Visualitza per autor "Posas Garriga, Francesc"

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  • Conde Pueyo, Núria, 1983- (Universitat Pompeu Fabra, 2014-09-18)
    Ongoing efforts within synthetic biology have been directed towards the building of artificial computational devices using engineered biological units as basic building blocks. Such efforts, are limited by the wiring ...
  • Schaber, Jörg; Adrover, Miquel Àngel; Eriksson, Emma; Pelet, Serge; Petelenz-Kurdziel, Elzbieta; Klein, Dagmara; Posas Garriga, Francesc; Goksör, Mattias; Peter, Matthias; Hohmann, Stefan; Klipp, E., 1965- (Springer Verlag, 2010)
    Parameterized models of biophysical and mechanical cell properties are important for predictive mathematical modeling of cellular processes. The concepts of turgor, cell wall elasticity, osmotically active volume, and ...
  • Nadal Ribelles, Mariona, 1984-; Solé, Carme; Xu, Zhenyu; Steinmetz, Lars M.; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2014)
    Genomic analysis has revealed the existence of a large number of long noncoding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Cells display dramatic changes of gene expression upon ...
  • Escoté Miró, Xavier (Universitat Pompeu Fabra, 2005-10-06)
    Exposure of yeast to increases in extracellular osmolarity activates the stress-activated Hog1 MAP kinase, which is essential for cell survival upon osmotic stress. Activation of the Hog1 MAPK results in cell growth arrest, ...
  • Nadal Ribelles, Mariona, 1984- (Universitat Pompeu Fabra, 2013-11-25)
    A fundamental property of living cells is the ability to sense and robustly respond to fluctuations in their environment. In budding yeast (Saccharomyces cerevisiae) changes in extracellular osmolarity are sensed by the ...
  • Zapater Enrique, Meritxell (Universitat Pompeu Fabra, 2006-12-01)
    En el llevat Saccharomyces cerevisiae els canvis en les condicions osmòtiques del medi extracel.lular són sensades per la MAP cinasa Hog1, la qual permet dur a terme l'adaptació cel.lular mitjançant la modulació de l'expressió ...
  • Solé, Carme; Nadal Ribelles, Mariona, 1984-; Kraft, Claudine; Peter, Matthias; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Nature Publishing Group, 2011)
    Protein ubiquitylation is a key process in the regulation of many cellular processes. The balance between the activity of ubiquitin ligases and that of proteases controls the level of ubiquitylation. In response to ...
  • Duch, Alba; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2013)
    Transcription during S phase needs to be spatially and temporally regulated to prevent collisions between the transcription and replication machineries. Cells have evolved a number of mechanisms to make both processes ...
  • Klein, Michael; Morillas, Montse; Vendrell Arasa, Alexandre; Brive, Lars; Gebbia, Marinella; Wallace, Iain M; Giaever, Guri; Nislow, Corey; Posas Garriga, Francesc; Grotli, Morten (Public Library of Science (PLoS), 2011)
    Highly selective, cell-permeable and fast-acting inhibitors of individual kinases are sought-after as tools for studying the cellular function of kinases in real time. A combination of small molecule synthesis and protein ...
  • Nadal Ribelles, Mariona, 1984-; Mas Martín, Glòria; Millán Zambrano, Gonzalo; Solé, Carme; Ammerer, Gustav; Chávez, Sebastián; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2015)
    Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important regulator of transcription that mediates chromatin remodeling upon stress. Hog1 targets the RSC ...
  • Nadal Ribelles, Mariona, 1984-; Conde Pueyo, Núria, 1983-; Flores, Oscar; González-Vallinas Rostes, Juan, 1983-; Eyras Jiménez, Eduardo; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (BioMed Central, 2012)
    Cells are subjected to dramatic changes of gene expression upon environmental changes. Stress/ncauses a general down-regulation of gene expression together with the induction of a set of stress-responsive/ngenes. The ...
  • Macía, Javier; Manzoni, Romilde; Conde Pueyo, Núria, 1983-; Urrios, Arturo; Nadal Clanchet, Eulàlia de; Solé Vicente, Ricard, 1962-; Posas Garriga, Francesc (Public Library of Science (PLoS), 2016)
    Engineered synthetic biological devices have been designed to perform a variety of functions from sensing molecules and bioremediation to energy production and biomedicine. Notwithstanding, a major limitation of in vivo ...
  • Stojanovski, Klement; Ferrar, Tony; Benisty, Hannah; Uschner, Friedemann; Delgado, Javier; Jimenez, Javier; Solé, Carme; Nadal Clanchet, Eulàlia de; Klipp, Edda; Posas Garriga, Francesc; Serrano Pubull, Luis, 1982-; Kiel, Christina (Elsevier, 2017)
    The understanding of interaction dynamics in signaling pathways can shed light on pathway architecture and provide insights into targets for intervention. Here, we explored the relevance of kinetic rate constants of a key ...
  • Mas Martín, Glòria (Universitat Pompeu Fabra, 2007-07-20)
    En la levadura S. cerevisiae, un incremento de la osmolaridad extracelular activa la vía de Hog1, lo que produce una compleja respuesta adaptativa. Entre las respuestas adaptativas que Hog1 coordina, está un importante ...
  • Solé, Carme; Nadal Ribelles, Mariona, 1984-; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Springer, 2015)
    Eukaryotic cells have developed sophisticated systems to constantly monitor changes in the extracellular environment and to orchestrate a proper cellular response. To maximize survival, cells delay cell-cycle progression ...
  • Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Wiley, 2015)
    Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are ...
  • Sharifian, Hoda; Lampert, Fabienne; Stojanovski, Klement; Regot Rodríguez de Mier, Sergi; Vaga, Stefania; Buser, Raymond; Lee, Sung Sik; Koeppl, Heinz; Posas Garriga, Francesc; Pelet, Serge; Peter, Matthias (Royal Society of Chemistry, 2015)
    Tight regulation of the MAP kinase Hog1 is crucial for survival under changing osmotic conditions. Interestingly, we found that Hog1 phosphorylates multiple upstream components, implying feedback regulation within the ...
  • Adrover Nadal, Miguel Angel (Universitat Pompeu Fabra, 2009-09-18)
    Control of cell cycle by Stress Activated Protein Kinases (SAPKs) is an essential aspect for adaptation to extracellular stimuli. In Saccharomyces cerevisiae, the activation of the Hog1 SAPK, results in a delayed transcription ...
  • Ruiz Roig, Clàudia (Universitat Pompeu Fabra, 2011-12-02)
    A Saccharomyces cerevisiae, un increment de la temperatura comporta diversosefectes deleteris en l’organització interna de la cèl∙lula i indueix una inducció ràpida,massiva i transitòria d’expressió gènica, que es controla ...
  • Saito, Haruo; Posas Garriga, Francesc (Genetics Society of America, 2012)
    An appropriate response and adaptation to hyperosmolarity, i.e., an external osmolarity that is higher than the physiological range, can be a matter of life or death for all cells. It is especially important for free-living ...