Visualitza per autoria "Chiva, Cristina"

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  • Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer's disease cerebrospinal fluid
    Lleó, Alberto; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981-; Belbin, Olivia (Elsevier, 2019)
    A biomarker of synapse loss, an early event in Alzheimer's disease (AD) pathophysiology that precedes neuronal death and symptom onset, would be a much-needed prognostic biomarker. With direct access to the brain interstitial ...
  • Dataset of the Botrytis cinerea phosphoproteome induced by different plant-based elicitors
    Liñeiro, Eva; Chiva, Cristina; Cantoral Fernández, Jesús M.; Sabidó Aguadé, Eduard, 1981-; Fernández-Acero, Francisco Javier (Elsevier, 2016)
    Phosphorylation is one of the main post-translational modification (PTM) involved in signaling network in the ascomycete Botrytis cinerea, one of the most relevant phytopathogenic fungus. The data presented in this article ...
  • Evaluation of different peptide fragmentation types and mass analyzers in data-dependent methods using an Orbitrap Fusion Lumos Tribrid mass spectrometer
    Espadas, Guadalupe; Borràs, Eva; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981- (Wiley, 2017)
    One of the major additions in MS technology has been the irruption of the Orbitrap mass analyzer, which has boosted the proteomics analyses of biological complex samples since its introduction. Here, we took advantage of ...
  • Isotopologue multipoint calibration for proteomics biomarker quantification in clinical practice
    Chiva, Cristina; Pastor, Olga; Trilla Fuertes, Lucía; Gámez Pozo, Angelo; Fresno Vara, Juan Ángel; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2019)
    Targeted proteomics has become the method of choice for biomarker validation in human biopsies due to its high sensitivity, reproducibility, accuracy, and precision. However, for targeted proteomics to be transferred to ...
  • MassIVE.quant: a community resource of quantitative mass spectrometry-based proteomics datasets
    Choi, Meena; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981-; Vitek, Olga (Nature Research, 2020)
    MassIVE.quant is a repository infrastructure and data resource for reproducible quantitative mass spectrometry-based proteomics, which is compatible with all mass spectrometry data acquisition types and computational ...
  • Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis
    Colomé, Núria; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981-; EuPA (Elsevier, 2022)
    Global analysis of protein phosphorylation by mass spectrometry proteomic techniques has emerged in the last decades as a powerful tool in biological and biomedical research. However, there are several factors that make ...
  • Multicenter experiment for quality control of peptide-centric LC-MS/MS analysis - A longitudinal performance assessment with nLC coupled to orbitrap MS analyzers
    Campos, Alex; Díaz, Ramón; Martínez Bartolomé, Salvador; Sierra, Jose; Gallardo, Oscar; Sabidó Aguadé, Eduard, 1981-; López Lucendo, María; Casal, José Ignacio; Pasquarello, Carla; Scherl, Alexander; Chiva, Cristina; Borrás, Eva; Odena, Antonia; Elortza, Félix; Azkargorta, Mikel; Ibarrola, Nieves; Canals, Francesc; Albar, Juan Pablo; Oliveira, Eliandre (Elsevier, 2015)
    Proteomic technologies based on mass spectrometry (MS) have greatly evolved in the past years, and nowadays it is possible to routinely identify thousands of peptides from complex biological samples in a single LC-MS/MS ...
  • Origins of de novo genes in human and chimpanzee
    Ruiz Orera, Jorge, 1988-; Hernández Rodríguez, Jéssica, 1983-; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981-; Kondova, Ivanela; Bontrop, Ronald E.; Marquès i Bonet, Tomàs, 1975-; Albà Soler, Mar (Public Library of Science, 2015)
    The birth of new genes is an important motor of evolutionary innovation. Whereas many new genes arise by gene duplication, others originate at genomic regions that did not contain any genes or gene copies. Some of these ...
  • Peptide selection for targeted protein quantitation
    Chiva, Cristina; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2017)
    Targeted proteomics methods in their different flavors rely on the use of a few peptides as proxies for protein quantitation, which need to be specified either prior to or after data acquisition. However, in contrast with ...
  • Prediction of adjuvant chemotherapy response in triple negative breast cancer with discovery and targeted proteomics
    Gámez Pozo, Angelo; Trilla Fuertes, Lucía; Prado Vázquez, Guillermo; Chiva, Cristina; López Vacas, Rocío; Nanni, Paolo; Berges Soria, Julia; Grossmann, Jonas; Díaz Almirón, Mariana; Ciruelos, Eva; Sabidó Aguadé, Eduard, 1981-; Espinosa Arranz, Enrique; Fresno Vara, Juan Ángel (Public Library of Science (PLoS), 2017)
    BACKGROUND: Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast cancers and usually requires the administration of adjuvant chemotherapy after surgery but even with this treatment many patients still ...
  • Profiling the secretome and extracellular proteome of the potato late blight pathogen phytophthora infestans
    Meijer, Harold J. G.; Mancuso, Francesco M.; Espadas, Guadalupe; Seidl, Michael F.; Chiva, Cristina; Govers, Francine; Sabidó Aguadé, Eduard, 1981- (American Society for Biochemistry and Molecular Biology (ASBMB), 2014)
    Oomycetes are filamentous organisms that cause notorious diseases, several of which have a high economic impact. Well known is Phytophthora infestans, the causal agent of potato late blight. Previously, in silico analyses ...
  • Protein-based classifier to predict conversion from clinically isolated syndrome to multiple sclerosis
    Borrás, Eva; Cantó, Ester; Choi, Meena; Villar, Luisa Maria; Álvarez Cermeño, Jose Carlos; Chiva, Cristina; Montalbán Gairín, Xavier; Vitek, Olga; Comabella López, Manuel; Sabidó Aguadé, Eduard, 1981- (American Society for Biochemistry and Molecular Biology (ASBMB), 2016)
    Multiple sclerosis is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system. In most patients, the disease initiates with an episode of neurological disturbance referred to as clinically ...
  • Proteomic study of the membrane components of signalling cascades of Botrytis cinerea controlled by phosphorylation
    Escobar-Niño, Almudena; Liñeiro, Eva; Amil, Francisco; Carrasco, Raphaël, 1950-; Chiva, Cristina; Fuentes, Carlos; Blanco-Ulate, Barbara; Cantoral Fernández, Jesús M.; Sabidó Aguadé, Eduard, 1981-; Fernández-Acero, Francisco Javier (Nature Research, 2019)
    Protein phosphorylation and membrane proteins play an important role in the infection of plants by phytopathogenic fungi, given their involvement in signal transduction cascades. Botrytis cinerea is a well-studied necrotrophic ...
  • Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer
    Rojas Laimito, Katerin; Trilla Fuertes, Lucía; Gámez Pozo, Angelo; Chiva, Cristina; Sepúlveda, Juan M.; Manso, Luis; Prado Vázquez, Guillermo; Zapater-Moros, Andrea; López Vacas, Rocío; Ferrer-Gómez, María; Mendiola, César; Espinosa Arranz, Enrique; Sabidó Aguadé, Eduard, 1981-; Ciruelos, Eva; Fresno Vara, Juan Ángel (Cancer Intelligence, 2019)
    Background: Breast cancer (BC) is the most frequent tumour in women. Triple negative tumours (TNBC)–which are associated with minor survival rates—lack markers predictive of response to anticancer drugs. Triple negative ...
  • QCloud2: an improved cloud-based quality-control system for mass-spectrometry-based proteomics laboratories
    Olivella, Roger; Chiva, Cristina; Serret, Marc; Mancera, Daniel; Cozzuto, Luca; Hermoso Pulido, Antonio; Borràs, Eva; Espadas, Guadalupe; Morales Sanfrutos, Julia; Pastor, Olga; Solé, Amanda; Ponomarenko, Julia; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2021)
    QCloud is a cloud-based system to support proteomics laboratories in daily quality assessment using a user-friendly interface, easy setup, and automated data processing. Since its release, QCloud has facilitated automated ...
  • QCloud: a cloud-based quality control system for mass spectrometry-based proteomics laboratories
    Chiva, Cristina; Olivella, Roger; Borràs, Eva; Espadas, Guadalupe; Pastor, Olga; Solé, Amanda; Sabidó Aguadé, Eduard, 1981- (Public Library of Science (PLoS), 2018)
    The increasing number of biomedical and translational applications in mass spectrometry-based proteomics poses new analytical challenges and raises the need for automated quality control systems. Despite previous efforts ...
  • Quality standards in proteomics research facilities: Common standards and quality procedures are essential for proteomics facilities and their users
    Chiva, Cristina; Mendes Maja, Teresa; Panse, Christian; Stejskal, Karel; Douché, Thibaut; Matondo, Mariette; Loew, Darmarys; Helm, Dominic; Rettel, Mandy; Mechtler, Karl; Impens, Francis; Nanni, Paolo; Shevchenko, Anna; Sabidó Aguadé, Eduard, 1981- (EMBO Press, 2021)
    Proteomics research infrastructures and core facilities within the Core for Life alliance advocate for community policies for quality control to ensure high standards in proteomics services.
  • Stepwise emergence of the neuronal gene expression program in early animal evolution
    Najle, Sebastián R.; Grau Bové, Xavier; Elek, Anamaria; Navarrete Hernández, Cristina; Cianferoni, Damiano; Chiva, Cristina; Cañas Armenteros, Didac; Mallabiabarrena, Arrate; Kamm, Kai; Sabidó Aguadé, Eduard, 1981-; Gruber-Vodicka, Harald; Schierwater, Bernd; Serrano Pubull, Luis, 1982-; Sebé-Pedrós, Arnau (Elsevier, 2023)
    The assembly of the neuronal and other major cell type programs occurred early in animal evolution. We can reconstruct this process by studying non-bilaterians like placozoans. These small disc-shaped animals not only have ...
  • The dental proteome of Homo antecessor
    Welker, Frido; Chiva, Cristina; Kuhlwilm, Martin; Manuel Montero, Marc de, 1991-; Gelabert Xirinachs, Pere, 1991-; Marquès i Bonet, Tomàs, 1975-; Sabidó Aguadé, Eduard, 1981-; Lalueza Fox, Carles, 1965-; Cappellini, Enrico (Nature Research, 2020)
    The phylogenetic relationships between hominins of the Early Pleistocene epoch in Eurasia, such as Homo antecessor, and hominins that appear later in the fossil record during the Middle Pleistocene epoch, such as Homo ...
  • The Dynamic Regulatory Genome of Capsaspora and the Origin of Animal Multicellularity
    Sebé-Pedrós, Arnau; Ballaré, Cecilia Julia; Parra-Acero, Helena; Chiva, Cristina; Tena, Juan J.; Sabidó Aguadé, Eduard, 1981-; Gómez Skarmeta, José Luis; Di Croce, Luciano; Ruíz Trillo, Iñaki (Elsevier, 2016)
    The unicellular ancestor of animals had a complex repertoire of genes linked to multicellular processes. This suggests that changes in the regulatory genome, rather than in gene innovation, were key to the origin of animals. ...

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