Visualitza per autor "Valverde Granados, Olga"

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  • Zimmer, Andreas; Valjent, Emmanuel; König, Monika; Zimmer, Anne M.; Robledo, Patrícia, 1958-; Hahn, Heidi; Valverde Granados, Olga; Maldonado, Rafael, 1961- (Society for Neuroscience, 2001)
    The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show ...
  • Matthes, Hans W. D.; Smadja, C.; Valverde Granados, Olga; Vonesch, J. L.; Foutz, A. S.; Boudinot, E.; Denavit-Saubié, M.; Severini, Cintia; Negri, Lucia; Roques, Bernard P.; Maldonado, Rafael, 1961-; Kieffer, Brigitte L. (Society for Neuroscience, 1998)
    Previous pharmacological studies have indicated the possible existence of functional interactions between μ-, δ- and κ-opioid receptors in the CNS. We have investigated this issue using a genetic approach. Here we describe ...
  • Aso Pérez, Ester; Valverde Granados, Olga; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Pazos, Ángel; Ledent, Catherine; Valdizán, Elsa M. (Wiley-Blackwell, 2008)
    Stress can cause damage and atrophy of neurons in the hippocampus by deregulating the expression of neurotrophic factors that promote neuronal plasticity. The endocannabinoid system represents a physiological substrate ...
  • Navarro Zaragoza, Javier; Ros Simó, Clara; Milanés, María Victoria; Valverde Granados, Olga; Laorden, María Luisa (Public Library of Science (PLoS), 2015)
    Binge drinking is a common pattern of ethanol consumption among young people. Binge drinkers are especially susceptible to brain damage when other substances are co-administered, in particular 3,4 methylendioxymethamphetamine ...
  • Valverde Granados, Olga; Maldonado, Rafael, 1961-; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas (Society for Neuroscience, 2000)
    The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol ...
  • Touriño Raposo, Clara; Ledent, Catherine; Maldonado, Rafael, 1961-; Valverde Granados, Olga (Elsevier, 2008)
    Background: 3, 4-methylenedioxymethamphetamine (MDMA) is a popular recreational drug widely abused by young people. The endocannabinoid system is involved in the addictive processes induced by different drugs of abuse. ...
  • Aso Pérez, Ester; Pazos, Ángel; Mato, Susana; Maldonado, Rafael, 1961-; Valverde Granados, Olga; Martín, Miguel; Castro, Elena (Wiley-Blackwell, 2007)
    Interaction between brain endocannabinoid (EC) and serotonin (5-HT) systems was investigated by examining 5-HT-dependent behavioural and biochemical responses in CB1 receptor knockout mice. CB1 knockout animals exhibited ...
  • Ros i Simó, Clara, 1984- (Universitat Pompeu Fabra, 2013-03-15)
    Adolescence is a critical developmental period in which the brain emerges from an immature state to adulthood. This process of brain development is associated to greater cognitive capacity but also to altered emotional ...
  • Aso Pérez, Ester; Renoir, Thibault; Valverde Granados, Olga; Lanfumey, Laurence; Maldonado, Rafael, 1961-; Hamon, Michel; Ledent, Catherine; Mengod, Guadalupe (Wiley-Blackwell, 2009)
    Serotonergic and endocannabinoid systems are important substrates for the control of emotional behavior and growing evidence show an involvement in the pathophysiology of mood disorders. In the present study, the absence ...
  • Gracia Rubio, Irene, 1986-; Martinez-Laorden, Elena; Moscoso Castro, Maria, 1988-; Milanés, María Victoria; Laorden, María Luisa; Valverde Granados, Olga (Public Library of Science (PLoS), 2016)
    Adverse early-life conditions induce persistent disturbances that give rise to negative emotional states. Therefore, early life stress confers increased vulnerability to substance use disorders, mainly during adolescence ...
  • Touriño Raposo, Clara; Maldonado, Rafael, 1961-; Valverde Granados, Olga (Springer, 2007)
    3, 4-Methylenedioxymethamphetamine (MDMA) and cannabis are widely abused illicit drugs that are frequently consumed in combination. Interactions between these two drugs have been reported in several pharmacological responses ...
  • Gracia Rubio, Irene, 1986- (Universitat Pompeu Fabra, 2016-03-15)
    Early life experiences play a key role in brain function and behaviour. Maternal separation produced negative early life experiences that induce emotional alterations. Contrary, the communal nest has been proposed as a ...
  • Aso Pérez, Ester (Universitat Pompeu Fabra, 2008-12-19)
    Los trastornos emocionales de tipo depresivo y la ansiedad son las formas más prevalentes de enfermedad mental y suponen un serio problema de salud en la sociedad occidental. Recientemente, se ha postulado que el sistema ...
  • Castañé Forn, Anna (Universitat Pompeu Fabra, 2005-06-16)
    Con la finalidad de explorar con profundidad las bases neurobiológicas de la adicción a cannabinoides hemos llevado a cabo diferentes estudios farmacológicos y moleculares. El sustrato neuroanatómico de la dependencia ...
  • Gutiérrez Sacristán, Alba; Grosdidier, Solène; Valverde Granados, Olga; Torrens, Marta; Bravo Serrano, Àlex, 1984-; Piñero González, Janet, 1977-; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2015)
    PsyGeNET (Psychiatric disorders and Genes association NETwork) is a knowledge platform for the exploratory analysis of psychiatric diseases and their associated genes. PsyGeNET is composed of a database and a web interface ...
  • Johansson, Emily M.; García-Gutiérrez, María S.; Moscoso Castro,Maria, 1988-; Manzanares, Jorge; Valverde Granados, Olga (Public Library of Science, 2015)
    The recreational drugs, alcohol and 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") have both been shown to cause immune activation in vivo, and they are linked to cognitive impairment and anxiety-like behaviors in ...
  • Soria Rodríguez, Guadalupe (Universitat Pompeu Fabra, 2006-06-21)
    La adicción es un trastorno crónico de la conducta caracterizado por la búsqueda y el consumo compulsivos de la droga, la pérdida de control para limitar dicho consumo, a aparición de un estado emocional negativo cuando ...
  • Touriño Raposo, Clara (Universitat Pompeu Fabra, 2009-02-17)
    La 3,4-metilendioximetamfetamina (MDMA, èxtasi) i el cannabis són dues drogues les quals es consumeixen conjuntament de manera habitual. Malgrat que tots dos compostos presenten propietats reforçant i potencial addictiu, ...
  • Touriño Raposo, Clara; Zimmer, Andreas; Valverde Granados, Olga (Public Library of Science (PLoS), 2010)
    The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress ...