Vives, Marco de la Fortea, Javier Rosas, Antonio Bertranpetit, Jaume, 1952- Krause, Johannes 2012-05-03T08:26:02Z 2012-05-03T08:26:02Z 2008
dc.identifier.citation Lalueza-Fox C, Gigli E, Rasilla M, Fortea J, Rosas A, Bertranpetit J, Krause J. Genetic characterization of the ABO blood group in Neandertals. BMC Evol. Biol. 2008; 8: 342. DOI 10.1186/1471-2148-8-342
dc.identifier.issn 1471-2148
dc.description.abstract Background: The high polymorphism rate in the human ABO blood group gene seems to be related to susceptibility to different pathogens. It has been estimated that all genetic variation underlying the human ABO alleles appeared along the human lineage, after the divergence from the chimpanzee lineage. A paleogenetic analysis of the ABO blood group gene in Neandertals allows us to directly test for the presence of the ABO alleles in these extinct humans. Results: We have analysed two male Neandertals that were retrieved under controlled conditions at the El Sidron site in Asturias (Spain) and that appeared to be almost free of modern human DNA contamination. We find a human specific diagnostic deletion for blood group O (O01 haplotype) in both Neandertal individuals. Conclusion: These results suggest that the genetic change responsible for the O blood group in humans predates the human and Neandertal divergence. A potential selective event associated with the emergence of the O allele may have therefore occurred after humans separated from their common ancestor with chimpanzees and before the human-Neandertal population divergence.
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof BMC Evol. Biol. 2008; 8: 342
dc.rights (c) 2008 Lalueza-Fox et al. Creative Commons Attribution License
dc.subject.other Neandertals -- Genètica
dc.subject.other Genètica evolutiva
dc.subject.other ADN mitocondrial -- Genètica
dc.title Genetic characterization of the ABO blood group in Neandertals
dc.type info:eu-repo/semantics/article
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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