Browsing by Author "Aznar Benitah, Salvador"

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  • 1)Jarid2 regulates mouse epidermal stem cell activation and differentiation ; 2)Tumor heterogeneity and metastasis-initiation in human squamous cell carcinoma
    Mejetta, Stefania, 1984- (Universitat Pompeu Fabra, 2014-10-31)
    Jarid2 is required for the genomic recruitment of the polycomb repressive complex-2 (PRC2) in embryonic stem cells. However, its specific role during late development and adult tissues remains largely uncharacterized. In ...
  • A complex secretory program orchestrated by the inflammasome controls paracrine senescence
    Acosta, Juan Carlos; Banito, Ana; Wuestefeld, Torsten; Georgilis, Athena; Janich, Peggy, 1981-; Morton, Jennifer P.; Athineos, Dimitris; Kang, Tae-Won; Lasitschka, Felix; Andrulis, Mindaugas; Pascual, Gloria; Morris, Kelly J.; Khan, Sadaf; Jin, Hong; Dharmalingam, Gopuraja; Snijders, Ambrosius P.; Carroll, Thomas; Capper, David; Pritchard, Catrin; Inman, Gareth J.; Longerich, Thomas; Sansom, Owen J.; Aznar Benitah, Salvador; Zender, Lars; Gil, Jesús (Nature Publishing Group, 2013)
    Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence, ...
  • Aged stem cells reprogram their daily rhythmic functions to adapt to stress
    Solanas, Guiomar; Oliveira Peixoto, Francisca; Perdiguero, Eusebio, 1968-; Jardí, Mercè; Ruiz Bonilla, Vanesa, 1979-; Datta, Debayan; Symeonidi, Aikaterini; Castellanos, Andrés; Welz, Patrick-Simon; Martín Caballero, Juan; Sassone-Corsi, Paolo; Muñoz Cánoves, Pura, 1962-; Aznar Benitah, Salvador (Elsevier, 2017)
    Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their ...
  • Collecting mouse livers for transcriptome analysis of daily rhythms
    Mortimer, Thomas; Welz, Patrick-Simon; Aznar Benitah, Salvador; Koronowski, Kevin B. (Elsevier, 2021)
    Molecular daily rhythms can be captured by precisely timed tissue harvests from groups of animals. This protocol will allow the investigator to identify transcriptional rhythms in the mouse liver while also providing a ...
  • Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses
    Toufighi, Kiana, 1980-; Yang, Jae-Seong; Luis, Nuno Miguel, 1982-; Aznar Benitah, Salvador; Lehner, Ben, 1978-; Serrano Pubull, Luis, 1982-; Kiel, Christina (Public Library of Science (PLoS), 2015)
    The molecular details underlying the time-dependent assembly of protein complexes in cellular networks, such as those that occur during differentiation, are largely unexplored. Focusing on the calcium-induced differentiation ...
  • Dnmt3a and dnmt3b associate with enhancers to regulate human epidermal stem cell homeostasis
    Rinaldi, Lorenzo, 1986-; Datta, Debayan; Serrat, Judit; Morey Ramonell, Lluís; Solanas, Guiomar; Avgustinova, Alexandra; Blanco, Enrique; Pons, José Ignacio; Matallanas, David; Kriegsheim, Alex von; Di Croce, Luciano; Aznar Benitah, Salvador (Elsevier, 2016)
    The genome-wide localization and function of endogenous Dnmt3a and Dnmt3b in adult stem cells are unknown. Here, we show that in human epidermal stem cells, the two proteins bind in a histone H3K36me3-dependent manner to ...
  • Dnmt3a and Dnmt3b in Epidermal Homeostasis and Cancer Progression
    Rinaldi, Lorenzo, 1986- (Universitat Pompeu Fabra, 2017-11-20)
    DNA methylation is an essential epigenetic mechanism that regulates gene expression. While DNA methylation dynamics during embryonic formation is fairly well understood, its role in adult tissues is still under investigation. ...
  • Human epidermal stem cell function is regulated by circadian oscillations
    Janich, Peggy, 1981-; Toufighi, Kiana, 1980-; Solanas, Guiomar; Luis, Nuno Miguel, 1982-; Minkwitz, Susann; Serrano Pubull, Luis, 1982-; Lehner, Ben, 1978-; Aznar Benitah, Salvador (Elsevier, 2013)
    Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that in human epidermal stem ...
  • Identity noise and adipogenic traits characterize dermal fibroblast aging
    Aznar Benitah, Salvador; Lafzi, Atefeh; Berenguer-Llergo, Antonio; Youssif, Catrin; Castellanos, Andrés; Solanas, Guiomar; Peixoto, Francisca Oliveira; Stephan-Otto Attolini, Camille; Prats, Neus; Aguilera, Mònica; Martín Caballero, Juan; Heyn, Holger; Aznar Benitah, Salvador (Elsevier, 2018)
    During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage tracing, we ...
  • Loss of dnmt3a and dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-g
    Rinaldi, Lorenzo, 1986-; Avgustinova, Alexandra; Martín, Mercè; Datta, Debayan; Solanas, Guiomar; Prats, Neus; Aznar Benitah, Salvador (eLife, 2017)
    The DNA methyltransferase Dnmt3a suppresses tumorigenesis in models of leukemia and lung cancer. Conversely, deregulation of Dnmt3b is thought to generally promote tumorigenesis. However, the role of Dnmt3a and Dnmt3b in ...
  • RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells
    Morey Ramonell, Lluís; Aloia, Luigi; Cozzuto, Luca; Aznar Benitah, Salvador; Di Croce, Luciano (Elsevier, 2013)
    The Polycomb repressive complex 1 (PRC1) is required for decisions of stem cell fate. In mouse embryonic stem cells (ESCs), two major variations of PRC1 complex, defined by the mutually exclusive presence of Cbx7 or RYBP, ...
  • Targeting lymphoid-derived IL-17 signaling to delay skin aging
    Solá, Paloma; Mereu, Elisabetta; Bonjoch, Júlia; Casado-Peláez, Marta; Prats, Neus; Aguilera, Mònica; Reina García, Óscar, 1976-; Blanco, Enrique; Esteller, Manel; Di Croce, Luciano; Heyn, Holger; Solanas, Guiomar; Aznar Benitah, Salvador (Nature Research, 2023)
    Skin aging is characterized by structural and functional changes that contribute to age-associated frailty. This probably depends on synergy between alterations in the local niche and stem cell-intrinsic changes, underscored ...
  • The central clock suffices to drive the majority of circulatory metabolic rhythms
    Petrus, Paul; Smith, Jacob G.; Koronowski, Kevin B.; Chen, Siwei; Sato, Tomoki; Greco, Carolina M.; Mortimer, Thomas; Welz, Patrick-Simon; Zinna, Valentina M.; Shimaji, Kohei; Cervantes, Marlene; Punzo, Daniela; Baldi, Pierre; Muñoz Cánoves, Pura, 1962-; Sassone-Corsi, Paolo; Aznar Benitah, Salvador (American Association for the Advancement of Science (AAAS), 2022)
    Life on Earth anticipates recurring 24-hour environmental cycles via genetically encoded molecular clocks active in all mammalian organs. Communication between these clocks controls circadian homeostasis. Intertissue ...
  • The role of Cbx4/Polycomb-2 in epidermal stem cell homeostasis.
    Luis, Nuno Miguel (Universitat Pompeu Fabra, 2011-11-07)
    Human epidermis relies on a population of adult stem cells to maintain its homeostasis. Stem cells transit from a dormant to an active state and undergo a tightly regulated process of differentiation that replenishes the ...
  • The role of circadian rhythms in epidermal homeostasis
    Janich, Peggy, 1981- (Universitat Pompeu Fabra, 2012-02-16)
    The natural daily cycles of light and dark have played a fundamental role in shaping the development of an adaptive intrinsic clock mechanism which allows organisms to coordinate the function of multiple organs by settin ...
  • Zrf1 is required to establish and maintain neural progenitor identity
    Aloia, Luigi; Di Stefano, Bruno, 1984-; Sessa, Alessandro; Morey, Lluis; Santanach, Alexandra; Gutierrez, Arantxa; Cozzuto, Luca; Aznar Benitah, Salvador; Graf, T. (Thomas); Broccoli, Vania; Di Croce, Luciano (Cold Spring Harbor Laboratory Press (CSHL Press), 2014)
    The molecular mechanisms underlying specification from embryonic stem cells (ESCs) and maintenance of neural progenitor cells (NPCs) are largely unknown. Recently, we reported that the Zuotin-related factor 1 (Zrf1) is ...