Visualitza per autoria "López Muñoz, Laura"

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  • A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer
    Margalef González, Pol, 1985-; Fernández Majada, Vanessa; Villanueva, Alberto; Garcia Carbonell, Ricard; Iglesias Coma, Mar; López Muñoz, Laura; Martínez Iniesta, María; Villà i Freixa, Jordi; Mulero, María Carmen; Andreu García, Montserrat; Torres, Ferran; Mayo, Marty W.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2012)
    Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and IKKα activity remains ...
  • Homology modeling and structural analysis of the antipsychotic drugs receptorome
    López Muñoz, Laura (Universitat Pompeu Fabra, 2011-04-12)
    Classically it was assumed that the compounds with therapeutic effect exert their action interacting with a single receptor. Nowadays it is widely recognized that the pharmacological effect of most drugs is more complex ...
  • Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta (2) adrenergic receptor template
    López Muñoz, Laura; Pastor Maeso, Manuel; Sanz, Ferran; Selent, Jana (Wiley-Blackwell, 2008)
    Schizophrenia is a devastating mental disorder that has a large/nimpact on the quality of life for those who are afflicted and is/nvery costly for families and society.[1] Although the etiology of/nschizophrenia is still ...
  • PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation
    Rodríguez, María Isabel; Peralta-Leal, Andreína; O'Valle, Francisco; Rodríguez-Vargas, José Manuel; González-Flores, Ariannys; Majuelos-Melguizo, Jara; López Muñoz, Laura; Serrano, Santiago; García de Herreros, Antonio; Rodríguez-Manzaneque, Juan Carlos; Fernández Montes, Rubén D.; del Moral, Raimundo G.; de Almodovar, José Mariano; Oliver, F. Javier (Public Library of Science (PLoS), 2013)
    PARP inhibition can induce anti-neoplastic effects when used as monotherapy or in combination with chemo- or radiotherapy in various tumor settings; however, the basis for the anti-metastasic activities resulting from PARP ...
  • Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands
    López Muñoz, Laura; Sanz, Ferran; Pastor Maeso, Manuel; Selent, Jana; Loza, María I.; Brea, José; Areias, Filipe; Ortega, Raquel; Masaguer, Christian F.; Raviña, Enrique (Elsevier, 2009)
    A series of new benzolactam derivatives was synthesized and the derivatives were evaluated for their/naffinities at the dopamine D1, D2, and D3 receptors. Some of these compounds showed high D2 and/or/nD3 affinity and ...
  • Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivative as pontential antipsychotics
    López Muñoz, Laura; Aranda, Reyes; Villalba, Karen; Raviña, Enrique; Masaguer, Christian F.; Brea, José; Areias, Filipe; Domínguez, Eduardo; Selent, Jana; Sanz, Ferran; Loza, María I.; Pastor Maeso, Manuel (American Chemical Society (ACS), 2008)
    The complex etiology of schizophrenia has prompted researchers to develop clozapine-related multitarget/nstrategies to combat its symptoms. Here we describe a series of new 6-aminomethylbenzofuranones in an/neffort to find ...

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