Browsing by Author "Navarro Medrano, Pilar"

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  • Jungfleisch, Jennifer, 1986-; Nedialkova, Danny D.; Dotu, Ivan; Sloan, Katherine E.; Martínez Bosch, Neus; Brüning, Lukas; Raineri, Emanuele; Navarro Medrano, Pilar; Bohnsack, Markus T.; Leidel, Sebastian; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)
    The impact of RNA structures in coding sequences (CDS) within mRNAs is poorly understood. Here, we identify a novel and highly conserved mechanism of translational control involving RNA structures within coding sequences ...
  • Mohan, Ram (Universitat Pompeu Fabra, 2011-05-30)
    El adenocarcinoma ductal pancreático (PDAC) es la quinta causa de muerte por cáncer en los países desarrollados y uno de los tumores humanos más agresivos. A pesar del papel clave de la angiogénesis -la formación de nuevos ...
  • Roda Noguera, Oriol (Universitat Pompeu Fabra, 2006-05-30)
    El càncer de pàncrees és altament agressiu i representa la cinquena causa de mort al mon occidental. Anteriorment, en el nostre laboratori, vam identificar que el receptor tissular del plasminogen (tPA) hi està sobre-expressat ...
  • Martínez Bosch, Neus (Universitat Pompeu Fabra, 2011-09-26)
    Pancreatic cancer is nowadays one of the neoplasms with worst prognosis, so research towards the discovery of new molecular targets for therapy and diagnosis is more than urgent. In this direction, we have deeply evaluated ...
  • Anta Rodríguez, Héctor, 1988- (Universitat Pompeu Fabra, 2016-12-15)
    Alzheimer’s disease (AD) is the most common type of dementia in the elderly. It is associated to a progressive loss of memory, problems in learning and behaviour changes. This disease is characterized by the accumulation ...
  • Martínez Bosch, Neus; Vinaixa, Judith; Navarro Medrano, Pilar (MDPI, 2018)
    Pancreatic ductal adenocarcinoma (PDA), the most frequent type of pancreatic cancer, remains one of the most challenging problems for the biomedical and clinical fields, with abysmal survival rates and poor therapy efficiency. ...
  • Gibert Fernandez, Joan 1988- (Universitat Pompeu Fabra, 2017-11-08)
    Cytoplasmic polyadenylation binding proteins (CPEB) are a family of RNA binding proteins which control the translation of its target mRNAs by modulating the length poly(A) mRNA tail. Cytoplasmic polyadenylation was originally ...
  • Aguilar Izquierdo, Susana (Universitat Pompeu Fabra, 2004-02-26)
    Exocrine pancreatic cancer is the fifth leading cause of death from malignant disease in Western society and it is one of the most aggressive human tumors. Once diagnosed, the 12-month patient survival is less than 5%. ...
  • Martínez Bosch, Neus; Fernández-Zapico, Martin E.; Navarro Medrano, Pilar; Yelamos López, Jose (Elsevier, 2016)
    The poly(ADP-ribose) polymerase (PARP) enzymes were initially characterized as sensors of DNA breaks but are now known to play key roles not only in the DNA damage response but also in regulating numerous molecular processes, ...
  • Mancebo Moreno, Gemma; Sole-Sedeno, J.M.; Pino, O.; Miralpeix, E.; Mojal, Sergio; Garrigos, L.; Lloveras Rubio, Belen; Navarro Medrano, Pilar; Gibert, Joan; Lorenzo Perez, Marta; Aran, Iris; Carreras Collado, Ramón; Alameda Quitllet, Francisco (Nature Publishing Group, 2017)
    To assess the impact of CD133 expression on the prognosis of endometrioid endometrial carcinoma (EEC). We retrospectively assessed CD133 expression in tissue microarray of 116 surgically treated FIGO I-III EEC. Tumors with ...
  • Vinaixa Forner, Judit, 1991- (Universitat Pompeu Fabra, 2019-03-25)
    Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive tumors; mostly due to its lack of symptoms, resulting in late diagnosis, and also due to the presence of an aggressive tumor microenvironment. Importantly, ...
  • Loubat Casanovas, Jordina, 1982-; Peña, Raúl; Gonzàlez, Núria; Alba Castellón, Lorena, 1984-; Rosell, Santi; Francí i Carreté, Clara; Navarro Medrano, Pilar; García de Herreros, Antonio (Impact Journals, 2016)
    The Snail1 transcriptional factor is required for correct embryonic development, yet its expression in adult animals is very limited and its functional roles are not evident. We have now conditionally inactivated Snail1 ...
  • Orozco, Carlos Alberto; Martínez Bosch, Neus; Enrique Guerrero, Pedro; Vinaixa, Judith; Dalotto-Moreno, Tomás; Iglesias García, Mar; Moreno, Mireia; Djurec, Magdolna; Poirier, Françoise; Gabius, Hans J.; Fernández-Zapico, Martin E.; Hwang, Rosa F.; Guerra, Carmen; Rabinovich, Gabriel A.; Navarro Medrano, Pilar (National Academy of Sciences, 2018)
    Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to standard therapies. A more comprehensive understanding of the ...
  • Martínez Bosch, Neus; Enrique Guerrero, Pedro; Moreno, Mireia; José Segarra-Martínez, Anabel; Iglesias García, Mar; Munné-Collado, Jessica; Anta, Héctor; Gibert, Joan; Orozco, Carlos Alberto; Vinaixa, Judith; Fillat i Fonts, Cristina; Viñals, Francesc; Navarro Medrano, Pilar (Impact Journals, 2016)
    Current treatments for pancreatic ductal adenocarcinoma (PDA) are ineffective, making this the 4th leading cause of cancer deaths. Sunitinib is a broad-spectrum inhibitor of tyrosine kinase receptors mostly known for its ...
  • Villanueva, Eneko; Navarro Medrano, Pilar; Rovira-Rigau, Maria; Sibilio, Annarita; Méndez Giraldez, Raúl; Fillat i Fonts, Cristina (Nature Publishing Group, 2017)
    Systemic treatment of cancer requires tumour-selective therapies that eliminate cancer cells yet preserve healthy tissues from undesired damage. Tumoral transformation is associated with profound effects in translational ...