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dc.contributor.author | López Muñoz, Laura |
dc.contributor.author | Pastor Maeso, Manuel |
dc.contributor.author | Sanz, Ferran |
dc.contributor.author | Selent, Jana |
dc.date.accessioned | 2011-07-27T08:27:56Z |
dc.date.available | 2011-07-27T08:27:56Z |
dc.date.issued | 2008 |
dc.identifier.citation | Selent J, López L, Sanz F, Pastor M. Multi-Receptor Binding Profile of Clozapine and Olanzapine: A Structural Study Based on the New β2 Adrenergic Receptor Template. ChemMedChem. 2008;3(8):1194-8. DOI: 10.1002/cmdc.200800074 |
dc.identifier.issn | 1860-7179 |
dc.identifier.uri | http://hdl.handle.net/10230/12425 |
dc.description.abstract | Schizophrenia is a devastating mental disorder that has a large/nimpact on the quality of life for those who are afflicted and is/nvery costly for families and society.[1] Although the etiology of/nschizophrenia is still unknown and no cure has yet been/nfound, it is treatable, and pharmacological therapy often produces/nsatisfactory results. Among the various antipsychotic/ndrugs in use, clozapine is widely recognized as one ofthe/nmost clinically effective agents, even if it elicits significant side/neffects such as metabolic disorders and agranulocytosis. Clozapine/nand the closely related compound olanzapine are good/nexamples ofdrug s with a complex multi-receptor profile ;[2]/nthey have affinities toward serotonin, dopamine, a adrenergic,/nmuscarinic, and histamine receptors, among others. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Wiley-Blackwell |
dc.relation.ispartof | ChemMedChem. 2008;3(8):1194-8 |
dc.rights | © 2008 Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim |
dc.subject.other | Serotonina |
dc.subject.other | Esquizofrènia -- Quimioteràpia |
dc.subject.other | Esquizofrènia |
dc.title | Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta (2) adrenergic receptor template |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1002/cmdc.200800074 |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |