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Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta (2) adrenergic receptor template

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dc.contributor.author López Muñoz, Laura
dc.contributor.author Pastor Maeso, Manuel
dc.contributor.author Sanz, Ferran
dc.contributor.author Selent, Jana
dc.date.accessioned 2011-07-27T08:27:56Z
dc.date.available 2011-07-27T08:27:56Z
dc.date.issued 2008
dc.identifier.citation Selent J, López L, Sanz F, Pastor M. Multi-Receptor Binding Profile of Clozapine and Olanzapine: A Structural Study Based on the New β2 Adrenergic Receptor Template. ChemMedChem. 2008; 3(8): 1194-8. DOI 10.1002/cmdc.200800074
dc.identifier.issn 1860-7179
dc.identifier.uri http://hdl.handle.net/10230/12425
dc.description.abstract Schizophrenia is a devastating mental disorder that has a large/nimpact on the quality of life for those who are afflicted and is/nvery costly for families and society.[1] Although the etiology of/nschizophrenia is still unknown and no cure has yet been/nfound, it is treatable, and pharmacological therapy often produces/nsatisfactory results. Among the various antipsychotic/ndrugs in use, clozapine is widely recognized as one ofthe/nmost clinically effective agents, even if it elicits significant side/neffects such as metabolic disorders and agranulocytosis. Clozapine/nand the closely related compound olanzapine are good/nexamples ofdrug s with a complex multi-receptor profile ;[2]/nthey have affinities toward serotonin, dopamine, a adrenergic,/nmuscarinic, and histamine receptors, among others.
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof ChemMedChem. 2008; 3(8): 1194-8
dc.rights © 2008 Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim
dc.subject.other Serotonina
dc.subject.other Esquizofrènia -- Quimioteràpia
dc.subject.other Esquizofrènia
dc.title Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta (2) adrenergic receptor template
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/cmdc.200800074
dc.rights.accessRights info:eu-repo/semantics/OpenAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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