Browsing by Author "Malhotra, Vivek"

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  • Cruz-Garcia, David; Brouwers, Nathalie; Duran, Juan M.; Mora, Gabriel; Curwin, Amy; Malhotra, Vivek (Rockefeller University Press, 2017)
    The nutrient starvation-specific unconventional secretion of Acb1 in Saccharomyces cerevisiae requires ESCRT-I, -II, and -III and Grh1. In this study, we report that another signal sequence lacking cytoplasmic protein, ...
  • Bunel, Louis; Pincet, Lancelot; Malhotra, Vivek; Raote, Ishier; Pincet, Frederic (National Academy of Sciences, 2024)
    Newly synthesized secretory proteins are exported from the endoplasmic reticulum (ER) at specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too large for export by the standard COPII-coated ...
  • Raote, Ishier; Chabanon, Morgan; Walani, Nikhil; Arroyo, Marino; Garcia-Parajo, Maria F.; Malhotra, Vivek; Campelo, Felix (eLife, 2020)
    The endoplasmic reticulum (ER)-resident protein TANGO1 assembles into a ring around ER exit sites (ERES), and links procollagens in the ER lumen to COPII machinery, tethers, and ER-Golgi intermediate compartment (ERGIC) ...
  • Blume, Julia von; Alleaume, Anne-Marie; Cantero Recasens, Gerard, 1984-; Curwin, Amy; Carreras Sureda, Amado, 1986-; Zimmermann, Timo; Galen, Josse van; Wakana, Yuichi; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (Elsevier, 2011)
    Actin-severing proteins ADF/cofilin are required for the sorting of secretory cargo at the trans-Golgi network (TGN) in mammalian cells. How do these cytoplasmic proteins interact with the cargoes in the lumen of the TGN? ...
  • Lekszas, Caroline; Foresti, Ombretta; Raote, Ishier; Liedtke, Daniel; König, Eva Maria; Nanda, Indrajit; Vona, Barbara; Coster, Peter de; Cauwels, Rita; Malhotra, Vivek; Haaf, Thomas (eLife, 2020)
    The transport and Golgi organization 1 (TANGO1) proteins play pivotal roles in the secretory pathway. Full length TANGO1 is a transmembrane protein localised at endoplasmic reticulum (ER) exit sites, where it binds bulky ...
  • Blume, Julia von; Alleaume, Anne-Marie; Kienzle, Christine; Carreras Sureda, Amado, 1986-; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (Rockefeller University Press, 2012)
    Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is ...
  • Curwin, Amy; Blume, Julia von; Malhotra, Vivek (American Society for Cell Biology, 2012)
    The mechanism of cargo sorting at the trans-Golgi network (TGN) for secretion is poorly understood. We previously reported the involvement of the actin-severing protein cofilin and the Ca(2+) ATPase secretory pathway calcium ...
  • Lujan, Agustin Leonardo; Foresti, Ombretta; Sugden, Conor; Brouwers, Nathalie; Farre, Alex Mateo; Vignoli, Alessio; Azamian, Mahshid; Turner, Alicia; Wojnacki, José; Malhotra, Vivek (eLife, 2023)
    We show that TANGO2 in mammalian cells localizes predominantly to mitochondria and partially at mitochondria sites juxtaposed to lipid droplets (LDs) and the endoplasmic reticulum. HepG2 cells and fibroblasts of patients ...
  • Burballa Tàrrega, Carla (2021-06-02)
    Dent disease 1 (DD1) is a rare renal tubulopathy caused by CLCN5 mutations and characterized by low molecular weight proteinuria, variable hypercalciuria, nephrocalcinosis and/or nephrolithiasis and progression to kidney ...
  • Chiritoiu, Marioara; Stewart, Sarah E.; Zhang, Min; Malhotra, Vivek; Villeneuve, Julien (Frontiers, 2022)
  • Curwin, Amy; Brouwers, Nathalie; Alonso Y Adell, Manuel; Teis, David; Turacchio, Gabriele; Parashuraman, Seetharaman; Ronchi, Paolo; Malhotra, Vivek (eLife, 2016)
    The unconventional secretory pathway exports proteins that bypass the endoplasmic reticulum. In Saccharomyces cerevisiae, conditions that trigger Acb1 secretion via this pathway generate a Grh1 containing compartment ...
  • Chiritoiu, Marioara; Brouwers, Nathalie; Turacchio, Gabriele; Pirozzi, Marianella; Malhotra, Vivek (Elsevier, 2019)
    Signal-sequence-lacking interleukin (IL)-1β, is cleaved by caspase-1 to mature mIL-1β, which is secreted, without entering the endoplasmic reticulum. We report that macrophages of GRASP55-/- mice are defective in mIL-1β ...
  • Bruns, Caroline (Universitat Pompeu Fabra, 2013-11-05)
    A part de la secreció convencional, en la qual les proteïnes són transportades a través del reticle endoplasmàtic (RE) i de l'aparell de Golgi, s'han descrit, per a diferents proteïnes i en organismes diversos, rutes de ...
  • Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Valverde, M. A. (Miguel Ángel), 1963-; Naranjo, José R.; Brouwers, Nathalie; Malhotra, Vivek (eLife, 2018)
    Regulated mucin secretion from specialized goblet cells by exogenous agonist-dependent (stimulated) and -independent (baseline) manner is essential for the function of the epithelial lining. Over extended periods, baseline ...
  • Wakana, Yuichi; Villeneuve, Julien; Galen, Josse van; Cruz-Garcia, David; Tagaya, Mitsuo; Malhotra, Vivek (Rockefeller University Press, 2013)
    Here we report that the kinesin-5 motor Klp61F, which is known for its role in bipolar spindle formation in mitosis, is required for protein transport from the Golgi complex to the cell surface in Drosophila S2 cells. ...
  • Bassaganyas Bars, Laia, 1985-; Popa, Stephanie J.; Horlbeck, Max; Puri, Claudia; Stewart, Sarah E.; Campelo, Felix; Ashok, Anupama, 1985-; Butnaru, Cristian M.; Brouwers, Nathalie; Heydari, Kartoosh; Ripoche, Jean; Weissman, Jonathan; Rubinsztein, David C.; Schekman, Randy; Malhotra, Vivek; Moreau, Kevin; Villeneuve, Julien (Rockefeller University Press, 2019)
    Protein and membrane trafficking pathways are critical for cell and tissue homeostasis. Traditional genetic and biochemical approaches have shed light on basic principles underlying these processes. However, the list of ...
  • Durán, Mónica; Burballa Tàrrega, Carla, 1988-; Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Malhotra, Vivek; Ariceta, Gema; Sarró, Eduard; Meseguer, Anna (Oxford University Press, 2021)
    Dent disease 1 (DD1) is a rare X-linked renal proximal tubulopathy characterized by low molecular weight proteinuria and variable degree of hypercalciuria, nephrocalcinosis and/or nephrolithiasis, progressing to chronic ...
  • Raote, Ishier; Malhotra, Vivek (Rockefeller University Press, 2019)
    Palade's corpus placed small vesicles as the sole means to transport proteins across stable distinct compartments of the secretory pathway. We suggest that cargo, spatial organization of secretory compartments, and the ...
  • Cruz-Garcia, David; Brouwers, Nathalie; Malhotra, Vivek; Curwin, Amy (Rockefeller University Press, 2020)
    Nutrient deprivation triggers the release of signal-sequence-lacking Acb1 and the antioxidant superoxide dismutase 1 (SOD1). We now report that secreted SOD1 is functionally active and accompanied by export of other ...
  • Cruz-Garcia, David; Curwin, Amy; Popoff, Jean-François; Bruns, Caroline, 1984-; Duran, Juan M.; Malhotra, Vivek (Rockefeller University Press, 2014)
    Upon starvation, Grh1, a peripheral membrane protein located at endoplasmic reticulum (ER) exit sites and early Golgi in Saccharomyces cerevisiae under growth conditions, relocates to a compartment called compartment for ...

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