Visualitza per autoria "Raya Chamorro, Ángel"

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  • A protocol describing the genetic correction of somatic human cells and subsequent generation of IPS cell
    Rodríguez Pizà, Ignasi; Raya Chamorro, Ángel; Navarro, Susana; Izpisúa Belmonte, J. C.; Bueren, Juan; Consiglio, Antonella; Sánchez Danés, Adriana, 1984-; Guenechea, Guillermo; Richaud Patin, Yvonne (Nature Publishing Group, 2010)
    The generation of patient-specific induced pluripotent stem cells (iPSCPSCPSCs) offers unprecedented opportunities for modeling and treating human disease. In combination with gene therapy, the iPSCPSCPSC technology can ...
  • Derivation of human embryonic stem cells at the center for regenerative medicine in Barcelona
    Rodríguez Pizà, Ignasi; Raya Chamorro, Ángel; Aran, Begoña; Veiga, Anna; Izpisúa Belmonte, J. C.; Barri, Pere N.; Muñoz, Yolanda; Consiglio, Antonella (Springer, 2010)
    We report here the legislative issues related to/nembryo research and human embryonic stem cell (hESC)/nresearch in Spain and the derivation of nine hESC lines at/nthe Center of Regenerative Medicine in Barcelona. You ...
  • Development of xenobiotic-free conditions towards the generation and propagation of clinically-safe human pluripotent stem cells
    Rodríguez Pizà, Ignasi (Universitat Pompeu Fabra, 2011-04-12)
    Les cèl·lules mare embrionàries humanes (hESC) i més recentment les cèl·lules de pluripotència induïda (iPSC) representen una oportunitat sense precedents per al desenvolupament de noves estratègies terapèutiques per ...
  • Disease-corrected haematopoietic progenitors from Fanconi anemia induced pluripotent stem cells
    Rodríguez Pizà, Ignasi; Verma, Inder M.; Veiga, Anna; Aasen, Trond; Izpisúa Belmonte, J. C.; Bueren, Juan; Garreta Bahima, Elena; Tiscornia, Gustavo; Sleep Ronquillo, Eduard; Raya Chamorro, Ángel; Río, Paula; Consiglio, Antonella; Barrero Núñez, María José; Navarro, Susana; Vassena, Rita; Guenechea, Guillermo (Nature Publishing Group, 2009)
    The generation of induced pluripotent stem (iPS) cells has enabled the derivation of patient-specific pluripotent cells and/nprovided valuable experimental platforms to model human disease. Patient-specific iPS cells are ...
  • Generation of cardiomyocytes from new human embrionic stem cell lines derived from poor-quanlity blastocysts
    Raya Chamorro, Ángel; Rodríguez Pizà, Ignasi; Aran, Begoña; Consiglio, Antonella; Barri, Pere N.; Veiga, Anna; Izpisúa Belmonte, J. C. (Cold Spring Harbor Laboratory Press-CSHL Press, 2008)
    Human embryonic stem (hES) cells represent a potential source for cell replacement therapy of many degenerative diseases. Most frequently, hES cell lines are derived from surplus embryos from assisted reproduction cycles, ...
  • Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas
    Mazuelas, Helena; Magallón-Lorenz, Míriam; Fernández-Rodríguez, Juana; Uriarte-Arrazola, Itziar; Richaud Patin, Yvonne; Terribas, Ernest; Villanueva, Alberto; Castellanos, Elisabeth; Blanco, Ignacio; Raya Chamorro, Ángel; Chojnacki, Jakub; Heyn, Holger; Romagosa, Cleofé; Lázaro García, Conxi; Gel, Bernat; Carrió, Meritxell; Serra, Eduard (Elsevier, 2022)
    Plexiform neurofibromas (pNFs) are developmental tumors that appear in neurofibromatosis type 1 individuals, constituting a major source of morbidity and potentially transforming into a highly metastatic sarcoma (MPNST). ...
  • Molecular and cellular mechanisms of heart regeneration in zebrafish
    Sleep Ronquillo, Eduard (Universitat Pompeu Fabra, 2011-04-12)
    In contrast to mammals, zebrafish do have the ability to regenerate their heart after injury. A better understanding of how regenerationcompetent species do so should help developing strategies to enhance human cardiac ...
  • Parkinson's disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration
    Carola, Giulia; Malagarriga, Daniel; Calatayud, Carles; Pons Espinal, Meritxell, 1986-; Blasco Agell, Lucas; Richaud Patin, Yvonne; Fernández Carasa, Irene; Baruffi, Valentina; Beltramone, Santiago; Molina, Emilio; Dell'Era, Patrizia; Toledo Aral, Juan J.; Tolosa, Eduard; Muotri, Alysson R.; García Ojalvo, Jordi; Soriano Fradera, Jordi; Raya Chamorro, Ángel; Consiglio, Antonella (Nature Research, 2021)
    A deeper understanding of early disease mechanisms occurring in Parkinson's disease (PD) is needed to reveal restorative targets. Here we report that human induced pluripotent stem cell (iPSC)-derived dopaminergic neurons ...
  • Patient-specific iPSC-derived astrocytes contribute to non-cell-autonomous neurodegeneration in Parkinson's disease
    di Domenico, Angelique; Carola, Giulia; Calatayud, Carles; Pons Espinal, Meritxell, 1986-; Muñoz, Juan Pablo; Richaud Patin, Yvonne; Fernández Carasa, Irene; Gut, Marta; Faella, Armida; Parameswaran, Janani, 1990-; Soriano, Jordi; Ferrer, Isidre; Tolosa, Eduard; Zorzano, Antonio; Cuervo, Ana Maria; Raya Chamorro, Ángel; Consiglio, Antonella (Elsevier, 2019)
    Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell-autonomous contribution, in particular of astrocytes, ...
  • Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions
    Rodríguez Pizà, Ignasi; Vassena, Rita; Richaud Patin, Yvonne; Izpisúa Belmonte, J. C.; Raya Chamorro, Ángel; Veiga, Anna; Barrero Núñez, María José; González, Federico (AlphaMed Press and Wiley-Blackwell, 2010)
    The availability of induced pluripotent stem cells (iPSCs)/nhas created extraordinary opportunities for modeling and/nperhaps treating human disease. However, all reprogramming/nprotocols used to date involve the use of ...
  • Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson's disease patients
    Fernández-Santiago, Ruben; Merkel, Angelika; Castellano, Giancarlo; Heath, Simon; Raya Chamorro, Ángel; Tolosa, Eduard; Martí, Maria José; Consiglio, Antonella; Ezquerra, Mario (BioMed Central, 2019)
    Background: Parkinson’s disease (PD) is characterized by the loss of midbrain dopaminergic neurons (DAn). Previously, we described the presence of DNA hyper- and hypo-methylation alterations in induced pluripotent stem ...

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