Welcome to the UPF Digital Repository

Browsing by Author "Mendoza, Manuel (Mendoza Palomares)"

Browsing by Author "Mendoza, Manuel (Mendoza Palomares)"

Sort by: Order: Results:

  • A midzone-based ruler adjusts chromosome compaction to analphase spindle length
    Neurohr, Gabriel Erich (Universitat Pompeu Fabra, 2012-04-13)
    Partitioning of chromatids during mitosis requires that chromosome compaction and spindle length scale appropriately with each other. However, it is not clear whether chromosome condensation and spindle elongation are linked. ...
  • Budding yeast complete DNA synthesis after chromosome segregation begins
    Ivanova, Tsvetomira Georgieva, 1978-; Maier, Michael, 1983-; Missarova, Alsu, 1990-; Ziegler-Birling, Céline; Dam, Monica; Gomar-Alba, Mercè; Carey, Lucas, 1980-; Mendoza, Manuel (Mendoza Palomares) (Nature Research, 2020)
    To faithfully transmit genetic information, cells must replicate their entire genome before division. This is thought to be ensured by the temporal separation of replication and chromosome segregation. Here we show that ...
  • High levels of histones promote whole-genome-duplications and trigger a Swe1(WEE1)-dependent phosphorylation of Cdc213(CDK1)
    Maya Miles, Douglas; Peñate, Xenia; Sanmartín Olmo, Trinidad; Jourquin, Frederic; Muñoz Centeno, Maria Cruz; Mendoza, Manuel (Mendoza Palomares); Simon, Marie-Noelle; Chávez, Sebastián; Geli, Vincent (eLife, 2018)
    Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations ...
  • Impact of chromosome fusions on 3D genome organization and gene expression in budding yeast
    Di Stefano, Marco; Di Giovanni, Francesca, 1985-; Pozharskaia, Vasilia; Gomar-Alba, Mercè; Baù, Davide; Carey, Lucas, 1980-; Marti-Renom, Marc A.; Mendoza, Manuel (Mendoza Palomares) (Genetics Society of America, 2020)
    The three-dimensional (3D) organization of chromosomes can influence transcription. However, the frequency and magnitude of these effects remain debated. To determine how changes in chromosome positioning affect transcription ...
  • The Aurora B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress
    Amaral, Nuno (Universitat Pompeu Fabra, 2017-06-02)
    La coordinació de la citocinesis amb la segregació cromosòmica és essencial per mantenir l’estabilitat cromosòmica durant la proliferació cel•lular. Tant en llevat com en cèl•lules animals, els ponts de cromatina en anafase ...
  • The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress
    Amaral, Nuno, 1984-; Vendrell Arasa, Alexandre; Funaya, Charlotta; Idrissi, Fatima-Zahra; Maier, Michael, 1983-; Kumar, Arun; Neurohr, Gabriel Erich; Colomina, Neus; Torres Rosell, Jordi; Geli, María-Isabel; Mendoza, Manuel (Mendoza Palomares) (Nature Publishing Group, 2016)
    Anaphase chromatin bridges can lead to chromosome breakage if not properly resolved before completion of cytokinesis. The NoCut checkpoint, which depends on Aurora B at the spindle midzone, delays abscission in response ...
  • Topoisomerase II and dynamic microtubules solve sister chromatid intertwinings in anaphase
    Titos Vivancos, Iris, 1986- (Universitat Pompeu Fabra, 2013-10-25)
    At the metaphase-to-anaphase transition, spindle microtubules pull replicated chromosomes to the daughter cells, but full separation of long chromosome arms is achieved in late anaphase. We have created an allelic series ...