Browsing by Author "Elosua Llanos, Roberto"

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  • Rodrigo, Emilio; Pich, Sara; Subirana Cachinero, Isaac; Fernandez-Fresnedo, Gema; Barreda, Paloma; Ferrer-Costa, Carles; de Francisco, Angel Luis M.; Salas, Eduardo; Elosua Llanos, Roberto; Arias, Manuel (Oxford University Press, 2017)
    BACKGROUND: Coronary heart disease (CHD) is the primary cause of death in individuals with chronic kidney disease (CKD), but current equations for assessing coronary risk have low accuracy in this group. We have reported ...
  • Dégano, Irene R.; Subirana Cachinero, Isaac; Torre, Marina; Grau Magaña, Maria; Vila, Joan; Fusco, Danilo; Kirchberger, Inge; Ferrières, Jean; Malmivaara, Antti; Azevedo, Ana; Meisinger, Christa; Bongard, Vanina; Farmakis, Dimitrios; Davoli, Marina; Häkkinen, Unto; Araújo, Carla; Lekakis, John; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume (Elsevier, 2015)
    BACKGROUND: Hospital performance models in acute myocardial infarction (AMI) are useful to assess patient management. While models are available for individual countries, mainly US, cross-European performance models are ...
  • Musameh, Muntaser D.; Wang, William Y. S.; Nelson, Christopher P.; Lluís Ganella, Carla, 1984-; Debiec, Radoslaw; Subirana Cachinero, Isaac; Elosua Llanos, Roberto; Balmforth, Anthony J.; Ball, Stephen G.; Hall, Alistair S.; Kathiresan, Sekar; Thompson, John R.; Lucas, Gavin, 1977-; Samani, Nilesh J.; Tomaszewski, Maciej (Public Library of Science, 2015)
    OBJECTIVE: Only a small fraction of coronary artery disease (CAD) heritability has been explained by common variants identified to date. Interactions between genes of importance to cardiovascular regulation may account for ...
  • Emdin, Connor A.; Elosua Llanos, Roberto; Kathiresan, Sekar (Nature Research, 2018)
    Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted ...
  • Lek, Monkol; Elosua Llanos, Roberto; MacArthur, Daniel G.; Exome Aggregation Consortium (Macmillan Publishers, 2016)
    Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis of high-quality exome (protein-coding ...
  • Baena Díez, Jose M.; Garcia Gil, Maria; Comas Cufí, Marc; Ramos, Rafel; Prieto-Alhambra, Daniel; Salvador-González, Betlem; Elosua Llanos, Roberto; Dégano, Irene R.; Peñafiel Muñoz, Judith; Grau Magaña, Maria (BMJ Publishing Group, 2017)
  • Schröder, Helmut, 1958-; Serra-Majem, Luis; Subirana Cachinero, Isaac; Izquierdo Pulido, Maria; Fitó Colomer, Montserrat; Elosua Llanos, Roberto (Cambridge University Press, 2016)
    Higher monetary diet cost is associated with healthier food choices and better weight management. How changes in diet cost affect changes in diet quality and weight remains unknown. The aim of this study was to assess the ...
  • Foraster Pulido, Maria, 1984-; Basagaña Flores, Xavier; Aguilera Jiménez, Inmaculada, 1977-; Rivera, Marcela, 1982-; Agis, David; Bouso, Laura; Deltell, Alexandre; Marrugat de la Iglesia, Jaume; Ramos, Rafel; Sunyer Deu, Jordi; Vila, Joan; Elosua Llanos, Roberto; Künzli, Nino (National Institute of Environmental Health Sciences (NIEHS), 2014)
    Background: Long-term exposure to traffic-related air pollution may increase blood pressure (BP) and induce hypertension. However, evidence supporting these associations is limited, and they may be confounded by exposure ...
  • Serra, Guillem; Baranchuk, Adrian; Bayés-De-Luna, Antoni; Brugada, Josep; Goldwasser, Diego; Capulzini, Lucio; Arazo, David; Boraita, Araceli; Heras, Maria-Eugenia; Garcia-Niebla, Javier; Elosua Llanos, Roberto; Brugada, Ramón; Brugada, Pedro (Oxford University Press, 2015)
  • Elosua Llanos, Roberto; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin, 1977-; Sayols, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí Clapés, Mariano; Siscovick, David; Mellander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat de la Iglesia, Jaume (Lippincott Williams & Wilkins, 2016)
    BACKGROUND: Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk ...
  • Emdin, Connor A.; Elosua Llanos, Roberto; Kathiresan, Sekar (American Diabetes Association, 2019)
    A genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI), a measure of body fat distribution, associates with increased risk for type 2 diabetes. We conducted an exome-wide association study of ...
  • Pattaro, Cristian; Friedrich, Nele; Elosua Llanos, Roberto; Lucas, Gavin, 1977- (Nature Publishing Group, 2016)
    Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ...
  • Lluís Ganella, Carla, 1984- (Universitat Pompeu Fabra, 2012-06-26)
    The main expansion of the discovery of genetic variants associated with complex diseases has occurred during the last decade. This expansion has been accompanied, and in some sense motivated, by the desire to use this ...
  • Lucas, Gavin, 1977-; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Musameh, Muntaser D.; González Ruiz, Juan Ramón; Nelson, Christopher P.; Sentí Clapés, Mariano; Myocardial Infarction Genetics; Wellcome Trust Case Control Constortium; Schwartz, Stephen M; Siscovick, David; O'Donnell, Christopher J; Melander, Olle; Salomaa, Veikko; Purcell, Shaun; Altshuler, David; Samani, Nilesh J.; Kathiresan, Sekar; Elosua Llanos, Roberto (Public Library of Science (PLoS), 2012)
    The genetic loci that have been found by genome-wide association studies to modulate risk of coronary heart disease explain only a fraction of its total variance, and gene-gene interactions have been proposed as a potential ...
  • Sayols, Sergi; Subirana Cachinero, Isaac; Lluís Ganella, Carla, 1984-; Civeira, F.; Roquer, Jaume; Do, AN; Absher, Devin; Cenarro, A.; Muñoz, Dani; Soriano Tarraga, Carolina; Jiménez Conde, Jordi; Ordovás, José M.; Sentí Clapés, Mariano; Aslibekyan, Stella; Marrugat de la Iglesia, Jaume; Arnett, D.K.; Elosua Llanos, Roberto (Oxford University Press, 2016)
    Lipid traits (total, low-densityand high-density lipoproteincholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is an inherited but also modifiable epigenetic mark ...
  • Sayols, Sergi; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Salas, Lucas A.; Vilahur Chiaraviglio, Nadia, 1982-; Corella, Dolores; Muñoz, Dani; Segura, Antoni, 1952-; Jiménez Conde, Jordi; Moran, Sebastian; Soriano Tarraga, Carolina; Roquer, Jaume; Lopez-Farré, Antonio; Marrugat de la Iglesia, Jaume; Fitó Colomer, Montserrat; Elosua Llanos, Roberto (Taylor & Francis, 2015)
    Smoking increases the risk of many diseases and could act through changes in DNA methylation patterns. The aims of this study were to determine the association between smoking and DNA methylation throughout the genome at ...
  • Alonso, Nerea; Garcia Giralt, Natàlia; Lucas, Gavin, 1977-; Elosua Llanos, Roberto; Ralston, Stuar (BMJ Publishing Group, 2018)
    OBJECTIVES: To identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis. METHODS: Here we conduct a genome-wide association study in 1553 postmenopausal ...
  • García-García, Cosme; Ribas Barquet, Núria; Recasens, Lluís; Meroño, Oona; Subirana Cachinero, Isaac; Fernández, A.; Pérez, Ana; Miranda, F.; Tizón-Marcos, H.; Martí-Almor, Julio; Bruguera-Cortada, Jordi; Elosua Llanos, Roberto (BioMed Central, 2017)
    BACKGROUND: ST Segment Elevation Acute myocardial infarction (STEMI) preferred treatment is culprit artery reperfusion with primary percutaneous coronary intervention (PPCI). We ought to analyze the benefit of early ...
  • Pimienta González, Raquel; Couto Comba, Patricia; Rodríguez Esteban, Marcos; Alemán Sánchez, José Juan; Hernández Afonso, Julio; Rodríguez Pérez, María del Cristo; Marcelino Rodríguez, Itahisa; Brito Díaz, Buenaventura; Elosua Llanos, Roberto; Cabrera de León, Antonio (Public Library of Science (PLoS), 2016)
    OBJECTIVES: To determine whether the risk of cardiovascular mortality associated with cardiorenal syndrome subtype 1 (CRS1) in patients who were hospitalized for acute coronary syndrome (ACS) was greater than the expected ...
  • Lacalzada-Almeida, Juan; Izquierdo-Gómez, María Manuela; Belleyo-Belkasem, Carima; Barrio-Martínez, Patricia; García-Niebla, Javier; Elosua Llanos, Roberto; Jiménez-Sosa, Alejandro; Escobar-Robledo, Luis Alberto; Bayés-De-Luna, Antoni (BioMed Central, 2018)
    BACKGROUND: To evaluate the possibility of left atrial (LA) remodeling using speckle tracking echocardiography (STE) in patients with interatrial block (IAB). METHODS: We performed a cross-sectional study with three groups ...