Browsing by Author "Posas Garriga, Francesc"

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  • 3D-printing of transparent bio-microfluidic devices in PEG-DA
    Urrios Garcia, Arturo, 1990-; Parra-Cabrera, Cesar; Bhattacharjee, Nirveek; Gonzalez-Suarez, Alan M.; Rigat-Brugarolas, Luis G.; Nallapatti, Umashree; Samitier, Josep; DeForest, Cole A.; Posas Garriga, Francesc; Garcia-Cordero, José L.; Folch, Albert (Royal Society of Chemistry, 2016)
    The vast majority of microfluidic systems are molded in poly(dimethylsiloxane) (PDMS) by soft lithography due to the favorable properties of PDMS: biocompatible, elastomeric, transparent, gas-permeable, inexpensive, and ...
  • A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle
    Linke, Christian; Chasapi, Anastasia; González Novo, Alberto; Al-Sawad, Istabrak; Tognetti, Silvia; Klipp, E., 1965-; Loog, Mart; Krobitsch, Sylvia; Posas Garriga, Francesc; Xenarios, Ioannis; Barberis, Matteo (Nature Publishing Group, 2017)
    Precise timing of cell division is achieved by coupling waves of cyclin-dependent kinase (Cdk) activity with a transcriptional oscillator throughout cell cycle progression. Although details of transcription of cyclin genes ...
  • A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress
    Viéitez Manrique, Cristina, 1984-; Martínez Cebrián, Gerard, 1992-; Solé, Carme; Böttcher, René; Potel, Clement M.; Savitski, Mikhail M.; Onnebo, Sara; Fabregat, Marc; Shilatifard, Ali; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2020)
    Cells have the ability to sense, respond and adapt to environmental fluctuations. Stress causes a massive reorganization of the transcriptional program. Many examples of histone post-translational modifications (PTMs) have ...
  • A genome-wide functional screen identifies enhancer and protective genes for amyloid beta-peptide toxicity
    Picón-Pagès, Pol; Bosch Morató, Mònica, 1986-; Subirana, Laia; Rubio-Moscardó, Francisca; Guivernau Almazán, Biuse, 1988-; Fanlo-Ucar, Hugo; Zeylan, Melisa Ece; Senyuz, Simge; Herrera-Fernández, Víctor; Vicente García, Rubén, 1978-; Fernández-Fernández, José Manuel, 1967-; García Ojalvo, Jordi; Gursoy, Attila; Keskin, Ozlem; Oliva Miguel, Baldomero; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Muñoz López, Francisco José, 1964- (MDPI, 2023)
    Alzheimer's disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried ...
  • A novel mechanism for the prevention of transcription replication conflicts
    Canal de Torres, Berta, 1988-; Duch, Alba; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Taylor & Francis, 2018)
    Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a ...
  • Biological computation in yeast
    Conde Pueyo, Núria (Universitat Pompeu Fabra, 2015-11-19)
    Ongoing efforts within synthetic biology have been directed towards the building of artificial computational devices using engineered biological units as basic building blocks. Such efforts, are limited by the wiring ...
  • Biophysical properties of Saccharomyces cerevisiae and their relationship with HOG pathway activation
    Schaber, Jörg; Adrover Nadal, Miguel Angel; Eriksson, Emma; Pelet, Serge; Petelenz-Kurdziel, Elzbieta; Klein, Dagmara; Posas Garriga, Francesc; Goksör, Mattias; Peter, Matthias; Hohmann, Stefan; Klipp, E., 1965- (Springer Verlag, 2010)
    Parameterized models of biophysical and mechanical cell properties are important for predictive mathematical modeling of cellular processes. The concepts of turgor, cell wall elasticity, osmotically active volume, and ...
  • Control of Cdc28 CDK1 by a stress-induced lncRNA
    Nadal Ribelles, Mariona, 1984-; Solé, Carme; Xu, Zhenyu; Steinmetz, Lars M.; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2014)
    Genomic analysis has revealed the existence of a large number of long noncoding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Cells display dramatic changes of gene expression upon ...
  • Control of cell cycle progression by the last MAPK Hog1
    Escoté Miró, Xavier (Universitat Pompeu Fabra, 2011-04-12)
    Exposure of yeast to increases in extracellular osmolarity activates the stress-activated Hog1 MAP kinase, which is essential for cell survival upon osmotic stress. Activation of the Hog1 MAPK results in cell growth arrest, ...
  • Control of S-phase progression in response to stress
    Canal de Torres, Berta (Universitat Pompeu Fabra, 2018-06-06)
    In response to multiple internal and external stresses, yeast cells activate a common transcriptional response known as the Environmental Stress Response (ESR), which can be problematic in S phase, when DNA is being ...
  • Control of transcription by the stress activated Hog1 kinase
    Nadal Ribelles, Mariona, 1984- (Universitat Pompeu Fabra, 2015-05-27)
    A fundamental property of living cells is the ability to sense and robustly respond to fluctuations in their environment. In budding yeast (Saccharomyces cerevisiae) changes in extracellular osmolarity are sensed by the ...
  • Control of transcription initiation by the stress activated hog1 kinase
    Zapater Enrique, Meritxell (Universitat Pompeu Fabra, 2011-04-12)
    En el llevat Saccharomyces cerevisiae els canvis en les condicions osmòtiques del medi extracel.lular són sensades per la MAP cinasa Hog1, la qual permet dur a terme l'adaptació cel.lular mitjançant la modulació de l'expressió ...
  • Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress
    Solé, Carme; Nadal Ribelles, Mariona, 1984-; Kraft, Claudine; Peter, Matthias; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Nature Publishing Group, 2011)
    Protein ubiquitylation is a key process in the regulation of many cellular processes. The balance between the activity of ubiquitin ligases and that of proteases controls the level of ubiquitylation. In response to ...
  • Data-driven identification of inherent features of eukaryotic stress-responsive genes
    Latorre Doménech, Pablo, 1993-; Böttcher, René; Nadal Ribelles, Mariona, 1984-; Li, Constance H.; Solé, Carme; Martínez Cebrián, Gerard, 1992-; Boutros, Paul C.; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2022)
    Living organisms are continuously challenged by changes in their environment that can propagate to stresses at the cellular level, such as rapid changes in osmolarity or oxygen tension. To survive these sudden changes, ...
  • Dealing with transcriptional outbursts during S phase to protect genomic integrity
    Duch, Alba; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2013)
    Transcription during S phase needs to be spatially and temporally regulated to prevent collisions between the transcription and replication machineries. Cells have evolved a number of mechanisms to make both processes ...
  • Decoding the nature of the transcriptional response to stress
    Latorre Doménech, Pablo (2021-06-16)
    Virtually all living organisms are challenged by changes in their environment, such as sudden increases in osmolarity. To cope with these stresses, cells have developed stress responses that tune every aspect of cell ...
  • Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases
    Klein, Michael; Morillas, Montse; Vendrell Arasa, Alexandre; Brive, Lars; Gebbia, Marinella; Wallace, Iain M; Giaever, Guri; Nislow, Corey; Posas Garriga, Francesc; Grotli, Morten (Public Library of Science (PLoS), 2011)
    Highly selective, cell-permeable and fast-acting inhibitors of individual kinases are sought-after as tools for studying the cellular function of kinases in real time. A combination of small molecule synthesis and protein ...
  • Distributed computation in multicellular synthetic networks
    Urrios Garcia, Arturo (Universitat Pompeu Fabra, 2018-12-13)
    Biological systems gather information from the environment and perform computations at multiple levels. Advancements in molecular biology and techniques for cell manipulation, genome engineering and DNA synthesis among ...
  • Functional network analysis reveals the relevance of SKIIP in the regulation of alternative splicing by p38 SAPK
    Carbonell Núñez, Caterina, 1987-; Ulsamer, Arnau; Vivori, Claudia, 1989-; Papasaikas, Panagiotis; Böttcher, René; Joaquin i Caudet, Manel; Miñana Gómez, Belén; Tejedor Vaquero, Juan Ramón, 1984-; Nadal Clanchet, Eulàlia de; Valcárcel, J. (Juan); Posas Garriga, Francesc (Elsevier, 2019)
    Alternative splicing is a prevalent mechanism of gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps ...
  • H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes
    Nadal Ribelles, Mariona, 1984-; Mas Martín, Glòria; Millán Zambrano, Gonzalo; Solé, Carme; Ammerer, Gustav; Chávez, Sebastián; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2015)
    Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important regulator of transcription that mediates chromatin remodeling upon stress. Hog1 targets the RSC ...

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