Browsing by Author "Oliva Miguel, Baldomero"

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  • Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Valls Comamala, Victòria, 1987-; Bosch Morató, Mònica, 1986-; Godoy Zeballos, Juan Alejandro, 1959-; Inestrosa, Nibaldo C.; Perálvarez Marín, Alex; Fernández-Busquets, Xavier; Andreu Martínez, David; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Society for Neuroscience, 2016)
    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal to β-sheet conformation, promoting its ...
  • Güney, Emre, 1983-; Oliva Miguel, Baldomero (Public Library of Science (PLoS), 2014)
    Complex biological systems usually pose a trade-off between robustness and fragility where a small number of perturbations can substantially disrupt the system. Although biological systems are robust against changes in ...
  • Bonet Martínez, Jaume, 1982-; Planas Iglesias, Joan, 1980-; García-García, Javier, 1982-; Marín López, Manuel Alejandro, 1987-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2014)
    The function of a protein is determined by its three-dimensional structure, which is formed by regular (i.e. β-strands and α-helices) and non-periodic structural units such as loops. Compared to regular structural elements, ...
  • Gitter, Anthony; Siegfried, Zehava; Klutstein, Michael; Fornés Crespo, Oriol, 1983-; Oliva Miguel, Baldomero; Simon, Itamar; Bar-Joseph, Ziv (EMBO Press, 2009)
    The complementarity of gene expression and protein-DNA interaction data led to several successful models of biological systems. However, recent studies in multiple species raise doubts about the relationship between these ...
  • García-García, Javier, 1982-; Güney, Emre, 1983-; Aragüés Peleato, Ramón; Planas Iglesias, Joan, 1980-; Oliva Miguel, Baldomero (BioMed Central, 2010)
    Background: The analysis and usage of biological data is hindered by the spread of information across multiple repositories and the difficulties posed by different nomenclature systems and storage formats. In particular, ...
  • García-García, Javier, 1982-; Schleker, Sylvia; Klein-Seetharaman, Judith; Oliva Miguel, Baldomero (Oxford University Press, 2012)
    Protein-protein interactions (PPIs) play a crucial role in biology, and high-throughput experiments have greatly increased the coverage of known interactions. Still, identification of complete inter- and intraspecies ...
  • Segura, Joan; Oliva Miguel, Baldomero; Fernández Fuentes, Narcís (Oxford University Press, 2012)
    The regions of the polypeptide chain immediately preceding or following an α-helix are known as Nt- and Ct cappings, respectively. Cappings play a central role stabilizing α-helices due to lack of intrahelical hydrogen ...
  • Wright, Roni H.G.; Castellano, Giancarlo; Bonet Martínez, Jaume, 1982-; Le Dily, François; Font Mateu, Jofre, 1977-; Ballaré, Cecilia Julia; Nacht, A. Silvina; Soronellas, Daniel; Oliva Miguel, Baldomero; Beato, Miguel (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Eukaryotic gene regulation implies that transcription factors gain access to genomic information via poorly understood processes involving activation and targeting of kinases, histone-modifying enzymes, and chromatin ...
  • Boada Centeno, Núria; Planas Iglesias, Joan, 1980-; Oliva Miguel, Baldomero (BioMed Central, 2005)
    Comparative modeling is becoming an increasingly helpful technique in microbial cell factories as the knowledge of the three-dimensional structure of a protein would be an invaluable aid to solve problems on protein ...
  • Aguilar, Daniel; Pinart, Mariona; Benet, Marta; García Aymerich, Judith; González Ruiz, Juan Ramón; Guerra, Stefano; Kogevinas, Manolis; Sunyer Deu, Jordi; Valverde, Sergi; Oliva Miguel, Baldomero; Antó i Boqué, Josep Maria (Public Library of Science (PLoS), 2017)
    Background: The mechanisms explaining the co-existence of asthma, eczema and rhinitis (allergic multimorbidity) are largely unknown. We investigated the mechanisms underlying multimorbidity between three main allergic ...
  • Sieberts, Solveig K.; García-García, Javier, 1982-; Aguilar, Daniel; Anton, Bernat; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Marín López, Manuel Alejandro, 1987-; Planas Iglesias, Joan, 1980-; Poglayen, Daniel, 1984-; Oliva Miguel, Baldomero; Mangravite, Lara M. (Nature Publishing Group, 2016)
    Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widelyused to reduce disease progression, treatment fails inBone-third of patients. No biomarkercurrently exists that identifies non-responders ...
  • Salat Canela, Clàudia; Paulo Mirasol, Esther, 1984-; Sánchez Mir, Laura; Carmona, Mercè; Ayté del Olmo, José; Oliva Miguel, Baldomero; Hidalgo Hernando, Elena (American Society for Biochemistry and Molecular Biology (ASBMB), 2017)
    Adaptation to stress triggers the most dramatic shift in gene expression in fission yeast (Schizosaccharomyces pombe), and this response is driven by signaling via the MAPK Sty1. Upon activation, Sty1 accumulates in the ...
  • Salgado Mendialdúa, Victòria; Aguirre Plans, Joaquim; Guney, Emre; Reig-Viader, Rita; Maldonado, Rafael, 1961-; Bayés, Angels; Oliva Miguel, Baldomero; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2018)
    Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type-1 ...
  • Poglayen, Daniel, 1984- (Universitat Pompeu Fabra, 2016-01-28)
    Cellular behaviour is regulated by a very precise system in which the complex interplay between various types of biomolecules plays a crucial role for the proper functioning of the system itself. Proteins interacting with ...
  • Bonet Martínez, Jaume, 1982- (Universitat Pompeu Fabra, 2015-01-30)
    Proteins are the basic functional and structural blocks of life. Knowledge of their structure and function is key to understand how it works. Lately, the gap between new discovered proteins and systematically studied ones ...
  • Güney, Emre, 1983-; Oliva Miguel, Baldomero (Public Library of Science (PLoS), 2012)
    Complex genetic disorders often involve products of multiple genes acting cooperatively. Hence, the pathophenotype is the outcome of the perturbations in the underlying pathways, where gene products cooperate through various ...
  • Sanz Pamplona, Rebeca; Aragüés Peleato, Ramón; Driouch, Keltouma; Martín, Berta; Oliva Miguel, Baldomero; Gil, Miguel; Boluda, Susana; Fernández, Pedro L.; Martínez, Antonio; Moreno, Víctor; Acebes, Juan J.; Lidereau, Rosette; Reyal, Fabien; Van de Vijver, Marc J.; Sierra, Angels (Elsevier, 2011)
    The increasing incidence of breast cancer brain metastasis in patients with otherwise well-controlled systemic cancer is a key challenge in cancer research. It is necessary to understand the properties of brain-tropic tumor ...
  • Martínez Aranda, Antonio; Hernández, Vanessa; Güney, Emre, 1983-; Muixí, Laia; Foj, Ruben; Baixeras, Núria; Cuadras, Daniel; Moreno, Víctor; Urruticoechea, Ander; Gil, Miguel; Oliva Miguel, Baldomero; Moreno, Ferran; González Suárez, Eva; Vidal, Noemí; Andreu, Xavier; Seguí, Miquel A.; Ballester, Rosa; Castella, Eva; Sierra, Angels (Impact Journals, 2015)
    Brain metastasis is a devastating problem in patients with breast, lung and melanoma tumors. GRP94 and FN14 are predictive biomarkers over-expressed in primary breast carcinomas that metastasized in brain. To further ...
  • Aguilar, Daniel; Oliva Miguel, Baldomero (BioMed Central, 2012)
  • Rubio Pérez, Carlota, 1990-; Güney, Emre, 1983-; Aguilar, Daniel; Piñero González, Janet, 1977-; García-García, Javier, 1982-; Iadarola, Barbara; Sanz, Ferran; Fernández Fuentes, Narcís; Furlong, Laura I., 1971-; Oliva Miguel, Baldomero (Nature Publishing Group, 2017)
    Understanding relationships between diseases, such as comorbidities, has important socio-economic implications, ranging from clinical study design to health care planning. Most studies characterize disease comorbidity using ...