Browsing by Subject "Metàstasi"

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  • Jiao, Wei; Atwal, Gurnit; Polak, Paz; Karlic, Rosa; Cuppen, Edwin; PCAWG Tumor Subtypes and Clinical Translation Working Group; Danyi, Alexandra; Ridder, Jeroen de; van Herpen, Carla; Lolkema, Martijn P.; Steeghs, Neeltje; Getz, Gad; Morris, Quaid; Stein, Lincoln D.; PCAWG Consortium; Stobbe, Miranda D. (Nature Research, 2020)
    In cancer, the primary tumour's organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as ...
  • Vallès Baix, Eric (2015-04-21)
    L’objectiu principal d’aquest treball és realitzar un disseny qualitatiu de fàrmacs derivats de l’indol, inhibidors de la proteïna de membrana VCAM-1. Aquesta és una proteïna que es troba a l’endoteli cerebral, i en una ...
  • Elosua-Bayés, Marc (Universitat Pompeu Fabra, 2023-06-27)
    Understanding multicellular organisms depends on the advent of technologies capable of delivering unprecedented levels of resolution. With new technologies come novel data modalities, which require the development of tools ...
  • Albanell Mestres, Joan; iMolins, A. B.; Martínez, L. C.; López-Muñiiz, J. I. C.; Gil, E. C.; Juan Ferré, A. de; Barco Berrón, Sonia del; Pérez, Y. F.; Mata, J. G.; Palomo, A. G.; Gregori, J. G.; Pardo, P. G.; Mañas, J. J. I.; Hernández, A. L.; Dueñas-Espín, Iván, 1979-; Jáñez, N. M.; Murillo, S. M.; Bofill, Javier Salvador; Auñón, Pilar Zamora; Sánchez-Rovira, Pedro (Springer, 2017)
    Metastatic breast cancer is a heterogeneous disease that presents in varying forms, and a growing number of therapeutic options makes it difficult to determine the best choice in each particular situation. When selecting ...
  • Lambies Barjau, Guillem, 1990- (Universitat Pompeu Fabra, 2019-02-14)
    Cancer cells undergo epithelial-to-mesenchymal transition (EMT) to dissociate from the primary tumor and to survive to chemotherapy. EMT is controlled by Snail1, a transcriptional factor also required for the activation ...
  • Martínez Aranda, Antonio; Hernández, Vanessa; Güney, Emre, 1983-; Muixí, Laia; Foj, Ruben; Baixeras, Núria; Cuadras, Daniel; Moreno, Víctor; Urruticoechea, Ander; Gil, Miguel; Oliva Miguel, Baldomero; Moreno, Ferran; González Suárez, Eva; Vidal, Noemí; Andreu, Xavier; Seguí, Miquel A.; Ballester, Rosa; Castella, Eva; Sierra, Angels (Impact Journals, 2015)
    Brain metastasis is a devastating problem in patients with breast, lung and melanoma tumors. GRP94 and FN14 are predictive biomarkers over-expressed in primary breast carcinomas that metastasized in brain. To further ...
  • Rice, Alistair; Cortes, Ernesto; Lachowski, Dariusz; Oertle, Philipp; Matellan, Carlos; Thorpe, Stephen D.; Ghose, Ritobrata; Wang, Haiyun; Lee, David A.; Plodinec, Marija; del Río Hernández, Armando (MDPI, 2020)
    The invasive properties of cancer cells are intimately linked to their mechanical phenotype, which can be regulated by intracellular biochemical signalling. Cell contractility, induced by mechanotransduction of a stiff ...
  • Martín-Ontiyuelo, Clara; Sánchez Font, Albert; Gimeno Vázquez, Eva; Suárez-Piñera, Marina; Curull Serrano, Víctor (Elsevier, 2020)
  • Celià-Terrassa, Toni; Bastian, Caleb; Liu, Dan; Ell, Brian; Aiello, Nicole M.; Wei, Yong; Zamalloa, Jose; Blanco, Andres M.; Hang, Xiang; Kunisky, Dmitriy; Li, Wenyang; Williams, Elizabeth D.; Rabitz, Herschel; Kang, Yibin (Nature Research, 2018)
    Epithelial-mesenchymal transition (EMT) have been extensively characterized in development and cancer, and its dynamics have been modeled as a non-linear process. However, less is known about how such dynamics may affect ...
  • Pavlovic, Milica (Universitat Pompeu Fabra, 2016-06-16)
    El objetivo de esta tesis era identificar determinantes genéticos de cáncer de mama con metástasis óseas. Para ello se utilizó un enfoque integral que se sustenta en células humanas de cáncer de mama, modelos experimentales ...
  • Rubio Pérez, Carlota; Trincado Alonso, Juan Luis, 1987-; Marchese, Domenica, 1986-; Moutinho, Catia; Ruiz, Sara; Parra Farré, Genís; Heyn, Holger; Seoane, Joan (Nature Research, 2021)
    Brain metastases are the most common tumor of the brain with a dismal prognosis. A fraction of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors (ICI) and the degree and phenotype of ...
  • Domínguez Solà, David (Universitat Pompeu Fabra, 2011-04-12)
    Els factors de transcripció de la família Snail són fonamentals en la "transició epiteli-mesènquima", procés morfogènic essencial en el desenvolupament embrionari i en els fenòmens metastàsics tumorals.<br/>En els mamífers ...
  • Mestre-Farràs, Neus; Guerrero Jijon, Santiago Xavier; Bley, Nadine; Rivero, Ezequiel; Coll, Olga; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Indacochea Cusirramos, Alberto; Casillas-Serra, Carlos; Järvelin, Aino I.; Oliva Miguel, Baldomero; Castello, Alfredo; Hüttelmaier, Stefan; Gebauer, Fátima (Oxford University Press, 2022)
    RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture (RIC) to characterize the melanoma RBPome ...
  • Gibert Fernandez, Joan (Universitat Pompeu Fabra, 2018-12-12)
    Cytoplasmic polyadenylation binding proteins (CPEB) are a family of RNA binding proteins which control the translation of its target mRNAs by modulating the length poly(A) mRNA tail. Cytoplasmic polyadenylation was originally ...
  • Olivera-Salguero, Rubén (Universitat Pompeu Fabra, 2019-07-23)
    Snail1 is the master regulator of the Epithelial-to-Mesenchymal Transition (EMT) and is also crucial for fibroblast activation upon TGFβ signaling. In cancer, Snail1 expression in primary tumors correlates with the appearance ...
  • Solé, Laura; Lobo-Jarne, Teresa; Álvarez-Villanueva, Daniel; Alonso-Marañón, Josune; Guillén, Yolanda; Guix Arnau, Marta, 1974-; Sangrador, Irene; Rozalén, Catalina; Vert, Anna; Lop Gros, Joan; Salido Galeote, Marta; Bellosillo Paricio, Beatriz; García-Romero, Raquel; Garrido, Marta; González, Jessica; López Arribillaga, Erika, 1986-; Iglesias Coma, Mar; Celià-Terrassa, Toni; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Research, 2022)
    Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that remain ineffective in a proportion of patients. Whether and how non-curative DNA damage-based treatment affects tumor cell behavior and ...
  • Pardo Pastor, Carlos (Universitat Pompeu Fabra, 2018-12-11)
    The mechanical dependence of transformation and metastasis is an emerging field, but the role of mechanosensitive channels has been largely omitted. This thesis focuses on the roles played by the mechanosensitive ion ...
  • Ribera, Jordi; Portolés, Irene; Córdova-Jover, Bernat; Rodríguez-Vita, Juan; Casals, Gregori; Gónzalez-de la Presa, Bernardino; Graupera, Mariona; Solsona-Vilarrasa, Estel; Garcia-Ruiz, Carmen; Fernández-Checa, José C.; Soria Rodríguez, Guadalupe; Tudela, Raúl; Esteve-Codina, Anna; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Jiménez, Wladimiro; Sessa, William C.; Morales-Ruiz, Manuel (Nature Research, 2021)
    DHX15 is a downstream substrate for Akt1, which is involved in key cellular processes affecting vascular biology. Here, we explored the vascular regulatory function of DHX15. Homozygous DHX15 gene deficiency was lethal in ...
  • Ní Chárthaigh, Róisín-Ana (Universitat Pompeu Fabra, 2020-09-15)
    RNA-binding proteins are potent regulators of post-transcriptional gene expression. Among the repertoire of RNAs bound by a particular RNA-binding protein, networks of co-ordinately regulated RNAs, or ‘regulons’, are ...
  • Wurth, Laurence; Papasaikas, Panagiotis; Olmeda, David; Bley, Nadine; Calvo, Guadalupe T.; Guerrero Jijon, Santiago Xavier; Cerezo-Wallis, Daniela; Martínez-Useros, Javier; García-Fernández, María; Hüttelmaier, Stefan; Soengas, María S.; Gebauer, Fátima (Elsevier, 2016)
    RNA binding proteins (RBPs) modulate cancer progression through poorly understood mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma tumors and promotes invasion and metastasis. iCLIP sequencing, ...

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