Visualitza per autor "López Bigas, Núria"

Ordena per: Ordre: Resultats:

  • Iorio, Francesco Iorio; Tamborero Noguera, David; López Bigas, Núria; Esteller, Manel; Garnett, Mathew J. (Elsevier, 2016)
    Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is challenging. Here, ...
  • Frigola, Joan; Iturbide, Ane; López Bigas, Núria; Peiró Sales, Sandra; González-Pérez, Abel (Impact Journals, 2016)
    Chromatin regulatory factors (CRFs), are known to be involved in tumorigenesis in several cancer types. Nevertheless, the molecular mechanisms through which driver alterations of CRFs cause tumorigenesis remain unknown. ...
  • Mascarell Creus, Albert; López Bigas, Núria; Caño Delgado, Ana I. (BioMed Central, 2009)
    Background: Melon (Cucumis melo) is a horticultural specie of significant nutritional value, which belongs to the Cucurbitaceae family, whose economic importance is second only to the Solanaceae. Its small genome of approx. ...
  • Schroeder, Michael Philipp, 1986- (Universitat Pompeu Fabra, 2014-11-21)
    Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation of cancer genomics ...
  • Hernando, Henar; Shannon Lowe, Claire; Islam, Abul, 1978-; Al-Shahrour, Fátima; Rodríguez Ubreva, Javier; Rodríguez Cortez, Virginia C; Javierre, Biola M; Mangas, Cristina; Fernández, Agustín F; Parra, Maribel; Delecluse, Henri Jacques; Esteller, Manel; López Granados, Eduardo; Fraga, Mario F; López Bigas, Núria; Ballestar, Esteban (BioMed Central, 2013)
    Background: Epstein-Barr virus (EBV) infection is a well characterized etiopathogenic factor for a variety of immune-related conditions, including lymphomas, lymphoproliferative disorders and autoimmune diseases. EBV-mediated ...
  • Guberman, Jonathan M.; Gundem, Gunes; López Bigas, Núria; Pérez Llamas, Christian, 1976-; Kasprzyk, Arek (Oxford University Press, 2011)
    BioMart Central Portal is a first of its kind, community-driven effort to provide unified access to dozens of biological databases spanning genomics, proteomics, model organisms, cancer data, ontology information and more. ...
  • Barneda Zahonero, Bruna; Román González, Lidia; Collazo, Olga; Rafati, Haleh; Islam, Abul, 1978-; Bussmann, Lars; Di Tullio, Alessandro, 1982-; Andrés, Luisa De; Graf, T. (Thomas); López Bigas, Núria; Mahmoudi, Tokameh; Parra, Maribel (Universitat Pompeu Fabra, 2013-05)
    HDAC7 is a repressor of myeloid genes whose downregulation in pre-B cells is required for transdifferentiation into macrophages.
  • Tamborero Noguera, David; Rubio Pérez, Carlota; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets, Ignasi; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Dienstmann, Rodrigo; González-Pérez, Abel; López Bigas, Núria (Universitat Pompeu Fabra, 2016-10-17)
    The cancer bioMarkers database is curated and maintained by several clinical and scientific experts in the field of precision oncology supported by the European Union’s Horizon 2020 funding. This database is currently being ...
  • Furney, Simon J.; Madden, Stephen F.; Kisiel, Tomasz A.; Higgins, Desmond G.; López Bigas, Núria (Universitat Pompeu Fabra, 2007-12)
    Cancer gene properties.
  • Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Vona, Chiara Di; Bezdan, Daniela; Islam, Abul, 1978-; Salichs Fradera, Eulàlia; López Bigas, Núria; Ossowski, Stephan; Luna, Susana de la (Elsevier, 2015)
    DYRK1A is a dosage-sensitive protein kinase that fulfills key roles during development and in tissue homeostasis, and its dysregulation results in human pathologies. DYRK1A is present in both the nucleus and cytoplasm of ...
  • Islam, Abul, 1978-; Richter, William F.; Jacobs, Laura A.; López Bigas, Núria; Benevolenskaya, Elizaveta V. (Public Library of Science (PLoS), 2011)
    Cancer is characterized by aberrant patterns of expression of multiple genes. These major shifts in gene expression are believed to be due to not only genetic but also epigenetic changes. The epigenetic changes are ...
  • Tamborero Noguera, David; González-Pérez, Abel; Pérez Llamas, Christian, 1976-; Déu Pons, Jordi; Kandoth, Cyriac; Reimand, Jüri; Lawrence, Michael S.; Getz, Gad; Bader, Gary D.; Ding, Li; López Bigas, Núria (Nature Publishing Group, 2013)
    With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous ...
  • Pérez Llamas, Christian, 1976- (Universitat Pompeu Fabra, 2015-12-18)
    Given the complexity and heterogeneity of cancer, the/ndevelopment of new high-throughput wide-genome technologies/nhas open new possibilities for its study. Several projects around the/nglobe are exploiting these technologies ...
  • Gundem, Gunes (Universitat Pompeu Fabra, 2011-09-29)
    In my thesis, I focused on integrative analysis of high-throughput oncogenomic data. This was done in two parts: In the first part, I describe IntOGen, an integrative data mining tool for the study of cancer. This system ...
  • Nicolay, Brandon N.; Bayarmagnai, Battuya; Islam, Abul, 1978-; López Bigas, Núria; Frolov, Maxim V. (Cold Spring Harbor Laboratory Press (CSHL Press), 2011)
    The Hippo signaling pathway regulates organ size homeostasis, while its inactivation leads to severe hyperplasia in flies and mammals. The transcriptional coactivator Yorkie (Yki) mediates transcriptional output of the ...
  • Gallardo Hernández, Fernando; Padrón, Andreina; Garcia Carbonell, Ricard; Rius, Cristina; González-Pérez, Abel; Arumí, Montserrat; Iglesias Coma, Mar; Nonell Mazelón, Lara; Bellosillo Paricio, Beatriz; Segura Tigell, Sonia; Pujol Vallverdú, Ramon Maria; López Bigas, Núria; Bertran, Joan; Bigas Salvans, Anna; Espinosa Blay, Lluís (Impact Journal, 2015)
    Invasive malignant melanoma (MM) is an aggressive tumor with no curative therapy available in advanced stages. Nuclear corepressor (NCoR) is an essential regulator of gene transcription, and its function has been found ...
  • Islam, Abul, 1978- (Universitat Pompeu Fabra, 2012-06-25)
    Recent advances in high throughput technology have opened the door to systematic studies of epigenetic mechanisms. One of the key components in the regulation of the cell cycle and differentiation is the retinoblastoma ...
  • Furney, Simon J.; Albà Soler, Mar; López Bigas, Núria (BioMed Central, 2006)
    Background: Global analyses of human disease genes by computational methods have yielded important advances in the understanding of human diseases. Generally these studies have treated the group of disease genes uniformly, ...
  • López Bigas, Núria; De, Subhajyoti; Teichmann, Sarah A. (Universitat Pompeu Fabra, 2007-10)
    Mutations, genes and pathways involved in tumorigenesis across 4,623 cancer genomes/exomes from 13 cancer sites. IntOGen-mutations identifies cancer drivers across tumor types. Nature Methods 10, 2013, doi:10.1038/nmeth.2642