Articles (Hospital del Mar Research Institute)
http://hdl.handle.net/10230/23132
2024-03-19T09:45:57ZOne abnormal value or vomiting after oral glucose tolerance test in pregnancy: incidence and impact on maternal-fetal outcomes
http://hdl.handle.net/10230/59481
One abnormal value or vomiting after oral glucose tolerance test in pregnancy: incidence and impact on maternal-fetal outcomes
Benaiges Foix, David
2023-01-01T00:00:00ZRisk of suicide attempt repetition after an index attempt: A systematic review and meta-analysis
http://hdl.handle.net/10230/59480
Risk of suicide attempt repetition after an index attempt: A systematic review and meta-analysis
Pérez Solá, Victor
2023-01-01T00:00:00ZA longitudinal investigation of non-suicidal self-injury persistence patterns, risk factors, and clinical outcomes during the college period
http://hdl.handle.net/10230/59453
A longitudinal investigation of non-suicidal self-injury persistence patterns, risk factors, and clinical outcomes during the college period
Kiekens, Glenn; Claes, Laurence; Hasking, Penelope; Mortier, Philippe; Bootsma, Erik; Boyes, Mark; Myin-Germeys, Inez; Demyttenaere, Koen; Cuijpers, Pim; Kessler, Ronald C.; Nock, Matthew K.; Bruffaerts, Ronny
Abstract
Background: Although non-suicidal self-injury (NSSI) is known typically to begin in adolescence, longitudinal information is lacking about patterns, predictors, and clinical outcomes of NSSI persistence among emerging adults. The present study was designed to (1) estimate NSSI persistence during the college period, (2) identify risk factors and high-risk students for NSSI persistence patterns, and (3) evaluate the association with future mental disorders and suicidal thoughts and behaviors (STB).
Methods: Using prospective cohorts from the Leuven College Surveys (n = 5915), part of the World Mental Health International College Student Initiative, web-based surveys assessed mental health and psychosocial problems at college entrance and three annual follow-up assessments.
Results: Approximately one in five (20.4%) students reported lifetime NSSI at college entrance. NSSI persistence was estimated at 56.4%, with 15.6% reporting a high-frequency repetitive pattern (≥five times yearly). Many hypothesized risk factors were associated with repetitive NSSI persistence, with the most potent effects observed for pre-college NSSI characteristics. Multivariate models suggest that an intervention focusing on the 10-20% at the highest predicted risk could effectively reach 34.9-56.7% of students with high-frequency repetitive NSSI persistence (PPV = 81.8-93.4, AUC = 0.88-0.91). Repetitive NSSI persistence during the first two college years predicted 12-month mental disorders, role impairment, and STB during the third college year, including suicide attempts.
Conclusions: Most emerging adults with a history of NSSI report persistent self-injury during their college years. Web-based screening may be a promising approach for detecting students at risk for a highly persistent NSSI pattern characterized by subsequent adverse outcomes.
Keywords: College period; emerging adulthood; mental disorders; non-suicidal self-injury; persistence; suicidal thoughts and behaviors.
2023-01-01T00:00:00ZClinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts
http://hdl.handle.net/10230/59452
Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts
Lantero Rodríguez, Juan; Vrillon, Agathe; Fernández-Lebrero, Aida; Ortiz Romero, Paula; Snellman, Anniina; Montoliu-Gaya, Laia; Brum, Wagner S.; Cognat, Emmanuel; Dumurgier, Julien; Puig-Pijoan, Albert; Navalpotro-Gómez, Irene; García-Escobar, Greta; Karikari, Thomas K.; Vanmechelen, Eugeen; Ashton, Nicholas J.; Zetterberg, Henrik; Suárez-Calvet, Marc; Paquet, Claire; Blennow, Kaj
Background
Cerebrospinal fluid (CSF) p-tau235 is a novel biomarker highly specific of Alzheimer’s disease (AD). However, CSF p-tau235 has only been studied in well-characterized research cohorts, which do not fully reflect the patient landscape found in clinical settings. Therefore, in this multicentre study, we investigated the performance of CSF p-tau235 to detect symptomatic AD in clinical settings and compared it with CSF p-tau181, p-tau217 and p-tau231.
Methods
CSF p-tau235 was measured using an in-house single molecule array (Simoa) assay in two independent memory clinic cohorts: Paris cohort (Lariboisière Fernand-Widal University Hospital Paris, France; n=212) and BIODEGMAR cohort (Hospital del Mar, Barcelona, Spain; n=175). Patients were classified by the syndromic diagnosis (cognitively unimpaired [CU], mild cognitive impairment [MCI] or dementia) and their biological diagnosis (amyloid-beta [Aβ]+ or Aβ
). Both cohorts included detailed cognitive assessments and CSF biomarker measurements (clinically validated core AD biomarkers [Lumipulse CSF Aβ1–42/40 ratio, p-tau181 and t-tau] and in-house developed Simoa CSF p-tau181, p-tau217 and p-tau231).
Results
High CSF p-tau235 levels were strongly associated with CSF amyloidosis regardless of the clinical diagnosis, being significantly increased in MCI Aβ+ and dementia Aβ+ when compared with all other Aβ− groups (Paris cohort: P ˂0.0001 for all; BIODEGMAR cohort: P ˂0.05 for all). CSF p-tau235 was pronouncedly increased in the A+T+ profile group compared with A−T− and A+T− groups (P ˂0.0001 for all). Moreover, CSF p-tau235 demonstrated high diagnostic accuracies identifying CSF amyloidosis in symptomatic cases (AUCs=0.86 to 0.96) and discriminating AT groups (AUCs=0.79 to 0.98). Overall, CSF p-tau235 showed similar performances to CSF p-tau181 and CSF p-tau231 when discriminating CSF amyloidosis in various scenarios, but lower than CSF p-tau217. Finally, CSF p-tau235 associated with global cognition and memory domain in both cohorts.
Conclusions
CSF p-tau235 was increased with the presence of CSF amyloidosis in two independent memory clinic cohorts. CSF p-tau235 accurately identified AD in both MCI and dementia patients. Overall, the diagnostic performance of CSF p-tau235 was comparable to that of other CSF p-tau measurements, indicating its suitability to support a biomarker-based AD diagnosis in clinical settings.
2023-01-01T00:00:00Z