Osteoarthritis is the most common musculoskeletal disease worldwide, often characterized by degradation of the articular cartilage, chronic joint pain and disability. Cognitive dysfunction, anxiety and depression are common ...
Bura, S. Andreea, 1978-; Guegan, Thomas, 1983-; Zamamillo Castanedo, Daniel; Vela Hernández, José Miguel; Maldonado, Rafael, 1961-(Wiley-Blackwell, 2013)
BACKGROUND: The treatment of neuropathic pain is unsatisfactory at the present moment and the sigma 1 receptor has been identified as a new potential target for neuropathic pain. The aim of this study was to use an operant ...
In the present thesis, and in the context of the Sigma-1 receptor (σ1R) research project running at the pharmaceutical company ESTEVE, we addressed, at the preclinical level, the role played by selective σ1R antagonism/blockade ...
