Browsing by Author "Muñoz Cánoves, Pura, 1962-"

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  • Mann, Christopher J.; Perdiguero, Eusebio, 1968-; Kharraz, Yacine; Aguilar, Susana; Pessina, Patrizia; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2011)
    The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resident stem ...
  • Solanas, Guiomar; Oliveira Peixoto, Francisca; Perdiguero, Eusebio, 1968-; Jardí, Mercè; Ruiz Bonilla, Vanesa, 1979-; Datta, Debayan; Symeonidi, Aikaterini; Castellanos, Andrés; Welz, Patrick-Simon; Martín Caballero, Juan; Sassone-Corsi, Paolo; Muñoz Cánoves, Pura, 1962-; Aznar Benitah, Salvador (Elsevier, 2017)
    Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their ...
  • Vidal Iglesias, Berta; Ardite, Esther; Suelves, Mònica; Ruiz Bonilla, Vanesa, 1979-; Janué, Anna; Flick, Matthew J.; Degen, Jay L.; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Oxford University Press, 2012)
    In Duchenne muscular dystrophy (DMD), a persistently altered and reorganizing extracellular matrix (ECM) within inflamed muscle promotes damage and dysfunction. However, the molecular determinants of the ECM that mediate ...
  • García Prat, Laura; Martínez Vicente, Marta; Muñoz Cánoves, Pura, 1962- (Impact Journals, 2016)
    Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate ...
  • López Arribillaga, Erika; Rodilla, Verónica; Pellegrinet, Luca; Guiu Sagarra, Jordi, 1983-; Iglesias Coma, Mar; Roman, Angel Carlos; Gutarra, Susana; González, Susana; Muñoz Cánoves, Pura, 1962-; Fernández-Salguero, Pedro; Radtke, Freddy; Bigas Salvans, Anna; Espinosa Blay, Lluís (Company of Biologists, 2015)
    Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation ...
  • López-Luppo, Mariana; Catita, Joana; Ramos, David; Navarro, Marc; Carretero, Ana; Mendes Jorge, Luísa; Muñoz Cánoves, Pura, 1962-; Rodriguez-Baeza, Alfonso; Nacher, Víctor; Ruberte, Jesús (Association for Research in Vision and Ophthalmology (ARVO), 2017)
    Purpose: Microaneurysms are present in healthy old-age human retinas. However, to date, no age-related pathogenic mechanism has been implicated in their formation. Here, cellular senescence, a hallmark of aging and several ...
  • Segalés Dalmau, Jessica; Islam, Abul, 1978-; Kumar, Roshan; Liu, Qi-Cai; Sousa-Victor, Pedro; Dilworth, F. Jeffrey; Ballestar, Esteban; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2016)
    Background: Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although ...
  • Perdiguero, Eusebio, 1968-; Serrano Sánchez, Antonio L.; Muñoz Cánoves, Pura, 1962- (Elsevier, 2017)
    Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the ...
  • Sousa-Victor, Pedro; García-Prat, Laura, 1987-; Muñoz Cánoves, Pura, 1962- (Impact Journals, 2015)
    Over the past decade, our understanding of the molecular and cellular mechanisms presiding over cellular and tissue decline with aging has greatly advanced. Classical hallmarks of aging cell include increasing levels of ...
  • Muñoz Cánoves, Pura, 1962-; Carvajal, Jaime J.; López de Munain, Adolfo; Izeta, Ander (Frontiers, 2016)
  • Künnemann, Kathi, 1982- (Universitat Pompeu Fabra, 2013-09-13)
    Cyclin O, a novel identified Cdk1 and Cdk2-binding cyclin, has been demonstrated to be required for apoptosis induced by intrinsic apoptotic stimuli. Because proteins implicated in apoptosis are often deregulated in cancer, ...
  • Pessina, Patrizia; Kharraz, Yacine; Jardí, Mercè; Fukada, So-ichiro; Serrano, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Elsevier, 2015)
    Preservation of cell identity is necessary for homeostasis of most adult tissues. This process is challenged every time a tissue undergoes regeneration after stress or injury. In the lethal Duchenne muscular dystrophy ...
  • Bouché, Marina; Muñoz Cánoves, Pura, 1962-; Rossi, Fabio; Coletti, Dario (Hindawi, 2014)
  • Muñoz Cánoves, Pura, 1962-; Scheele, Camilla; Pedersen, Bente K.; Serrano, Antonio L. (Wiley, 2013)
    Interleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. ...
  • Testoni, Giorgia; Duran, Jordi; García-Rocha, Mar; Vilaplana, Francisco; Serrano, Antonio L.; Sebastián, David; López Soldado, Iliana; Sullivan, Mitchell A.; Slebe Concha, Juan Felipe, 1981-; Vilaseca, Marta; Muñoz Cánoves, Pura, 1962-; Guinovart, Joan J. (Joan Josep), 1947- (Elsevier, 2017)
    Glycogenin is considered essential for glycogen synthesis, as it acts as a primer for the initiation of the polysaccharide chain. Against expectations, glycogenin-deficient mice (Gyg KO) accumulate high amounts of glycogen ...
  • Kharraz, Yacine; Guerra, Joan; Mann, Christopher J.; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Hindawi, 2013)
    Effective repair of damaged tissues and organs requires the coordinated action of several cell types, including infiltrating inflammatory cells and resident cells. Recent findings have uncovered a central role for macrophages ...
  • Medici, Damian; Muñoz Cánoves, Pura, 1962-; Yang, Pan-Chyr; Brunelli, Silvia (Hindawi, 2016)
  • Baar, Marjolein P.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962-; de Keizer, Peter LJ (Elsevier, 2018)
    Aging is the prime risk factor for the broad-based development of diseases. Frailty is a phenotypical hallmark of aging and is often used to assess whether the predicted benefits of a therapy outweigh the risks for older ...
  • Pessina, Patrizia; Cabrera, Daniel; Morales, María Gabriela; Riquelme, Cecilia A; Gutiérrez, Jaime; Serrano, Antonio L.; Brandan, Enrique; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2014)
    Background: Fibrosis, an excessive collagen accumulation, results in scar formation, impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies, including the lethal Duchenne muscular ...
  • José Segarra-Martínez, Anabel (Universitat Pompeu Fabra, 2011-12-13)
    Els tractaments actuals pel càncer de pàncreas presenten un eficàcia limitada de manera que es necessari el desenvolupament de noves teràpies antitumorals. La teràpia gènica pel càncer de pàncreas basada en l’ús d’adenovirus ...