Visualitza per autor "Navarro Medrano, Pilar"

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  • Jungfleisch, Jennifer, 1986-; Nedialkova, Danny D.; Dotu, Ivan; Sloan, Katherine E.; Martínez Bosch, Neus; Brüning, Lukas; Raineri, Emanuele; Navarro Medrano, Pilar; Bohnsack, Markus T.; Leidel, Sebastian; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)
    The impact of RNA structures in coding sequences (CDS) within mRNAs is poorly understood. Here, we identify a novel and highly conserved mechanism of translational control involving RNA structures within coding sequences ...
  • Mohan, Ram (Universitat Pompeu Fabra, 2011-05-30)
    El adenocarcinoma ductal pancreático (PDAC) es la quinta causa de muerte por cánceren los países desarrollados y uno de los tumores humanos más agresivos. A pesar delpapel clave de la angiogénesis -la formación de nuevos ...
  • Roda Noguera, Oriol (Universitat Pompeu Fabra, 2006-05-30)
    El càncer de pàncrees és altament agressiu i representa la cinquena causa de mort al mon occidental. Anteriorment, en el nostre laboratori, vam identificar que el receptor tissular del plasminogen (tPA) hi està sobre-expressat ...
  • Martínez Bosch, Neus (Universitat Pompeu Fabra, 2011-09-26)
    Pancreatic cancer is nowadays one of the neoplasms with worst prognosis, so researchtowards the discovery of new molecular targets for therapy and diagnosis is more thanurgent. In this direction, we have deeply evaluated ...
  • Aguilar Izquierdo, Susana (Universitat Pompeu Fabra, 2004-02-26)
    Exocrine pancreatic cancer is the fifth leading cause of death from malignant disease in Western society and it is one of the most aggressive human tumors. Once diagnosed, the 12-month patient survival is less than 5%. ...
  • Martínez Bosch, Neus; Fernández-Zapico, Martin E.; Navarro Medrano, Pilar; Yelamos López, Jose (Elsevier, 2016)
    The poly(ADP-ribose) polymerase (PARP) enzymes were initially characterized as sensors of DNA breaks but are now known to play key roles not only in the DNA damage response but also in regulating numerous molecular processes, ...
  • Loubat Casanovas, Jordina, 1982-; Peña, Raúl; Gonzàlez, Núria; Alba Castellón, Lorena, 1984-; Rosell, Santi; Francí i Carreté, Clara; Navarro Medrano, Pilar; García de Herreros, Antonio (Impact Journals, 2016)
    The Snail1 transcriptional factor is required for correct embryonic development, yet its expression in adult animals is very limited and its functional roles are not evident. We have now conditionally inactivated Snail1 ...
  • Martínez Bosch, Neus; Enrique Guerrero, Pedro; Moreno, Mireia; José Segarra-Martínez, Anabel; Iglesias García, Mar; Munné-Collado, Jessica; Anta, Héctor; Gibert, Joan; Orozco, Carlos Alberto; Vinaixa, Judith; Fillat i Fonts, Cristina; Viñals, Francesc; Navarro Medrano, Pilar (Impact Journals, 2016)
    Current treatments for pancreatic ductal adenocarcinoma (PDA) are ineffective, making this the 4th leading cause of cancer deaths. Sunitinib is a broad-spectrum inhibitor of tyrosine kinase receptors mostly known for its ...