Browsing by Author "Abad Adan, Elena"

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  • Dynamic cross-regulation of antigen-specific effector and regulatory T cell subpopulations and microglia in brain autoimmunity
    Martínez Pasamar, Sara; Abad Adan, Elena; Moreno, Beatriz; Vélez de Mendizábal, Nieves; Martínez Forero, Ivan; García Ojalvo, Jordi; Villoslada, Pablo (BioMed Central, 2013)
    Background: Multiple Sclerosis (MS) is considered a T-cell-mediated autoimmune disease with a prototypical oscillatory behavior, as evidenced by the presence of clinical relapses. Understanding the dynamics of immune cells ...
  • Dynamics and heterogeneity of brain damage in multiple sclerosis
    Kotelnikova, Ekaterina; Kiani, Narsis A.; Abad Adan, Elena; Martínez Lapiscina, Elena H.; Andorrà, Magí; Zubizarreta, Irati; Pulido Valdeolivas, Irene; Pertsovskaya, Inna; Alexopoulos, Leonidas G.; Olsson, Tomas; Martin, Roland; Paul, Friedemann; Tegnér, Jesper; García Ojalvo, Jordi; Villoslada, Pablo (Public Library of Science (PLoS), 2017)
    Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative processes that damage the central nervous system (CNS). However, it is not well understood how these events interact and evolve to evoke ...
  • Impact of zygosity on bimodal phenotype distributions
    Holst Hansen, Thomas; Abad Adan, Elena; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel; Jensen, Mogens; Trusina, Ala; García Ojalvo, Jordi (Elsevier, 2017)
    Allele number, or zygosity, is a clear determinant of gene expression in diploid cells. However, the relationship between the number of copies of a gene and its expression can be hard to anticipate, especially when the ...
  • Transient oscillatory dynamics of interferon beta signaling in macrophages
    Pertsovskaya, Inna; Abad Adan, Elena; Domedel Puig, Núria; García Ojalvo, Jordi; Villoslada, Pablo (BioMed Central, 2013)
    Background: Interferon-beta (IFN-beta) activates the immune response through the type I IFN signaling pathway. IFN-beta is important in the response to pathogen infections and is used as a therapy for Multiple Sclerosis. ...

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