Visualitza per autoria "Carrato, Alfredo"

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  • Application of multi-SNP approaches Bayesian LASSO and AUC-RF to detect main effects of inflammatory-gene variants associated with bladder cancer risk
    López De Maturana, Evangelina; Ye, Yuanqing; Calle, M. Luz; Rothman, Nathaniel; Urrea, Víctor; Kogevinas, Manolis; Petrus, Sandra; Chanock, Stephen J.; Tardón, Adonina; García Closas, Montserrat; González Neira, Anna; Vellalta, Gemma; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Lorente-Galdós, Belén, 1981-; Silverman, Debra T.; Real, Francisco X.; Wu, Xifeng; Malats i Riera, Núria (Public Library of Science (PLoS), 2013)
    The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study between 886 inflammatory-gene variants and bladder cancer risk in ...
  • Bladder cancer and reproductive factors among women in Spain
    Huang, An-Tsun; Kogevinas, Manolis; Silverman, Debra T.; Malats i Riera, Núria; Rothman, Nathaniel; Tardón, Adonina; Serra, Consol; García Closas, Reina; Carrato, Alfredo; Cantor, Kenneth P (Springer, 2009)
    Hormonal factors, possibly related to reproductive characteristics, may play a role in the risk of bladder cancer among women. To study this, we investigated the effects of reproductive factors on female bladder cancer ...
  • Coffee consumption, genetic susceptibility and bladder cancer risk
    Villanueva, Cristina M.; Silverman, Debra T.; Murta-Nascimento, Cristiane; Malats i Riera, Núria; García Closas, Montserrat; Castro Domínguez, Francisco; Tardón, Adonina; García Closas, Reina; Serra, Consol; Carrato, Alfredo; Rothman, Nathaniel; Real, Francisco X.; Dosemeci, Mustafa; Kogevinas, Manolis (Springer, 2009)
    Objective: We evaluated the bladder cancer risk associated with coffee consumption in a case–control study in Spain and examined the gene–environment interactions for genetic variants of caffeine-metabolizing enzymes. ...
  • Consensus guidelines for diagnosis, treatment and follow-up of patients with pancreatic cancer in Spain
    Hidalgo, Manuel; Martinez, Alejandro; Carrato, Alfredo (Springer, 2017)
    The management of patients with pancreatic cancer has advanced over the last few years. We convey a multidisciplinary group of experts in an attempt to stablish practical guidelines for the diagnoses, staging and management ...
  • Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysis
    Czachorowski, Maciej J; Amaral, André F.S.; Montes-Moreno, Santiago; Lloreta Trull, Josep, 1958-; Carrato, Alfredo; Tardón, Adonina; Morente, Manuel M; Kogevinas, Manolis; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2012)
    Aberrant overexpression of cyclooxygenase-2 (COX2) is observed in urothelial carcinoma of the bladder (UCB). Studies evaluating COX2 as a prognostic marker in UCB report contradictory results. We determined the prognostic ...
  • Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1
    Herrera, Alberto; Herrera, Mercedes; Guerra-Perez, Natalia; Galindo-Pumariño, Cristina; Larriba, María Jesús; García-Barberán, Vanesa; Gil, Beatriz; Giménez-Moyano, Sara; Ferreiro-Monteagudo, Reyes; Veguillas, Pilar; Candia, Antonio; Peña, Raúl; Pinto, Jesús; García-Bermejo, Mª Laura; Muñoz, Alberto; García de Herreros, Antonio; Bonilla, Félix; Carrato, Alfredo; Peña, Cristina (Nature Research, 2018)
    Carcinomas, such as colon cancer, initiate their invasion by rescuing the innate plasticity of both epithelial cells and stromal cells. Although Snail is a transcriptional factor involved in the Epithelial-Mesenchymal ...
  • Erratum to: The UBC-40 urothelial bladder cancer cell line index: a genomic resource for functional studies
    Earl, Julie; Rico, Daniel; Carrillo, Enrique; Rodríguez Santiago, Benjamín; Méndez Pertuz, Marinela; Auer, Herbert; Gómez, Gonzalo; Barton Grossman, Herbert; Pisano, David G.; Schulz, Wolfgang; Pérez Jurado, Luis Alberto; Carrato, Alfredo; Theodorescu, Dan; Chanock, Stephen J.; Valencia, Alfonso; Real, Francisco X. (BioMed Central, 2015)
    Following the publication of our recent article in BMC Genomics [1] a number of aspects were called to our attention. We have carefully reviewed the experiments reported in this manuscript, as well as additional data from ...
  • Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA
    Tajuddin, Salman Muhammad; Amaral, André F.S.; Fernández, Agustín F.; Rodriguez Rodero, Sandra; Rodríguez, Ramón María; Moore, Lee E.; Tardón, Adonina; Carrato, Alfredo; García Closas, Montserrat; Silverman, Debra T.; Jackson, Brian P.; García Closas, Reina; Cook, Ashley L.; Cantor, Kenneth P; Chanock, Stephen J.; Kogevinas, Manolis; Rothman, Nathaniel; Real, Francisco X.; Malats i Riera, Núria (National Institute of Environmental Health Sciences (NIEHS), 2013)
    Background: Altered DNA methylation has been associated with various diseases. Objective: We evaluated the association between levels of methylation in leukocyte DNA at long interspersed nuclear element 1 (LINE-1) and ...
  • Genetic variation in the TP53 pathway and bladder cancer risk: a comprehensive analysis
    Pineda, Silvia; Milne, Roger L.; Calle, M. Luz; Rothman, Nathaniel; López De Maturana, Evangelina; Herranz, Jesús; Kogevinas, Manolis; Chanock, Stephen J.; Tardón, Adonina; Márquez, Mirari; Guey, Lin T.; García Closas, Montserrat; Lloreta Trull, Josep, 1958-; Baum, Erin; González Neira, Anna; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Silverman, Debra T.; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2014)
    Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in other ...
  • Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study
    Moore, Lee E.; Pfeiffer, Ruth M.; Poscablo, Cristina; Real, Francisco X.; Kogevinas, Manolis; Silverman, Debra T.; García Closas, Reina; Chanock, Stephen J.; Tardón, Adonina; Serra, Consol; Carrato, Alfredo; Dosemeci, Mustafa; García Closas, Montserrat; Esteller, Manel; Fraga, Mario F.; Rothman, Nathaniel; Malats i Riera, Núria (Elsevier, 2008)
    BACKGROUND: DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer. METHODS: ...
  • Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker
    Martínez Bosch, Neus; Barranco Priego, Luis Eugenio; Orozco, Carlos Alberto; Moreno, Mireia; Visa Turmo, Laura; Iglesias Coma, Mar; Oldfield, Lucy; Neoptolemos, John P.; Greenhalf, William; Earl, Julie; Carrato, Alfredo; Costello, Eithne; Navarro Medrano, Pilar (Impact Journal, 2018)
    Pancreatic ductal adenocarcinoma (PDA) is the most frequent type of pancreatic cancer and one of the deadliest diseases overall. New biomarkers are urgently needed to allow early diagnosis, one of the only factors that ...
  • Integration Analysis of Three Omics Data Using Penalized Regression Methods: An Application to Bladder Cancer.
    Pineda, Silvia; Real, Francisco X.; Kogevinas, Manolis; Carrato, Alfredo; Chanock, Stephen J.; Malats i Riera, Núria; Van Steen, Kristel (Public Library of Science, 2015)
    Omics data integration is becoming necessary to investigate the genomic mechanisms involved in complex diseases. During the integration process, many challenges arise such as data heterogeneity, the smaller number of ...
  • LINE-1 methylation in granulocyte DNA and trihalomethane exposure is associated with bladder cancer risk
    Salas, Lucas A.; Villanueva Belmonte, Cristina; Tajuddin, Salman Muhammad; Amaral, André F.S.; Fernández, Agustín F.; Moore, Lee E.; Carrato, Alfredo; Tardón, Adonina; Serra, Consol; García Closas, Reina; Basagaña Flores, Xavier; Rothman, Nathaniel; Silverman, Debra T.; Cantor, Kenneth P; Kogevinas, Manolis; Real, Francisco X.; Fraga, Mario F.; Malats i Riera, Núria (Taylor & Francis (Routledge), 2014)
    DNA methylation changes contribute to bladder carcinogenesis. Trihalomethanes (THM), a class of disinfection by-products, are associated with increased urothelial bladder cancer (UBC) risk. THM exposure in animal models ...
  • LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk
    Amaral, André F.S.; Tajuddin, Salman Muhammad; Fernández, Agustín F.; Chanock, Stephen J.; Silverman, Debra T.; Tardón, Adonina; Carrato, Alfredo; García Closas, Montserrat; Jackson, Brian P.; Toraño, Estela; Márquez, Miriam; González Urdinguio, Rocío; García Closas, Reina; Rothman, Nathaniel; Kogevinas, Manolis; Real, Francisco X.; Fernández Fraga, Mario; Malats i Riera, Núria (Cancer Research UK, 2014)
    Background: Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The objectives of this study were to assess the association between LINE-1 methylation ...
  • Mosaic uniparental disomies and aneuploidies as large structural variants of the human genome
    Rodríguez Santiago, Benjamín; Malats i Riera, Núria; Rothman, Nathaniel; Armengol i Dulcet, Lluís; García Closas, Montserrat; Kogevinas, Manolis; Villa, Olaya; Hutchinson, Amy; Earl, Julie; Marenne, Gaëlle; Jacobs, Kevin; Rico, Daniel; Tardón, Adonina; Carrato, Alfredo; Thomas, Gilles; Valencia, Alfonso; Silverman, Debra T.; Real, Francisco X.; Chanock, Stephen J.; Pérez Jurado, Luis Alberto (Elsevier, 2010)
    Mosaicism is defined as the coexistence of cells with different genetic composition within an individual, caused by postzygotic somatic mutation. Although somatic mosaicism for chromosomal abnormalities is a well-established ...
  • Pancreatic cancer risk and levels of trace elements
    Amaral, André F.S.; Porta Serra, Miquel; Silverman, Debra T.; Milne, Roger L.; Kogevinas, Manolis; Rothman, Nathaniel; Cantor, Kenneth P; Jackson, Brian P.; Pumarega Rodríguez, José Antonio; López, Tomàs; Carrato, Alfredo; Guarner, Luisa; Real, Francisco X.; Malats i Riera, Núria (BMJ Publishing Group, 2012)
    Background and Aims: Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously ...
  • Phase Ib study of talimogene laherparepvec in combination with atezolizumab in patients with triple negative breast cancer and colorectal cancer with liver metastases
    Hecht, Joel Randolph; Raman, Steven Satish; Chan, Arlene; Kalinsky, Kevin; Baurain, Jean François; Martín Jiménez, Miguel; Martinez-García, Maria; Berger, Martin D.; Lauer, Ulrich M.; Khattak, Adnan; Carrato, Alfredo; Zhang, Yue; Liu, Kate; Cha, Edward; Keegan, Alissa; Bhatta, Sumita; Strassburg, Christian P.; Roohullah, Aflah (Elsevier, 2023)
    Highlights Safety/efficacy of T-VEC + atezolizumab was explored in patients with triple negative breast cancer or colorectal cancer. Limited evidence of antitumor activity was observed from the combination of atezolizumab ...
  • Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma
    Yu, Jingru; Ploner, Alexander; Kordes, Maximilian; Löhr, J. Matthias; Nilsson, Magnus; López De Maturana, Evangelina; Estudillo, Lidia; Renz, Harald; Carrato, Alfredo; Molero, Xavier; Real, Francisco X.; Malats i Riera, Núria; Ye, Weimin (Wiley, 2021)
    Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late diagnosis at advanced tumor stages. In this study, we aimed to identify plasma protein biomarkers for early detection of PDAC. Totally, 135 ...
  • Polymorphisms in GSTT1, GSTZ1, AND CYP2E1, disinfection by-products, and risk of bladder cancer in Spain
    Cantor, Kenneth P; Villanueva Belmonte, Cristina; Silverman, Debra T.; Figueroa, Jonine D.; Real, Francisco X.; García Closas, Montserrat; Malats i Riera, Núria; Chanock, Stephen J.; Yeager, Meredith; Tardón, Adonina; García Closas, Reina; Serra, Consol; Carrato, Alfredo; Castaño Vinyals, Gemma; Samanic, Claudine; Rothman, Nathaniel; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2010)
    Background: Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water.Objectives: In this study we investigated the combined influence of DBP exposure and polymorphisms in ...
  • Prediction of non-muscle invasive bladder cancer outcomes assessed by innovative multimarker prognostic models.
    López De Maturana, Evangelina; Picornell, Antoni; Masson-Lecomte, Alexandra; Kogevinas, Manolis; Márquez, Mirari; Carrato, Alfredo; Tardón, Adonina; Lloreta Trull, Josep, 1958-; García Closas, Montserrat; Silverman, Debra T.; Rothman, Nathaniel; Chanock, Stephen J.; Real, Francisco X.; Goddard, M. E.; Malats i Riera, Núria; SBC/EPICURO Study Investigators (BioMed Central, 2016)
    BACKGROUND: We adapted Bayesian statistical learning strategies to the prognosis field to investigate if genome-wide common SNP improve the prediction ability of clinico-pathological prognosticators and applied it to ...

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