T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10 15% of pediatric ALL. The oncogenic transformation of T-cell precursors is driven by a broad spectrum of genetic abnormalities. We have confirmed the high frequency ...

Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the ...