Browsing by Subject "U2 snRNP"

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  • Cracking the code of 3' ss selection in s.cerevisiae
    Meyer, Markus (Universitat Pompeu Fabra, 2010-03-26)
    The informational content of 3' splice sites is low and the mechanisms whereby they are selected are not clear. Here we enunciate a set of rules that govern their selection. For many introns, secondary structures are a key ...
  • Mechanism of regulation of the RPL30 pre-mRNA splicing in yeast
    Macías Ribela, Sara (Universitat Pompeu Fabra, 2008-06-13)
    The mechanisms of pre-mRNA splicing regulation are poorly understood. Here we dissect how the Saccharomyces cerevisiae ribosomal L30 protein blocks splicing of its pre-mRNA upon binding a kink-turn structure including the ...
  • Molecular mechanisms of alternative splicing regulation by antitumor drugs targeting U2 snRNP
    Vigevani, Luisa, 1985- (Universitat Pompeu Fabra, 2016-11-21)
    RNA splicing is the process of removal of introns from pre-mRNAs. It is carried out by the spliceosome, composed of five small nuclear ribonucleoproteins (snRNPs). Several small molecules with antitumor properties target ...
  • Regulation of mammalian 3' splice site recognition
    Corrionero Saiz, Ana (Universitat Pompeu Fabra, 2010-12-16)
    Alternative splicing provides the cell the ability to generate, from a single gene, multiple protein isoforms, sometimes with different or even antagonistic functions. This process is tightly regulated and alterations in ...