The short-term effects of air pollution on brain health have come under investigation only recently. Since environmental health studies are often developed entirely by scientists, citizen science is a promising approach ...

Introducción: El Trastorno Depresivo Mayor (TDM) es una enfermedad común que limita severamente el funcionamiento psicosocial y disminuye la calidad de vida. Clínicamente, el diagnóstico pasa por la entrevista clínica ...

Este proyecto se centra en el papel de las células senescentes durante la regeneración muscular desde varios ángulos. Para llevarlo a cabo, hemos desarrollado una técnica novedosa para poder aislar células senescentes ...

Specialization and plasticity are hallmarks of immune cells. Thus, charting their heterogeneity is crucial to understand their function and role in diseases. In this setting, single-cell RNA-sequencing (scRNA-seq) has ...

Sequencing of cancer genomes reveals the story of mutational events shaping the distribution of somatic mutations across the nucleotide sequence. A particular pattern of such distribution, mutational clustering, can inform ...

Certain skin disorders are associated with skin microbiome dysbiosis, highlighting the importance of the microbiome in the maintenance of the skin's healthy state. Modulating the microbiome to reestablish its healthy state ...

Cancer stem cells (CSCs) fuels tumours and are involved in therapy resistance, yet their contribution immunotherapy resistance and immunological properties are poorly understood. Herein, we show that within tumour phenotypic ...

The need for efficient targeted integration of large DNA fragments in mammalian genomes is indisputable, although several nuclease-based technologies have been lately developed for small allele genome editing. In this ...

L'exposició a factors de risc ambientals durant la vida intrauterina o la infància ha estat relacionada amb un major risc a desenvolupar diverses malalties. Tot i això, els mecanismes biològics subjacents són poc coneguts. ...

Els biomarcadors són un conjunt de signes mèdics objectius que són molt rellevants en l'àmbit clínic. La metabolòmica és la tècnica d'elecció per a establir biomarcadors. Centrar-se en una família específica de compostos ...