Visualitza per autor "Muñoz Cánoves, Pura, 1962-"

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  • Mann, Christopher J.; Perdiguero, Eusebio, 1968-; Kharraz, Yacine; Aguilar, Susana; Pessina, Patrizia; Serrano, Antonio L; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2011)
    The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resident stem ...
  • Vidal Iglesias, Berta; Ardite, Esther; Suelves, Mònica; Ruiz Bonilla, Vanesa, 1979-; Janué, Anna; Flick, Matthew J.; Degen, Jay L.; Serrano, Antonio L; Muñoz Cánoves, Pura, 1962- (Oxford University Press, 2012)
    In Duchenne muscular dystrophy (DMD), a persistently altered and reorganizing extracellular matrix (ECM) within inflamed muscle promotes damage and dysfunction. However, the molecular determinants of the ECM that mediate ...
  • García Prat, Laura; Martínez Vicente, Marta; Muñoz Cánoves, Pura, 1962- (Impact Journals, 2016)
    Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate ...
  • Segalés Dalmau, Jessica; Islam, Abul, 1978-; Kumar, Roshan; Liu, Qi-Cai; Sousa-Victor, Pedro; Dilworth, F. Jeffrey; Ballestar, Esteban; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2016)
    Background: Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although ...
  • Sousa-Victor, Pedro; García-Prat, Laura, 1987-; Muñoz Cánoves, Pura, 1962- (Impact Journals, 2015)
    Over the past decade, our understanding of the molecular and cellular mechanisms presiding over cellular and tissue decline with aging has greatly advanced. Classical hallmarks of aging cell include increasing levels of ...
  • Künnemann, Kathi, 1982- (Universitat Pompeu Fabra, 2013-09-13)
    Cyclin O, a novel identified Cdk1 and Cdk2-binding cyclin, has been demonstrated tobe required for apoptosis induced by intrinsic apoptotic stimuli. Because proteinsimplicated in apoptosis are often deregulated in cancer, ...
  • Pessina, Patrizia; Kharraz, Yacine; Jardí, Mercè; Fukada, So-ichiro; Serrano, Antonio L; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Elsevier, 2015)
    Preservation of cell identity is necessary for homeostasis of most adult tissues. This process is challenged every time a tissue undergoes regeneration after stress or injury. In the lethal Duchenne muscular dystrophy ...
  • Muñoz Cánoves, Pura, 1962-; Scheele, Camilla; Pedersen, Bente K.; Serrano, Antonio L (Wiley, 2013)
    Interleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. ...
  • Kharraz, Yacine; Guerra, Joan; Mann, Christopher J.; Serrano, Antonio L; Muñoz Cánoves, Pura, 1962- (Hindawi, 2013)
    Effective repair of damaged tissues and organs requires the coordinated action of several cell types, including infiltrating inflammatory cells and resident cells. Recent findings have uncovered a central role for macrophages ...
  • Pessina, Patrizia; Cabrera, Daniel; Morales, María Gabriela; Riquelme, Cecilia A; Gutiérrez, Jaime; Serrano, Antonio L; Brandan, Enrique; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2014)
    Background: Fibrosis, an excessive collagen accumulation, results in scar formation, impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies, including the lethal Duchenne muscular ...
  • José Segarra-Martínez, Anabel (Universitat Pompeu Fabra, 2011-12-13)
    Els tractaments actuals pel càncer de pàncreas presenten un eficàcia limitada de manera que es necessari el desenvolupament de noves teràpies antitumorals. La teràpia gènica pel càncer de pàncreas basada en l’ús d’adenovirus ...
  • Perdiguero, Eusebio, 1968-; Sousa-Victor, Pedro; Ruiz Bonilla, Vanesa, 1979-; Jardí, Mercè; Caelles Franch, Carme; Serrano, Antonio L; Muñoz Cánoves, Pura, 1962- (Rockefeller University Press, 2011)
    Repair of damaged tissue requires the coordinated action of inflammatory and tissue-specific cells to restore homeostasis, but the underlying regulatory mechanisms are poorly understood. In this paper, we report new roles ...
  • Ardite, Esther; Perdiguero, Eusebio, 1968-; Vidal Iglesias, Berta; Gutarra, Susana; Serrano, Antonio L; Muñoz Cánoves, Pura, 1962- (Rockefeller University Press, 2012)
    There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for ...
  • Bengal, Eyal; Perdiguero, Eusebio, 1968-; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (F1000Research, 2017)
    Adult muscle stem cells, originally called satellite cells, are essential for muscle repair and regeneration throughout life. Besides a gradual loss of mass and function, muscle aging is characterized by a decline in the ...
  • Victor, Pedro Sousa (Universitat Pompeu Fabra, 2012-02-27)
    Muscle aging, in particular, is characterized by the reduction of tissue mass and function, which are particularly prominent in geriatric individuals undergoing sarcopenia. The age-associated muscle wasting is also associated ...
  • Vidal Iglesias, Berta (Universitat Pompeu Fabra, 2008-09-17)
    Duchenne muscular dystrophy (DMD) is a fatal degenerative disorder of locomotor and respiratory muscles, in which myofibers are progressively replaced by non-muscular fibrotic tissue. Here, we show that fibrin/ogen accumulates ...
  • Brack, Andrew S.; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2016)
    Skeletal muscle has a remarkable capacity to regenerate by virtue of its resident stem cells (satellite cells). This capacity declines with aging, although whether this is due to extrinsic changes in the environment and/or ...
  • Kharraz, Yacine; Guerra, Joana; Pessina, Patrizia; Serrano, Antonio L; Muñoz Cánoves, Pura, 1962- (Hindawi, 2014)
    Fibrosis is the aberrant deposition of extracellular matrix (ECM) components during tissue healing leading to loss of its architecture and function. Fibrotic diseases are often associated with chronic pathologies and occur ...